Effects of Multi-Strain Probiotics and Early Life Multi-Mineralization on Iron-Zinc Homeostasis in Neonatal Piglets

The present study was conducted to investigate the effect of multi-strain probiotics and multi-minerals on iron-zinc homeostasis in neonatal piglets. Eight apparently healthy sows were selected and randomly divided into four equal groups. Piglets from two sows of each group were taken for study [Control (total piglets-17), multi-minerals (total piglets-22), multi-strain probiotics (total piglets-15) and multi-minerals + multi-strain probiotics (total piglets-23)]. The Blood samples were collected from anterior vena cava of piglets on day 0, 7, 14 and 21 post-farrowing. The zinc and iron concentration were measured using spectrophotometer. The results revealed that the mean zinc and iron concentrations were markedly higher in multi-minerals group as compare to control, multi-strain probiotics and multi-minerals + multi-strain probiotics groups on day 0. Moreover, that in MM group, Zn concentration on day 14 and 21 and iron values on day 21 were significantly lower as compared to day 0. The mean concentration of iron on day 7 and zinc on day 7 and 21 were significantly higher as compared to day 0 in multi-strain probiotics group. In multi-minerals + multi-strain probiotics group, mean concentration of iron on day 14 and 21 and zinc value on day 14 were significantly lower as compared to day 0 and day 7. It is concluded that the supplementation of multi-strain probiotics has better effect on iron zinc homeostasis as compare to multi-minerals and multi-minerals + multi-strain probiotics supplementations

Semantically Rich, Context Aware Access Control for Openstack

IEEE International Conference on Collaboration and Internet Computing 2018In an open source cloud computing platform such as OpenStack, operators use Role-Based Access Control (RBAC) model to grant access to cloud resources. However, these user-level role-based access control techniques fail to include comprehensive user context. We believe a situational aware framework will improve security by bringing in user's context to such cloud systems. In this paper, we create a semantically rich context-sensitive access control system for OpenStack by incorporating the user's current context attributes like location, time, etc. In a proof-of-concept implementation, we integrate a knowledge graph with our own access control system to express and enforce the contextual-situation policies in OpenStack. The proposed system provides enhanced, flexible access control while minimizing the overhead of altering the existing access control framework. We also discuss various use cases, to highlight the benefits of our system and show enforcement results.https://ieeexplore.ieee.org/document/853786

Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats

The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P&lt;0.001, P&lt;0.01 and P&lt;0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P&lt;0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P&lt;0.001).</jats:p

Plasma trough imatinib levels and molecular response in patients of chronic myeloid leukemia (CML): A single institution study from India.

7079 Background: One of the reasons proposed for suboptimal responses in Chronic Myeloid Leukemia (CML) patients receiving standard-dose Imatinib has been low blood levels of the drug. Our study aimed to determine the correlation between mean trough Imatinib plasma levels and molecular response in CML chronic phase patients at our centre. We also attempted to compare imatinib plasma levels in patients receiving Gleevec (Novartis) versus patients who were on the generic version of the drug. Methods: One hundred and thirty one (131) CML Chronic phase patients were included in this study. All patients had received 400 mg of imatinib for more than 2 year. Plasma Imatinib trough levels were estimated by high-performance liquid chromatography (HPLC). In order to estimate a threshold for plasma imatinib level that correlates with a favorable response, a receiver operating characteristic (ROC) curve was constructed. Patients were divided into two groups: those with Major Molecular Response (MMR) [bcr/abl : abl ratio &lt;1% as assessed by RQ-PCR] or better (Responders) and those without MMR (bcr/abl : abl ratio =/&gt; 1% as assessed by RQ-PCR) [Non Responders]. Imatinib plasma levels were also compared in patients who were on Gleevec versus those who were on the generic version of the drug. Results: The mean trough imatinib plasma level in the responders was significantly higher (2.10±1.18µg/ml) than in the non responders (1.31±0.72µg/ml) with p value of 0.001. The area under ROC curve was 0.733, with best sensitivity (51.85%) and specificity (89.42%) at a plasma threshold of 0.988 µg/ml. There was no significant difference between the mean trough plasma imatinib levels of the patients who were on Gleevec as compared to those who were on generic Imatinib (p value &gt; 0.05). Conclusions: Plasma Imatinib trough levels were statistically similar in the Gleevec and generic Imatinib groups. These levels showed a statistically significant correlation with molecular response. Trough plasma imatinib levels may be a marker for suboptimal response to Imatinib and may identify patients in whom increase of drug dose or change to second generation tyrosine kinase inhibitors may be indicated. </jats:p

A Critical review on Pharmacodynamics of Basti Chikitsa and its action on Enteric Nervous System

Ayurveda being an ancient science it has developed through many experiences and experiment in medicines. Panchakarma therapy is a very imperative and essential part of Ayurvedic treatment. Panchakarma (Vaman,Virechan, Nasya, Anuvasan &amp; niruha) practices to get complete cure of disease, Basti is the main treatment as it possesses a wide spectrum of effects and is thought to be the Ardhachikitsa (50% of all treatment modality) in Ayurveda. Though Basti is given in the Pakvashaya (Rectum and Colon) its active ingredients i.e. “Virya of the Basti” spreads in the entire body to get desire action. BastiVirya may act through enteric nervous system (ENS). The gastrointestinal system has a network of nerve fibres, which is known as ‘Enteric Nervous System (ENS). Similar to brain, ENS sends and receives impulses; record experiences and responds to various stimuli. </jats:p

Review on Digital Image Processing Using Image Retrieval and Recognition

Image processing is one of the vast growing scenarios. From various resources this method is used to improve raw images received from satellites, space probes, aircrafts, military reconnaissance flights or pictures taken in normal day-to-day life from normal cameras. It is a kind of signal processing. This paper is an overview of image processing methods.</jats:p