A comparative study of stool antigen Immunocard STAT HpSA test with biopsy in diagnosis of H Pylori Infection

The present study was conducted on 78 cases in the Department of Medicine at G.S.V.M Medical College, Kanpur who reported with various gastrointestinal symptoms such as dyspepsia, heartburns, nausea, vomiting and loss of appetite. They all were advised for biopsy by the physician. Patients treated with antibiotics, bismuth or proton pump inhibitors within 4 weeks preceding the study were excluded. Invasive tests using mucosal biopsies including histology and rapid urease test (RUT) were used to establish the gold standard in order to evaluate the accuracy of Immunocard STAT HpSA. Sensitivity, Specificity, Positive Predictive Value and Negative Predictive Value of Immunocard STAT HpSA as compared to gold standard were 95.5%, 81.8%, 96.9% and 75.0% respectively. It is thus concluded that the Immunocard STAT HpSA test has a diagnostic value comparable to the gold standard in detecting H Pylori. The sensitivity and specificity of the test is fair enough to be used as a test for screening purpose and also for diagnosis and treatment of H.Pylori infection in clinical practic

Comparison of clinical and CSF profiles in 62 Adults with tuberculous and pyogenic meningitis

Background: Many a times differentiating tuberculous meningitis from pyogenic meningitis becomes very difficult. The diagnosis depends upon clinical manifestation and cytochemical analysis of cerebrospinal fluid (CSF). Many researchers found that the CSF glucose: protein ratio less than 0.5 and Adenosine deaminase levels (ADA) in cerebrospinal fluid are useful to differentiate tubercular disease from non-tubercular meningitis.Methods: Sixty-two patients admitted to our tertiary hospital with symptoms and signs of meningitis were selected and divided into two groups: tubercular (n=39) and pyogenic (n= 23), depending upon the accepted criteria. Clinical features and CSF parameters noted in each patient. Cut off value of ADA kept at or above 10 IU/L for tubercular meningitis.Results: The mean age of patients with tubercular meningitis was 39.07±16.67 years and that of pyogenic meningitis 34.35±16.73 years. Clinically fever was present in 60 (96.77%), headache in 49 (79.03%), and vomiting in 44 (70.96%) patients. Meningeal signs – neck rigidity in 46 (74.2%), Kernig’s sign in 37 (59.68%) and Brudzinski’s sign in 18 (29.03%) patients. On CSF cytological and biochemical analysis the mean total white blood cell count was 256.74±184.03 /cmm, mean protein 182.22±113.12 mg/dl and mean sugar 52.85±19.3mg/dl in TBM whereas in pyogenic meningitis 106.17±185.18 / cmm, 88.78±114.35 mg/ dl, and 63.47±19.48 mg/dl respectively. Out of 39 tuberculous patients, 33 patients were found to be having CSF ADA at or above the cutoff value of 10 IU/L while only one among pyogenic meningitis. On comparison between two groups, the CSF ADA level found to be statistically highly significant (P < 0.001) with overall accuracy of the test was 85.5 %.Conclusions: We found that the duration of illness, estimation of cerebrospinal fluid ADA with a cut off value of 10 IU/L and CSF glucose: protein ratio of 0.5 may useful in differentiating tuberculous from pyogenic meningitis. posterior cranial fossa surgeries. This work will also be useful to anthropologists, forensic science experts for determination of sex of the skull along with other parameters

Comparing the efficacy of movement with mobilization in respect to graded mobilization in adhesive capsulitis of shoulder

Adhesive Capsulitis is a clinical syndrome with painful restriction of both active and passive movements. The conSSdition is aggravated by systemic problems like diabetes mellitus, cardiovascular disease and reflex sympathetic dystrophy. Prolonged activity causes small scapular and biceps muscles to waste faster, load on joint increases and degenerative changes sets in. capsule is fibrosed and shoulder movements are decreased. If the movements are continued, then the fibrosis gradually breaks, movement returns but never come back to normal. Thus, we hypothesize that there will be no significant difference between movement with mobilization and graded mobilization on functional performance in adhesive capsulitis. Total 60 subjects were taken for this study as per inclusion & exclusion criteria. Each group consists of 30 subjects. Treatment in both the groups was given for 15 days continuously. Group A received Movement with mobilization technique whereas Group B received graded mobilizations. The outcome measures used were VAS scale for measuring pain, ROM of the shoulder joint movements using goniometer, power of the muscle assessed through MMT, quality of sleep assessed through Pittsburgh sleep quality Index and  Shoulder pain and disability index (SPADI).

Comparing the Efficacy of Movement with Mobilization in Respect to Graded Mobilization in Adhesive Capsulitis of Shoulder

Adhesive Capsulitis is a clinical syndrome with painful restriction of both active and passive movements. The conSSdition is aggravated by systemic problems like diabetes mellitus, cardiovascular disease and reflex sympathetic dystrophy. Prolonged activity causes small scapular and biceps muscles to waste Faster, load on joint increases and degenerative changes sets in. capsule is fibrosed and shoulder movements are decreased. If the movements are continued, then the fibrosis gradually breaks, movement returns but never come back to normal. Thus, we hypothesize that there will be no significant difference between movement with mobilization and graded mobilization on functional performance in adhesive capsulitis. Total 60 subjects were taken for this study as per inclusion & exclusion criteria. Each group consists of 30 subjects. Treatment in both the groups was given for 15 days continuously. Group A received Movement with mobilization technique whereas Group B received graded mobilizations. The outcome measures used were VAS scale for measuring pain, ROM of the shoulder joint movements using goniometer, power of the muscle assessed through MMT, quality of sleep assessed through Pittsburgh sleep quality Index and  Shoulder pain and disability index (SPADI).