255 research outputs found
Hyperinsulinaemic hypoglycaemia - a diagnostic challenge. A report of two atypical cases
Objectives: The authors describe 2 atypical cases of patients with hypoglycaemia, suspected for insulinoma.
Methods: The 2 reports are accompanied by a concise review of the literature.
Results: Patient 1 had a distal pancreatectomy performed for suspected insulinoma, and was diagnosed with a glucagonoma and beta-cell hyperplasia (nesidioblastosis). To the authorsâs knowledge, co-existing glucagonoma and nesidioblastosis had not been previously reported.
Patient 2 was diagnosed with a benign insulinoma and 5 years later with metastatic disease.
Conclusion: The authors conclude that insulinomas are rare entities which often present a diagnostic and therapeutic challenge. In such cases, patient referral to tertiary multidisciplinary centers is recommended
Characterization of an E2-Substituted Cstrain Vaccine Candidate with Potential Diva Vaccine Properties
Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo
Challenges in Interpretation of Thyroid Function Tests in Pregnant Women with Autoimmune Thyroid Disease
Physiological changes during gestation are important to be aware of in measurement and interpretation of thyroid function tests in women with autoimmune thyroid diseases. Thyroid autoimmune activity is decreasing in pregnancy. Measurement of serum TSH is the first-line screening variable for thyroid dysfunction also in pregnancy. However, using serum TSH for control of treatment of maternal thyroid autoimmunity infers a risk for compromised foetal development. Peripheral thyroid hormone values are highly different among laboratories, and there is a need for laboratory-specific gestational age-related reference ranges. Equally important, the intraindividual variability of the thyroid hormone measurements is much narrower than the interindividual variation (reflecting the reference interval). The best laboratory assessment of thyroid function is a free thyroid hormone estimate combined with TSH. Measurement of antithyroperoxidase and/or TSH receptor antibodies adds to the differential diagnosis of autoimmune and nonautoimmune thyroid diseases
Virulence in pigs of vPader10 rescued from an infectious cDNA clone of the CSFV strain Paderborn
A Comparative Study of CSFV Antibody Levels in Pigs Vaccinated with the Chimeric Vaccine CP7_E2GIF or a C-Strain Vaccine
Genomic epidemiology of a major Mycobacterium tuberculosis outbreak: Retrospective cohort study in a low incidence setting using sparse time-series sampling
Experimental infection of pregnant sows with African swine fever (ASFV Georgia 2007): Clinical outcome, pathogenesis and vertical transmission
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