Grading the Performance of a Legislator

The case is made that Rep Robert Kastenmeier should be honored as a distinguished public servant. His record reflects both a concern for the public interest and a sensitivity to the needs of special interest groups

On the etale cohomology of algebraic varieties with totally degenerate reduction over p-adic fields

Let K be a finite extension of Q_p and X a smooth projective variety over K. We define the notion of totally degenerate reduction of such an X and the associated Chow complexes of the special fibre of a suitable regular proper model of X over the ring of integers of K. If X has such reduction, we then show that for all l, the Q_l-adic etale cohomology of X has a filtration whose graded quotients are isomorphic, as Galois modules, to the tensor product of a finite dimensional Q-vector space (with a finite unramified action of Galois) with twists of Q_l by the cyclotomic character.Comment: 29 pages This and math.AG/0601401 replace math.AG/030612

Weights in arithmetic geometry

The concept of weights on the cohomology of algebraic varieties was initiated by fundamental ideas and work of A. Grothendieck and P. Deligne. It is deeply connected with the concept of motives and appeared first on the singular cohomology as the weights of (possibly mixed) Hodge structures and on the etale cohomology as the weights of eigenvalues of Frobenius. But weights also appear on algebraic fundamental groups and in p-adic Hodge theory, where they become only visible after applying the comparison functors of Fontaine. After rehearsing various versions of weights, we explain some more recent applications of weights, e.g., to Hasse principles and the computation of motivic cohomology, and discuss some open questions.Comment: 27 page

Genomic Organization, Splice Variants and Expression of CGMl, a CD66-related Member of the Carcinoembryonic Antigen Gene Family

The tumor marker carcinoembryonic antigen (CEA) belongs to a family of proteins which are composed of one immunogiobulin variable domain and a varying number of immunoglobulin constant-like domains. Most of the membrane-bound members, which are anchored either by a glycosylphosphatidylinositol moiety or a transmembrane domain, have been shown to convey cell adhesion in vitro. Here we describe two splice variants of CGMI. a transmembrane member of the CEA family without immunoglobulin constant.like domains. CGM1a and CGM1c contain cytopiasmic domains of 71 and 31 amino acids, respectively, The cytoplasmic region of CGM1a is encoded by four exons (Cyt1-Cyt4). Differential splicing of the Cyt1 exon (53 bp)..

Donepezil and related cholinesterase inhibitors as mood and behavioral controlling agents.

Acetylcholinesterase inhibitors (ChEIs) enhance neuronal transmission by increasing the availability of acetylcholine in muscarinic and nicotinic receptors. This effect is believed to be responsible for the beneficial and protective effects of ChEIs on cognition in patients with Alzheimer's disease (AD). Effects of ChEIs on mood and behavior have also been reported. Earlier observations were limited by the exclusive availability of intravenous forms of administration, the short half-life of the formulations, and the high frequency of peripheral side effects. The introduction, in recent years, of better tolerated and less invasive compounds has rekindled the interest in cholinergic central nervous system mechanisms and has given rise to studies in areas other than cognition. The ChEI donepezil has been involved in the largest number of studies and positive reports. Preliminary observations suggest the possible value of ChEIs in the management of behavioral dysregulation, apathy, irritability, psychosis, depression, mania, tics, and delirium and in the diagnosis of depression, panic, and personality disorders