Green synthesis and anxiolytic activity of some new dibenz-[1,4] diazepine-1-one analogues

AbstractA facile, green approach for the synthesis of some new dibenz[1,4]-diazepine-1-one by a three component reaction of Diamine, 1,3 diketone and aromatic aldehyde using oxalic acid as catalyst in water is described. The products are formed in good yields (92–94%). Newly synthesized dibenz [1,4]-diazepine-1-one analogues were evaluated for the anxiolytic activity by the elevated plus maze method. From the activity data it is observed that compounds, 4g, 4h and 4k show promising anxiolytic activity

Water mediated oxalic acid catalyzed one pot synthesis of 1,8-dioxodecahydroacridines

A simple and convenient one step method for synthesis of acridines and its derivatives from condensation of aromatic aldehydes, cyclic diketones, aryl amines or ammonium acetates using water as a reaction medium is reported. The present protocol provides several advantages such as good yields, cheap catalyst, short reaction time, easy work-up, simplicity in operation. The use of environmentally benign water as a solvent supports the green aspect of method