Middle Cerebral Artery Aneurysm Coiling without Assisted Techniques – A Good Alternative, Single Venture Experience

Objective:  To evaluate the result of a coiling of middle cerebral artery aneurysms without auxiliary techniques. Material and Methods:  This study was conducted from June 2010 to September 2019 in the Department of Neuroradiology, Punjab Institute of Neurosciences, Lahore. There were a total of 500 patients with unilateral and bilateral cerebral aneurysms at the MCA level that have been included in this study which comprise of both sexes. Results:  There was a total of 500 patients, which comprised of 200 (40%) men and 300 (60%) women. Their ages ranged from 22 to 65 years. The majority number of patients was in their fifth 180 (30%) and sixth decade 150 (30%) of life. In our study, a successful coiling was performed in 490 (98%) patients with minimal re-canalization of MCA aneurysms. In 10 (2%) procedure was unsuccessful due to vasospasm. Conclusion:  The conventional coiling in middle cerebral artery aneurysms can be effective and safe without auxiliary techniques

N-Cyclo­hexyl-N′-(4-nitro­benzo­yl)thio­urea

In the title compound, C14H17N3O3S, the nitro group is twisted slightly by 2.6 (3)° from the benzene ring plane and the thio­ureido group makes a dihedral angle of 52.06 (4)° with the benzene ring. The cyclo­hexyl ring displays a chair conformation. An intra­molecular N—H⋯O inter­action is present. In the crystal, inter­molecular N—H⋯S hydrogen bonds link the mol­ecules into centrosymmetric dimers. π–π inter­actions between inversion-related benzene rings (centroid–centroid distance = 4.044 Å) and C—H⋯π inter­actions (H⋯centroid distance = 3.116 Å) between one methyl­ene cyclo­hexyl H atom and the benzene ring are also present

Synthesis and X-ray crystallography of N,N'-di(2-hydroxybenzylidene)hydrazine

The biologically active N,N'-di(2-hydroxybenzylidene)hydrazine has been synthesized and specifically characterized by X-ray crystallography. There are two molecules of N,N'-di(2-hydroxybenzylidene)hydrazine, C14H12N2O2, in the unit cell. The N,N'-di(2-hydroxy benzylidene)hydrazine molecule is planar, with maximum deviation from the mean plane being less than 0.028(2) Å. Intramolecular O-H···N hydrogen bonding interactions were observed in the crystal lattice which connected the molecules into chain running along b-axis

Acute ischemic stroke treatment barriers in Pakistan

Worldwide stroke is the second most common cause of death and the third most common cause of disability (1). No large-scale epidemiological studies are available to determine the true incidence of stroke in Pakistan. There is only one published stroke prevalence study which was conducted in a community residing in Karachi, the prevalence was 4.8%, however the results of the study should be interpreted with caution as a non-validated questionnaire was used. (2). Another community-based survey suggested as estimated 21.8% prevalence of stroke in an urban slum of Karachi (3). These studies although published in local journals but do not highlight the aspects of stroke treatment and prevalence. While the incidence is decreasing in high-income countries, it is increasing in low-income countries such as Pakistan, where there is not even a single established comprehensive stroke center with fully equipped facilities to do endovascular treatment of AIS. Medical advances in stroke treatment have greatly improved survival rates and disability from stroke during the last decade, these advances include cerebral angiographic techniques to remove the blood clot from brain vessels called Mechanical Thrombectomy. The quality of care and equipment available to stroke victims makes a world of difference. That is why the public needs to have access to the stroke center. Neurointerventional Radiology training and practice in Pakistan is still in early phases, being practiced in few leading hospitals of the country but no separate accredited postgraduate training program still available

Synthesis, characterization and antibacterial activity of nickel (II) and copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide

Nickel and copper metal complexes of N-(R-carbamothioyl)-4-nitrobenzamide (R = diphenyl and ethylbutyl) were synthesized and characterized by IR, 1H NMR, mass spectrometry and elemental analysis. The spectroscopic data are consistent with the ligand and the metal complexes containing two O and S chelated ligands. N-(diphenylcarbamothioyl)-4-nitrobenzamide, HL1, was characterized by a single crystal X-ray diffraction study. It crystallizes in the triclinic space group P  with unit cell dimensions of a = 6.8044(4) Å, b = 10.0113(6) Å, c = 13.2365(8) Å, α = 6.8044(4) °, β = 78.171(4) °, γ = 13.2365(8)°, V = 882.43(9) Å3. The ligands coordinate as bidentates yielding essentially neutral complexes of the type [ML2]. The ligands and complexes were screened for their in vitro antibacterial activities and comparatively the complexes showed greater antibacterial efficacy than the thiourea derivative ligands

Nanostructured thin film of iron tin oxide by aerosol assisted chemical vapour deposition using a new ferrocene containing heterobimetallic complex as single-source precursor

Aerosol assisted chemical vapour deposition (CVD) is a sophisticated, unique and modern technique which is used to deposit coatings, films, and other related structures from thermally unstable or the involatile precursors at laboratory and large scale productions. A light weight semiconducting and ceramic oxide based coatings on appropriate substrates can be produced at a lower cost by employing chemical vapour deposition method. There is broader choice of chemical precursors and their availability for obtaining high quality thin films at lower cost and the reaction environment is more flexible ranging from low pressure to atmospheric pressure in CVD. New ferrocene containingheterobimetallic precursor, [C58H80Fe2O4Sn2] has been synthesized and characterized by elemental analysis, FT-IR spectroscopy, thermogravimetric analysis and molecular structure was determined by X-ray single crystal analysis. The heterobimetallic complex was used as a single-source precursor for the growth of iron tin oxide thin film by aerosol assisted chemical vapor deposition. The deposited thin film was characterized by X-ray diffractometer, scanning electron microscopy and atomic force microscopy techniques. The average roughness of deposited film at 425 °C from heterobimetallic precursor was in the range of 4.39 nm. The deposited thin film on glass strip was found to have no cracks, excellent adhesion and to be crystalline in nature and free from any carboneous impurities

1-(4-Bromo­phen­yl)-3-(2-thienylcarbon­yl)thio­urea

The title compound, C12H9BrN2OS2, consists of two planar parts, viz. the thio­phene ring including all substituents (r.m.s. deviation 0.007 Å) and the benzene ring including the respective substituents as well as the thione group (r.m.s. deviation 0.05 Å). The inter­planar angle is 18.84 (6)°. An intra­molecular Cphen­yl—N—H⋯OC hydrogen bond is observed. The three-dimensional packing involves three types of inter­actions, viz. N—H⋯S, C—H⋯S (× 2) and Br⋯S [3.6924 (6) Å]

N,N′-(Methyl­enedi-p-phenyl­ene)dibenzamide

The title compound, C27H22N2O2, consists of two chemically equivalent halves. However, it displays no crystallographic symmetry, only an approximate local twofold symmetry (r.m.s. deviation = 0.15 Å between the two halves of the molecule) is observed. In the crystal, mol­ecules are connected by two anti­parallel classical N—H⋯O hydrogen bonds, forming broad chains parallel to (10). A series of weak C—H⋯N/O hydrogen bonds is also present