Traumatic wound dehiscence after corneal keratoplasty

ABSTRACTPurpose:To assess patient characteristics, risk factors, outcomes, and the treatment of wound dehiscence (WD) in patients after corneal keratoplasty.Methods:Retrospective chart review of 11 eyes of 11 patients with corneal grafts who underwent repair of WD from January 1, 2004 to December 31, 2012 at Hospital Oftalmologico de Brasilia.Results:Eight (72.7%) patients were men and three were women. Six (54.5%) patients had deep anterior lamellar keratoplasty (DALK) and 5 had penetrating keratoplasty. The mean age at trauma was 31.1 years. The mean time from corneal keratoplasty to WD was 12.82 months (range, 3-33 months). The mean best-corrected visual acuity of patients before trauma was 20/60 (0.48 logMAR) and after final treatment was 20/160 (0.90 logMAR) (P=0.15). In one case, visual acuity decreased to no light perception because of retinal detachment and phthisis bulbi. Accidental blunt trauma and fall were the most common causes of WD.Conclusion:Patients who undergo corneal keratoplasty have a life-long risk of WD. The full-thickness rupture at the graft-host junction in our study suggests that the junction remains vulnerable, even following DALK, and can rupture with trauma. In our series, depending upon the severity of the trauma, postkeratoplastic WD can be associated with a good visual prognosis

Atlas’ Promotion

https://thekeep.eiu.edu/lib_exhibits_space2019_art/1010/thumbnail.jp

Improvement of the quality in a pharmaceutical company on the basis of the Improvement Model and in RDC 210/03

Orientador: Ademir PetenateDissertação (mestrado profissional) - Universidade Estadual de Campinas, Faculdade de Engenharia MecanicaResumo: O objetivo deste estudo foi aplicar a utilização o ¿Modelo de Melhoria¿, à gestão de controle em processo, visando a obtenção de qualidade no produto terminado e, posteriormente, implantá-lo em outras linhas de produção. O trabalho foi realizado no setor de revisão de produto final de uma indústria farmacêutica, na atividade de controle em processo. Utilizou-se o Modelo de Melhoria na determinação dos pontos críticos a serem trabalhados e as Normas de Amostragem por Atributos da ABNT para a determinação dos planos de amostragem. O estudo envolveu a avaliação de unidades do produto que já haviam passado pela revisão final e a determinação de itens com defeitos que não tinham sido separados pelo processo de revisão 100% caracterizando, assim, como falha de revisão. A reestruturação do Controle em Processo e o treinamento contínuo dos envolvidos propiciaram a diminuição do número de falhas ao longo do tempo, obtendo-se, com isto, melhoria de qualidade do produto terminadoAbstract: The objective of this study was to show that the use of the ¿Improvement Guide¿ methodology to obtain quality in products. The Improvement Guide Methodology was employed to determine the critical factors to be addressed and the ¿Sampling Rules¿ by attributes in acordance to ABNT (Brazilian Association of Technical Rules) was employed to determine the sampling plans. The study comprised the evaluation of samples that had already gone through the final revision process, thus bringing out defective items that had not been detected by the process, therefore being classified as 100% revision failure. By restructuring the process control and by creating an awareness of the employees envolved in the process, failures decreased through time and the problems were corrected, therefore leading toan improvement in the quality of the productsMestradoGestão da Qualidade TotalMestre Profissional em Engenharia Mecanic

Larval development of Aelurostrongylus abstrusus in experimentally infected Rumina decollata snails

Aelurostrongylus abstrusus is a lungworm distributed worldwide that affects wild and domestic cats, causing bronchopneumonia of varying intensity. Snails serve as intermediate hosts. The aim of the present study was to assess the larval development of A. abstrusus in R. decollata snails and to investigate its potential as an intermediate host. For this purpose, first-stage larvae (L1) of A. abstrusus were obtained from the faeces of naturally infected cats. Doses of 500 L1/snail were given to 24 R. decollata snails, placed on the soil of the breeder chamber, and maintained under laboratory conditions. Three snails were killed at 8, 10, 12, 16, 22, 26, 45 and 55 days post-infection (dpi), and the muscular foot and visceral body were separately digested by an artificial digestion technique. The morphometric parameters of different larval stages were recorded. The mean number of larvae reaching the infective stage at the end of the study (L3) was 262 larvae/snail. The greatest development to L3 was recorded from days16 to 55 pi, during which the isolation was maximum. A. Abstrusus L3 were isolated from the viscera, but isolation from the snail foot was significantly higher. Our results showed for the first time the ability of A. Abstrusus larvae to develop in R. decollata, thus serving as a potential intermediate host