Peran Orang Tua Dalam Meminimalkan Risiko Bullying Pada Anak-Anak

Adolescence marks a crucial transition from childhood to adulthood, encompassing emotional, social, physical, and psychological growth. However, this period often presents adolescents with psychological hurdles as they navigate self-identity and explore their surroundings. Among these challenges, bullying emerges as a significant concern, globally pervasive, particularly within school environments. Bullying exerts detrimental effects on its victims, precipitating severe psychological disorders such as anxiety, fear, and depression. Thus, the pivotal role of parents in aiding children through this ordeal cannot be overstated. Parents play a crucial role in offering emotional support, recognizing signs of bullying, and fostering effective coping mechanisms. They can cultivate a safe and nurturing atmosphere at home, encouraging engaging activities and participation in supportive communities. Through proper guidance and support, children can bolster their self-assurance and enhance their mental well-being, effectively confronting the adversities of bullying

SOLID DOSAGE FORM DEVELOPMENT OF GLIBENCLAMIDE WITH INCREASING THE SOLUBILITY AND DISSOLUTION RATE USING COCRYSTALLIZATION

Objective: The aim of this study was to develop a solid dosage form of glibenclamide with increasing the solubility properties of glibenclamide with cocrystallization method.Methods: Virtual screening was performed to investigate the interaction between glibenclamide and a co-former. Saccharin, the selected co-former, then co-crystallized with glibenclamide with equimolar ratios of 1:1 and 1:2 using the solvent evaporation method. Further characterization was performed using an infra-red (IR) spectrophotometer, differential scanning calorimetry (DSC), and powder x-ray diffraction (PXRD).Results: Co-crystals of 1:2 equimolar ratio were more highly soluble compared to pure glibenclamide (30-fold for 12 h and 24-fold for 24 h). The dissolution rate had also increased from 46.838% of pure glibenclamide to 77.655% of glibenclamide co-crystal in 60 min. There was no chemical reaction observed during the co-crystallization process based on the IR spectrum. However, there was a new peak in the X-Ray diffractogram and a reduction of melting point in the DSC curve, indicating the formation of co-crystals.Conclusion: The optimal co-crystal ratio of glibenclamide-saccharin was found to be 1:2, which was successful in improving the solubility of glibenclamide