Formulation and evaluation of ileo-colonic targeted matrix-mini-tablets of Naproxen for chronotherapeutic treatment of rheumatoid arthritis

AbstractIn this present research work, the aim was to develop ileo-colonic targeted matrix-mini-tablets-filled capsule system of Naproxen for chronotherapeutic treatment of Rheumatoid Arthritis. So Matrix-mini-tablets of Naproxen were prepared using microsomal enzyme dependent and pH-sensitive polymers by direct compression method which were further filled into an empty HPMC capsule. The compatibility was assessed using FT-IR and DSC studies for pure drug, polymers and their physical mixtures. The prepared batches were subjected to physicochemical studies, drug content estimation, in-vitro drug release and stability studies. When FTIR and DSC studies were performed, it was found that there was no interaction between Naproxen and polymers used. The physicochemical properties of all the prepared matrix-mini-tablets batches were found to be in limits. The drug content percentage in the optimized formulation F18 was found to be 99.24±0.10%. Our optimized matrix-mini-tablets-filled-capsule formulation F18 releases Naproxen after a lag time of 2.45±0.97h and 27.30±0.86%, 92.59±0.47%, 99.38±0.69% at the end of 5, 8, 12h respectively. This formulation was also found to be stable as per the guidelines of International Conference on Harmonisation of Technical Requirements of Pharmaceuticals for Human Use. Thus, a novel ileo-colonic targeted delivery system of Naproxen was successfully developed by filling matrix-mini-tablets into an empty HPMC capsule shell for targeting early morning peak symptoms of rheumatoid arthritis

FORMULATION AND EVALUATION OF FAST DISSOLVING GRANISETRON HYDROCHLORIDE TABLETS: EFFECT OF FUNCTIONALITY OF SUPERDISINTEGRANTS

Fast dissolving tablets (FDT) of Granisetron hydrochloride were prepared by direct compression method after incorporating superdisintegrants croscarmellose sodium and crospovidone in different concentrations (2.5, 5, 7.5 and 10 mg). Eight formulations having superdisintegrants at different concentration level were prepared to assess their efficiency and critical concentration level. Different type of evaluation parameters for blends and tablets were used. The prepared tablets were characterized by FTIR studies. No chemical interaction between drug and exciepients was confirmed by FTIR studies. The formulation GCS4 containing croscarmellose sodium showed superior in vitro, in vitro dispersion time and drug release, as compared to other formulations. GCS4 tablet showed good dissolution efficiency and rapid dissolution.  The 50% and 90% of drug release of tablet GCS4, was found within 0.45 and 2.59 min