ESTIMATION OF LIPID PROFILE AND ASSESSMENT OF CARDIOVASCULAR RISK IN SMOKERS BY USING NEW ATHEROGENIC INDICES

Objective: Smoking habit leads to elevated levels of lipid profile thus increasing the cardiovascular disease risk in coronary heart disease. The aim ofstudy is undertaken to evaluate plasma lipid profile, of the male smoker with non-smoker's healthy matched control and assessing the cardiovascularrisk by using new atherogenic indices.Methods: Fasting blood samples were collected form both cases and controls and estimation of lipid profile by using by using autoanalyzer. A detailedphysical and anthropometric parameters information was collected form each participant subjects.Results: Plasma total cholesterol (TC) (221.52±8.34), triglyceride (TG) (274.94±28.70) low density lipoprotein cholesterol (LDL-c) (129.22±7.76),very LDL-c (VLDL-c) (54.98±5.74) and non-high-density lipoprotein cholesterol NonHDL-c (HDL-c) (183.26±7.58) in smokers subjects, which weresignificantly (p<0.0001) higher compared with non-smokers, while HDL-c significantly (38.25±1.34; p<0.001) decreased in smokers as comparedto non-smokers. Further, atherogenic ratios like, Castelli's risk index (CRI-I)=TC/HDL-c, CRI-II=LDL-c/HDL-c, atherogenic coefficient = (TC–HDL-c)/HDL-c TG/HDL-c ratio, and atherogenic index of plasma =log (TG/HDL-c) were calculated for individual subjects by using lipid profile. All these lipidratio are significantly (p<0.0001) in smoker group.Conclusion: Our conclusion, these ratio's could be used for identifying individual at higher risk of cardiovascular disease in the clinical practicesespecially, when the absolute values of lipid profile seem normal or higher and not markedly deranged or in centers with insufficient resources.Keywords: Cigarette smoking, Lipid profile, Cardiovascular risk, Atherogenic indices