2 research outputs found
Perspectives For Target Therapy In The Treatment Of Malignant Neoplasms Of The Urinary Bladder
ΠΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΡΠ°, ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π°ΡΠ° ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ΡΠΎ Π½Π° Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½ΠΈΡΠ΅ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΡΠ²Π°Π½ΠΈΡ Π½Π° ΠΏΠΈΠΊΠΎΡΠ½ΠΈΡ ΠΌΠ΅Ρ
ΡΡ Π²ΡΠ΅ ΠΎΡΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΄Π°Ρ ΡΠ΅Π΄ΠΈΡΠ° Π²ΡΠΏΡΠΎΡΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π΅Π½ΠΈ ΡΠ° Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΈ, ΠΏΠΎΠΊΠ°Π·Π²Π°ΡΠΈ ΡΠ°Π·Π»ΠΈΠΊΠΈ Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π½ΠΈΡ ΠΎΠ±ΡΠ°Π· Π½Π° ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΈΡ ΠΈ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΈΡ ΡΡΠΎΠ΅ΠΏΠΈΡΠ΅Π»Π΅Π½ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌ, ΠΊΠΎΠΈΡΠΎ ΡΠ° ΡΠ°ΡΡ ΠΎΡ ΡΠ°ΠΊΡΠΎΡΠΈΡΠ΅, ΠΎΡΠ³ΠΎΠ²ΠΎΡΠ½ΠΈ Π·Π° Π³ΠΎΠ»Π΅ΠΌΠΈΡΠ΅ Π²Π°ΡΠΈΠ°ΡΠΈΠΈ Π² Π»Π΅ΡΠ΅Π½ΠΈΠ΅ΡΠΎ Π΄ΠΎΡΠΈ ΠΈ ΠΏΡΠΈ ΡΡΠΌΠΎΡΠΈ Ρ Π΅Π΄Π½Π°ΠΊΡΠ² Ρ
ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅Π½ ΡΠ΅Π·ΡΠ»ΡΠ°Ρ. Π ΠΌΠΎΠΌΠ΅Π½ΡΠ° ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎ ΠΏΡΠΈΠ»Π°Π³Π°Π½Π°ΡΠ° ΡΠΈΡΡΠ΅ΠΌΠ½Π° ΡΠ΅ΡΠ°ΠΏΠΈΡ Π²ΠΊΠ»ΡΡΠ²Π° ΡΠ°Π·Π»ΠΈΡΠ½ΠΈ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΈ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ½ΠΈ ΡΡ
Π΅ΠΌΠΈ ΠΈ ΡΠ΅ ΠΎΡΠ½ΠΎΠ²Π°Π²Π° Π³Π»Π°Π²Π½ΠΎ Π½Π° Ρ
ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½Π°ΡΠ° ΠΎΡΠ΅Π½ΠΊΠ° ΠΈ ΡΡΠ°Π΄ΠΈΡΠ°Π½Π΅ΡΠΎ Π½Π° ΡΡΠΌΠΎΡΠ°. ΠΡ ΠΌΠ°ΠΉ 2016 Π³. Π·Π° ΠΏΡΡΠ²ΠΈ ΠΏΡΡ ΡΠ΅ ΡΠ°Π·ΡΠ΅ΡΠΈ ΠΏΡΠΈΠ»Π°Π³Π°Π½Π΅ΡΠΎ Π½Π° ΠΏΡΠΈΡΠ΅Π»Π½Π° ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π½Π° ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΠΈ Π·Π±ΠΎΠ»ΡΠ²Π°Π½ΠΈΡ Π½Π° ΠΏΠΈΠΊΠΎΡΠ΅Π½ ΠΌΠ΅Ρ
ΡΡ. ΠΡΠΈΡΠ΅Π»Π½Π°ΡΠ° ΡΠ΅ΡΠ°ΠΏΠΈΡ ΡΠ΅ ΠΈΠ·ΠΏΠΎΠ»Π·Π²Π° Π·Π° ΡΠΏΠΈΡΠ°Π½Π΅ Π½Π° ΡΠ°ΡΡΠ΅ΠΆΠ° ΠΈ ΡΠ°Π·ΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠ΅ΡΠΎ Π½Π° ΡΠ°ΠΊΠΎΠ²ΠΈΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ, ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΠΏΠΎΡΠΈΡΠΊΠ°Π½Π΅ Π½Π° Π°ΠΊΡΠΈΠ²ΠΈΡΠ°Π½ΠΈ ΡΠΈΠ³Π½Π°Π»Π½ΠΈ ΠΏΡΡΠΈΡΠ° - Π½Π°ΠΉ-ΡΠ΅ΡΡΠΎ Π½Π° ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΠ½ΠΈΡ, Π΅ΠΏΠΈΠ΄Π΅ΡΠΌΠ°Π»Π½ΠΈΡ ΠΈ Π΅Π½Π΄ΠΎΡΠ΅Π»Π½ΠΈΡ ΡΠ°ΡΡΠ΅ΠΆΠ΅Π½ ΡΠ°ΠΊΡΠΎΡ. ΠΠ·Π±ΠΎΡΡΡ Π½Π° βΠΏΡΠ°Π²ΠΈΠ»Π½ΠΎΡΠΎ` Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ ΡΠ΅ Π±Π°Π·ΠΈΡΠ° Π΄ΠΎ Π³ΠΎΠ»ΡΠΌΠ° ΡΡΠ΅ΠΏΠ΅Π½ Π²ΡΡΡ
Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ½Π°ΡΠ° Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° Π½Π° ΡΡΠΌΠΎΡΠ° ΠΈ Π½Π°Π»ΠΈΡΠΈΠ΅ Π½Π° ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΈ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΈ, ΠΏΠΎΠΊΠ°Π·Π²Π°ΡΠΈ Π²ΡΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΠ° Π·Π° ΠΏΡΠΈΠ»Π°Π³Π°Π½Π΅ Π½Π° Π΅Π΄Π½ΠΎ ΠΈΠ»ΠΈ Π΄ΡΡΠ³ΠΎ Π»Π΅ΠΊΠ°ΡΡΡΠ²ΠΎ.ΠΡΠ΅Π· ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡΠ΅ Π³ΠΎΠ΄ΠΈΠ½ΠΈ Π΅ ΠΏΠΎΡΡΠΈΠ³Π½Π°Ρ Π·Π½Π°ΡΠΈΡΠ΅Π»Π΅Π½ Π½Π°ΠΏΡΠ΅Π΄ΡΠΊ Π² Π΅ΡΠ°ΡΠ° Π½Π° ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π½Π°ΡΠ° Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ° ΠΈ ΠΏΡΠΈΡΠ΅Π»Π½Π°ΡΠ° ΡΠ΅ΡΠ°ΠΏΠΈΡ, ΠΊΠΎΠ΅ΡΠΎ Π½Π΅ΠΌΠΈΠ½ΡΠ΅ΠΌΠΎ Π²ΠΎΠ΄ΠΈ Π΄ΠΎ ΡΠ΄ΡΠ»ΠΆΠ°Π²Π°Π½Π΅ Π½Π° ΠΏΡΠ΅ΠΆΠΈΠ²ΡΠ΅ΠΌΠΎΡΡΡΠ° Π½Π° ΠΎΠ½ΠΊΠΎΠΏΠΎΡΠΈΠ΅Π½ΡΠΈΡΠ΅ ΠΈ ΠΏΠΎΠ΄ΠΎΠ±ΡΡΠ²Π°Π½Π΅ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΡΠΎ ΠΈΠΌ Π½Π° ΠΆΠΈΠ²ΠΎΡ. Π ΡΠ°Π·ΠΈ ΡΡΠ°ΡΠΈΡ Π½ΠΈΠ΅ ΡΠ°Π·Π³Π»Π΅ΠΆΠ΄Π°ΠΌΠ΅ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π½ΠΈΡΠ΅ ΠΈ ΡΡΡΠ΅ΡΡΠ²ΡΠ²Π°ΡΠΈΡΠ΅ Π²ΡΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ Π·Π° ΠΏΡΠΈΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π½Π° ΠΏΡΠ΅ΡΠΈΠ·ΠΈΡΠ°Π½Π° ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΏΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈ Ρ ΡΡΠΎΠ΅ΠΏΠΈΡΠ΅Π»Π½ΠΈ ΡΡΠΌΠΎΡΠΈ.The etiology, pathogenesis and treatment of malignant neoplasms of the bladder still address a number of issues. Several biomarkers have been identified showing differences in the molecular image of invasive and non-invasive uroepithelial carcinoma. These biomarkers are part of the factors responsible for the large variation in treatment even in tumors with the same histological diagnosis. Currently, standard systemic therapy includes various cytotoxic chemotherapy regimens and is based mainly on histological evaluation and tumor progression. Since May 2016, target therapy has been approved for the first time in the treatment of oncological bladder disease. Target therapy is used to stop the growth and spread of cancer cells by suppressing activated signaling pathways - most often fibroblast, epidermal and endothelial growth factor pathways. The choice of β the right` drug is largely based on the molecular genetic diagnosis of the tumor and the presence of specific biomarkers indicating the applicability of one or another drug.Significant progress has been made in the era of molecular diagnosis and target therapy, which leads to prolonged survival and improved quality of life of oncology patients. In this article, we examine the potential and existing options for the use of precision therapy in patients with uroeptithelial tumors
Istanbul Crisis In Bulgaria
Among the few countries in Europe which have not yet ratified the Istanbul Convention, Bulgaria presents quite an interesting case when it comes to the matter. From silently signing the document to it escalating to later triggering public unrest and crisis over the course of several years. However, as interesting as that process is, there is little to no academic research done on the matter.
The only data available on what happened appears to be in news articles. By analyzing this data to the theoretical framework, created by Benjamin Moffit, this paper aims to address this lack of information and identify whether or not a populist narrative is at work. The framework Moffitt has presented is used to identify crisis created by populist actors. The data and theories are combined by utilizing a qualitative content analysis.
It is determined that the framework proposed by Moffitt is viable and applicable to the case of Bulgaria. This opens up new academic opportunities as well as questions about the political dynamic and narrative in the country