Cognitive bias and the order of examination in forensic anthropological non-metric methods: a pilot study

Research has established that contextual information has the potential to influence the decisions of examiners in various forensic domains, including forensic anthropology. Studies have demonstrated that the non-metric sex estimation methods are susceptible to issues of cognitive bias, however the different types of stimuli that can influence the decision-making process remain understudied. As forensic anthropologists will examine multiple skeletal elements to estimate the sex of skeletal remains, a pilot study was designed to assess the potential of cognitive bias resulting from the order of examination. Two groups performed a non-metric sex estimation of the innominates and the skull with methods from Standards on one individual complete skeleton. Group A examined the skull first followed by the innominates, while Group B examined the innominates first followed by the skull. Results reveal a significant difference between the two groups in the sex estimation of the innominates and the complete skeleton (p = 0.020 and p = 0.022, respectively). This research demonstrates that order of examination for sex estimation may act as context and potentially influence the subsequent analyses. Additional research is necessary to broaden the understanding of decision-making and aid in the establishment of standard operating procedures designed to mitigate the potential effects of cognitive bias

Gamma-ray burst observations with new generation imaging atmospheric Cerenkov Telescopes in the FERMI era

After the launch and successful beginning of operations of the FERMI satellite, the topics related to high-energy observations of gamma-ray bursts have obtained a considerable attention by the scientific community. Undoubtedly, the diagnostic power of high-energy observations in constraining the emission processes and the physical conditions of gamma-ray burst is relevant. We briefly discuss how gamma-ray burst observations with ground-based imaging array Cerenkov telescopes, in the GeV-TeV range, can compete and cooperate with FERMI observations, in the MeV-GeV range, to allow researchers to obtain a more detailed and complete picture of the prompt and afterglow phases of gamma-ray bursts.Comment: 9 pages, two figures. Proceeding for the 6th "Science with the New Generation of High Energy Gamma-Ray Experiments" worksho

Novel technique for monitoring the performance of the LAT instrument on board the GLAST satellite

The Gamma-ray Large Area Space Telescope (GLAST) is an observatory designed to perform gamma-ray astronomy in the energy range 20 MeV to 300 GeV, with supporting measurements for gamma-ray bursts from 10 keV to 25 MeV. GLAST will be launched at the end of 2007, opening a new and important window on a wide variety of high energy astrophysical phenomena . The main instrument of GLAST is the Large Area Telescope (LAT), which provides break-through high-energy measurements using techniques typically used in particle detectors for collider experiments. The LAT consists of 16 identical towers in a four-by-four grid, each one containing a pair conversion tracker and a hodoscopic crystal calorimeter, all covered by a segmented plastic scintillator anti-coincidence shield. The scientific return of the instrument depends very much on how accurately we know its performance, and how well we can monitor it and correct potential problems promptly. We report on a novel technique that we are developing to help in the characterization and monitoring of LAT by using the power of classification trees to pinpoint in a short time potential problems in the recorded data. The same technique could also be used to evaluate the effect on the overall LAT performance produced by potential instrumental problems.Comment: 2 pages, 1 figure, manuscript submitted on behalf of the GLAST/LAT collaboration to First GLAST symposium proceeding

Sheep α-globin gene sequences: Implications for their concerted evolution and for the down-regulation of the 3' genes

In sheep as in man and most other mammals, there are two α-globin genes (Iα and IIα), which are expressed at different levels, the upstream gene being the most efficient. In α-globin gene triplication and quadruplication, this trend is confirmed, i.e., the α-chain output of the downstream genes progressively decreases. In this study, we have determined the complete sequence of the cDNAs and of both the introns in a triple-α haplotype in which each gene could be recognized for the presence of distinct alleles. The sequence analysis reveals that the bodies of the three α-globin genes are essentially identical (99.9% homology) and moreover indicates that the down-regulation of additional α-globin genes in sheep is not the effect of sequence variation from the Cap to the Poly(A) addition sites. This striking similarity among α-genes is higher than that seen in other mammals and is probably sustained by particularly efficient mechanisms of gene conversion and cross-over fixation

Evaluating intuitive decision-making in non-metric sex estimation from the cranium: an exploratory study

In recent years, forensic science has seen a rise in the number of multidisciplinary studies examining the effect of human cognition on the evaluation of forensic evidence. Notably, the House of Lords’ report highlighted the need for further investigation of the consequences of cognitive factors on decision-making processes involved in evidence evaluation and interpretation. Utilizing the concepts of intuitive and methodical decision-making, this pilot study investigated this dichotomy within the field of forensic anthropology, applied to sex estimation from the skull. Participants were asked to estimate the biological sex of six crania in two experiments: once ‘intuitively’ under time-pressure, and once by rationally applying the Acsádi and Nemeskéri method with no time-pressure. The potential influence of experience and its correlation with the participants’ confidence levels was also explored. The results demonstrate that intuitive and methodical evaluations can be consistent with each other, yet consistency decreases as ambiguity increases. Confidence was affected more by time availability, and less by level of experience. The insights from this exploratory study address how decision-making processes are involved in the examination of skeletal remains and offers justification for future exploration into the value of applying wider decision-making theories in the field of forensic anthropology

High energy emission from galaxy clusters and particle acceleration due to MHD turbulence

In the next years the FERMI gamma ray telescope and the Cherenkov telescopes will put very stringent constraints to models of gamma ray emission from galaxy clusters providing crucial information on relativistic particles in the inter-galactic-medium. We derive the broad band non-thermal spectrum of galaxy clusters in the context of general calculations in which relativistic particles (protons and secondary electrons due to proton-proton collisions) interact with MHD turbulence generated in the cluster volume during cluster mergers, and discuss the importance of future gamma ray observations.Comment: 9 pages, 2 figures, in proceedings of "Science with the new generation of high energy gamma ray experiments", AIP Conf. Proc. Series, D.Bastieri and R.Rando ed

Dietary Supplements and Nutraceuticals Under Investigation for COVID-19 Prevention and Treatment

Coronavirus disease 2019 (COVID-19) has caused global disruption and a significant loss of life. Existing treatments that can be repurposed as prophylactic and therapeutic agents could reduce the pandemic's devastation. Emerging evidence of potential applications in other therapeutic contexts has led to the investigation of dietary supplements and nutraceuticals for COVID-19. Such products include vitamin C, vitamin D, omega 3 polyunsaturated fatty acids, probiotics, and zinc, all of which are currently under clinical investigation. In this review, we critically appraise the evidence surrounding dietary supplements and nutraceuticals for the prophylaxis and treatment of COVID-19. Overall, further study is required before evidence-based recommendations can be formulated, but nutritional status plays a significant role in patient outcomes, and these products could help alleviate deficiencies. For example, evidence indicates that vitamin D deficiency may be associated with greater incidence of infection and severity of COVID-19, suggesting that vitamin D supplementation may hold prophylactic or therapeutic value. A growing number of scientific organizations are now considering recommending vitamin D supplementation to those at high risk of COVID-19. Because research in vitamin D and other nutraceuticals and supplements is preliminary, here we evaluate the extent to which these nutraceutical and dietary supplements hold potential in the COVID-19 crisis

Transfer RNA Genes Affect Chromosome Structure and Function via Local Effects

The genome is packaged and organized in an ordered, non-random manner and specific chromatin segments contact nuclear substructures to mediate this organization. Transfer RNA genes (tDNAs) are binding sites for transcription factors and architectural proteins and are thought to play an important role in the organization of the genome. In this study, we investigate the role of tDNAs in genomic organization and chromosome function by editing a chromosome so that it lacks any tDNAs. Surprisingly our analyses of this tDNA-less chromosome show that loss of tDNAs does not grossly affect chromatin architecture or chromosome tethering and mobility. However, loss of tDNAs affects local nucleosome positioning and the binding of SMC proteins at these loci. The absence of tDNAs also leads to changes in centromere clustering and a reduction in the frequency of long-range HML-HMR heterochromatin clustering with concomitant effects on gene silencing. We propose that the tDNAs primarily affect local chromatin structure that result in effects on long-range chromosome architecture