3 research outputs found
Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016
- Author
- Abajobir Amanuel Alemu
- Abate Kalkidan Hassen
- Abbafati Cristiana
- Abbas Kaja M.
- Abd-Allah Foad
- Abdulkader Rizwan Suliankatchi
- Abdulle Abdishakur M.
- Abera Semaw Ferede
- Aboyans Victor
- Abu-Raddad Laith J.
- Abu-Rmeileh Niveen M.E.
- Adedeji Isaac Akinkunmi
- Adetokunboh Olatunji
- Afshin Ashkan
- Agrawal Anurag
- Agrawal Sutapa
- Ahmadieh Hamid
- Ahmed Muktar Beshir
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Aiyar Sneha
- Akinyemi Rufus Olusola
- Akseer Nadia
- Al-Aly Ziyad
- Al-Raddadi Rajaa
- Alam Khurshid
- Alam Noore
- Alasfoor Deena
- Alene Kefyalew Addis
- Alizadeh-Navaei Reza
- Alkerwi Ala'a
- Alla François
- Allebeck Peter
- Allen Christine
- Alsharif Ubai
- Altirkawi Khalid A.
- Alvis-Guzman Nelson
- Amare Azmeraw T.
- Amini Erfan
- Ammar Walid
- Ansari Hossein
- Antonio Carl Abelardo T.
- Anwari Palwasha
- Arora Megha
- Artaman Al
- Arthur Avokpaho Euripide Frinel G.
- Aryal Krishna Kumar
- Asayesh Hamid
- Asgedom Solomon Weldegebreal
- Assadi Reza
- Atey Tesfay Mehari
- Atre Sachin R.
- Avila-Burgos Leticia
- Awasthi Ashish
- Azzopardi Peter
- Bacha Umar
- Badawi Alaa
- Balakrishnan Kalpana
- Bannick Marlena S.
- Barac Aleksandra
- Barber Ryan M.
- Barker-Collo Suzanne L.
- Barrero Lope H.
- Basu Sanjay
- Battle Katherine E.
- Baune Bernhard T.
- Beardsley Justin
- Bedi Neeraj
- Beghi Ettore
- Bell Michelle L.
- Bennett Derrick A.
- Bennett James R.
- Bensenor Isabela M.
- Berhane Adugnaw
- Berhe Derbew Fikadu
- Bernabé Eduardo
- Betsu Balem Demtsu
- Beuran Mircea
- Beyene Addisu Shunu
- Bhala Neeraj
- Bhansali Anil
- Bhatt Samir
- Bhutta Zulfiqar A.
- Bicer Burcu Kucuk
- Bidgoli Hassan Haghparast
- Bikbov Boris
- Bilal Arebu I.
- Birungi Charles
- Biryukov Stan
- Bizuayehu Habtamu Mellie
- Blancas Maria Jesus Rios
- Blosser Christopher D.
- Boneya Dube Jara
- Bose Dipan
- Bou-Orm Ibrahim R.
- Brauer Michael
- Breitborde Nicholas J.K.
- Brugha Traolach S.
- Bulto Lemma Negesa Bulto
- Butt Zahid A.
- BĂ€rnighausen Till
- BĂ©jot Yannick
- Cahuana-Hurtado Lucero
- Cameron Ewan
- Campuzano Julio Cesar
- Carabin HĂ©lĂšne
- Carrero Juan Jesus
- Carter Austin
- Casey Daniel C.
- Castañeda-Orjuela Carlos A.
- Castro Ruben Estanislao
- CatalĂĄ-LĂłpez FerrĂĄn
- Cercy Kelly
- Chang Hsing-Yi
- Chang Jung-Chen
- Charlson Fiona J.
- Chew Adrienne
- Chisumpa Vesper Hichilombwe
- Chitheer Abdulaal A.
- Christensen Hanne
- Christopher Devasahayam Jesudas
- Cirillo Massimo
- Cooper Cyrus
- Criqui Michael H.
- Cromwell Elizabeth A.
- Crump John A.
- CĂĄrdenas Rosario
- Dandona Lalit
- Dandona Rakhi
- Dargan Paul I.
- Das Neves José
- Davitoiu Dragos V.
- De Courten Barbora
- De Steur Hans
- Defo Barthelemy Kuate
- Degenhardt Louisa
- Deiparine Selina
- Deribe Kebede
- DeVeber Gabrielle A.
- Ding Eric L.
- Djalalinia Shirin
- Do Huyen Phuc
- Dokova Klara
- Doku David Teye
- Dorsey E. Ray
- Driscoll Tim R.
- Dubey Manisha
- Duncan Bruce Bartholow
- Ebel Beth E.
- Ebrahimi Hedyeh
- El Razek Hassan Magdy Abd
- El Razek Mohammed Magdy Abd
- El Sayed Zaki Maysaa
- El-Khatib Ziad Ziad
- Enayati Ahmadali
- Endries Aman Yesuf
- Ermakov Sergey Petrovich
- Erskine Holly E.
- Eshrati Babak
- Eskandarieh Sharareh
- Esteghamati Alireza
- Estep Kara
- Faraon Emerito Jose Aquino
- Faro André
- Farzadfar Farshad
- Fazeli Mir Sohail
- Feigin Valery L.
- Feigl Andrea B.
- Fereshtehnejad Seyed-Mohammad
- Fernandes JoĂŁo C.
- Ferrari Alize J.
- Feyissa Tesfaye Regassa
- Filip Irina
- Fischer Florian
- Fitzmaurice Christina
- Flaxman Abraham D.
- Foigt Nataliya
- Foreman Kyle J.
- Frank Tahvi
- Franklin Richard C.
- Friedman Joseph
- Frostad Joseph J.
- Fullman Nancy
- Furtado Joao M.
- FĂŒrst Thomas
- Gakidou Emmanuela
- Garcia-Basteiro Alberto L.
- Gebrehiwot Tsegaye Tewelde
- Geleijnse Johanna M.
- Geleto Ayele
- Gemechu Bikila Lencha
- Gething Peter W.
- Gibney Katherine B.
- Gill Paramjit Singh
- Gillum Richard F.
- Giref Ababi Zergaw
- Gishu Melkamu Dedefo
- Giussani Giorgia
- Glenn Scott D.
- Godwin William W.
- Goldberg Ellen M.
- Gona Philimon N.
- Goodridge Amador
- Gopalani Sameer Vali
- Goryakin Yevgeniy
- Griswold Max
- Gugnani Harish Chander
- Gupta Rajeev
- Gupta Tanush
- Gupta Vipin
- Hafezi-Nejad Nima
- Hailu Gessessew Bugssa
- Hamadeh Randah Ribhi
- Hammami Mouhanad
- Hankey Graeme J.
- Harb Hilda L.
- Hareri Habtamu Abera
- Hassanvand Mohammad Sadegh
- Havmoeller Rasmus
- Hawley Caitlin
- Hay Simon I.
- He Jiawei
- Hendrie Delia
- Henry Nathaniel J.
- Heredia-Pi Ileana Beatriz
- Hernandez Julio Cesar Montañez
- Hoek Hans W.
- Holmberg Mollie
- Horita Nobuyuki
- Hosgood H. Dean
- Hostiuc Sorin
- Hoy Damian G.
- Hsairi Mohamed
- Htet Aung Soe
- Huang Hsiang
- Huang John J.
- Huynh Chantal
- Iburg Kim Moesgaard
- Ikeda Chad
- Inoue Manami
- Irvine Caleb Mackay Salpeter
- Islam Sheikh Mohammed Shariful
- Jacobsen Kathryn H.
- Jahanmehr Nader
- Jakovljevic Mihajlo B.
- Jauregui Alejandra
- Javanbakht Mehdi
- Jeemon Panniyammakal
- Jha Vivekanand
- John Denny
- Johnson Catherine O.
- Johnson Sarah Charlotte
- Jonas Jost B.
- JĂŒrisson Mikk
- Kabir Zubair
- Kadel Rajendra
- Kahsay Amaha
- Kamal Ritul
- Karch André
- Karema Corine Kakizi
- Kasaeian Amir
- Kassebaum Nicholas J.
- Kastor Anshul
- Katikireddi Srinivasa Vittal
- Kawakami Norito
- Keiyoro Peter Njenga
- Kelbore Sefonias Getachew
- Kemmer Laura
- Kengne Andre Pascal
- Kesavachandran Chandrasekharan Nair
- Khader Yousef Saleh
- Khalil Ibrahim A.
- Khan Ejaz Ahmad
- Khang Young-Ho
- Khosravi Ardeshir
- Khubchandani Jagdish
- Kiadaliri Aliasghar Ahmad
- Kieling Christian
- Kim Daniel
- Kim Jun Y.
- Kim Yun Jin
- Kimokoti Ruth W.
- Kinfu Yohannes
- Kisa Adnan
- Kissimova-Skarbek Katarzyna A.
- Kivimaki Mika
- Kokubo Yoshihiro
- Kopec Jacek A.
- Kosen Soewarta
- Koul Parvaiz A.
- Koyanagi Ai
- Kravchenko Michael
- Krohn Kristopher J.
- Kulikoff Xie Rachel
- Kumar G. Anil
- Kutz Michael J.
- Kyu Hmwe H.
- Lal Dharmesh Kumar
- Lalloo Ratilal
- Lansingh Van C.
- Larsson Anders
- Lazarus Jeffrey Victor
- Lee Paul H.
- Leigh James
- Leung Janni
- Leung Ricky
- Levi Miriam
- Li Yongmei
- Liben Misgan Legesse
- Lim Stephen S.
- Linn Shai
- Liu Patrick Y.
- Liu Shiwei
- Lodha Rakesh
- Looker Katharine J.
- Lopez Alan D.
- Lorkowski Stefan
- Lotufo Paulo A.
- Lozano Rafael
- Lucas Timothy C.D.
- Lunevicius Raimundas
- Mackay Mark T.
- Maddison Emilie R.
- Mahesh
- Majdan Marek
- Majdzadeh Reza
- Majeed Azeem
- Malekzadeh Reza
- Malhotra Rajesh
- Malta Deborah Carvalho
- Mamun Abdullah A.
- Manguerra Helena
- Mantovani Lorenzo G.
- Manyazewal Tsegahun
- Mapoma Chabila C.
- Marks Guy B.
- Martin Randall V.
- Martinez-Raga Jose
- Martins-Melo Francisco RogerlĂąndio
- Martopullo Ira
- Mathur Manu Raj
- Mazidi Mohsen
- McAlinden Colm
- McGaughey Madeline
- McGrath John J.
- McKee Martin
- Mehata Suresh
- Mehndiratta Man Mohan
- Meier Toni
- Meles Kidanu Gebremariam
- Memish Ziad A.
- Mendoza Walter
- Mengesha Melkamu Merid
- Mengistie Mubarek Abera
- Mensah George A.
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- Mereta Seid Tiku
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- Mezgebe Haftay Berhane
- Micha Renata
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- Misganaw Awoke
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- Mohammad Karzan Abdulmuhsin
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- Monasta Lorenzo
- Montico Marcella
- Moradi-Lakeh Maziar
- Moraga Paula
- Morawska Lidia
- Morrison Shane D.
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- Mountjoy-Venning Cliff
- Mueller Ulrich O.
- Muller Kate
- Murray Christopher J.L.
- Murthy Gudlavalleti Venkata Satyanarayana
- Musa Kamarul Imran
- Naghavi Mohsen
- Naheed Aliya
- Naidoo Kovin S.
- Nangia Vinay
- Natarajan Gopalakrishnan
- Negoi Ionut
- Negoi Ruxandra Irina
- Nguyen Cuong Tat
- Nguyen Grant
- Nguyen Minh
- Nguyen Quyen Le
- Nguyen Trang Huyen
- Nichols Emma
- Ningrum Dina Nur Anggraini
- Nomura Marika
- Nong Vuong Minh
- Norheim Ole F.
- Noubiap Jean Jacques N.
- Obermeyer Carla Makhlouf
- Ogbo Felix Akpojene
- Oh In-Hwan
- Oladimeji Olanrewaju
- Olagunju Andrew Toyin
- Olagunju Tinuke Oluwasefunmi
- Olivares Pedro R.
- Olsen Helen E.
- Olusanya Bolajoko Olubukunola
- Olusanya Jacob Olusegun
- Ong Kanyin
- Oren Eyal
- Ortiz Alberto
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- Panda Basant Kumar
- Panda-Jonas Songhomitra
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- Park Eun-Kee
- Patton George C.
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- Pereira David M.
- Perico David Norberto
- Pesudovs Konrad
- Petzold Max
- Phillips Michael Robert
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- Pillay Julian David
- Pinho Christine
- Piradov Michael A.
- Pishgar Farhad
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- Pourmalek Farshad
- Qorbani Mostafa
- Radfar Amir
- Rafay Anwar
- Rahimi-Movaghar Vafa
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- Reidy Patrick
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- Reitsma Marissa B.
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- Renzaho Andre M.N.
- Resnikoff Serge
- Rezaei Satar
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- Roba Kedir Teji
- Rojas-Rueda David
- Rokni Mohammad Bagher
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- Rubagotti Enrico
- Sadat Nafis
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- Satpathy Maheswar
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- Shahraz Saeid
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- Shi Peilin
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- Silva Diego Augusto Santos
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- Silveira Dayane Gabriele Alves
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- Sinha Dhirendra Narain
- Skiadaresi Eirini
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- Tabarés-Seisdedos Rafael
- Tadakamadla Santosh Kumar
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- Tavakkoli Mohammad
- Taveira Nuno
- Tegegne Teketo Kassaw
- Terkawi Abdullah Sulieman
- Tessema Gizachew Assefa
- Thakur
- Thankappan Kavumpurathu Raman
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- Tiruye Tenaw Yimer
- Tobe-Gai Ruoyan
- Topor-Madry Roman
- Torre Anna
- Tortajada Miguel
- Tran Bach Xuan
- Troeger Christopher
- Truelsen Thomas
- Tsoi Derrick
- Tuem Kald Beshir
- Tuzcu Emin Murat
- Tyrovolas Stefanos
- Ukwaja Kingsley N.
- Uneke Chigozie Jesse
- Updike Rachel
- Ur Rahman Mohammad Hifz
- Uthman Olalekan A.
- Van Boven Job F.M.
- Van Donkelaar Aaron
- Varughese Santosh
- Vasankari Tommi
- Venketasubramanian Narayanaswamy
- Vidavalur Ramesh
- Violante Francesco S.
- Vladimirov Sergey K.
- Vlassov Vasiliy Victorovich
- Vollset Stein Emil
- Vos Theo
- Wadilo Fiseha
- Wakayo Tolassa
- Wallin Mitchell T.
- Wang Yuan-Pang
- Weichenthal Scott
- Weiderpass Elisabete
- Weintraub Robert G.
- Weiss Daniel J.
- Werdecker Andrea
- Westerman Ronny
- Whiteford Harvey A.
- Wijeratne Tissa
- Wiysonge Charles Shey
- Woldeyes Belete Getahun
- Wolfe Charles D.A.
- Woodbrook Rachel
- Xavier Denis
- Xu Gelin
- Yadgir Simon
- Yakob Bereket
- Yan Lijing L.
- Yano Yuichiro
- Yaseri Mehdi
- Ye Pengpeng
- Yimam Hassen Hamid
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z.
- Zaidi Zoubida
- Zavala-Arciniega Luis
- Zhang Xueying
- Zipkin Ben
- Zodpey Sanjay
- Publication venue
- Publication date
- 01/01/2017
- Field of study
The UNâs Sustainable Development Goals (SDGs) are grounded in the global ambition of âleaving no one behindâ. Understanding todayâs gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicators over the period 1990â2016 for 188 countries, and then on the basis of these past trends, we projected indicators to 2030
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
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- Frossard R.
- Fu M. (Mao)
- Gaget S. (Stefan)
- Ganser M. (Martha)
- Gardezi A. (Ali)
- Gejman P.V. (Pablo)
- Geus E.J. (Eeco)
- Gieger C. (Christian)
- Gigante B. (Bruna)
- Girelli D. (Domenico)
- Gjesing A.P. (Anette)
- Glass D. (Daniel)
- Glazer N.L. (Nicole)
- Gloyn A.L. (Anna)
- Goddard M.E. (Michael E.)
- Goddard M.E. (Michael)
- Goel A. (Anuj)
- Goodall A.H. (Alison)
- Goyette P. (Philippe)
- Grallert H. (Harald)
- Grarup N. (Niels)
- Green F. (Fiona)
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- Greenawalt D.M. (Danielle M.)
- Griffin S. (Simon)
- Groop L. (Leif)
- Groop L. (Leif)
- Groop L. (Leif)
- Groves C.J. (Christopher)
- Grundberg E. (Elin)
- GrĂ€sler J. (JĂŒrgen)
- Grönberg H. (Henrik)
- Gu H.F. (Harvest F.)
- Gudnason V. (Vilmundur)
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- Guiducci C. (Candace)
- Gulcher J.R. (Jeffrey)
- Gustafsson S. (Stefan)
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- Hadjadj S. (Samy)
- Haeften T.W. (Timon) van
- Hagen K. (Knut)
- Hall A.S. (Alistair S.)
- Hall P. (Per)
- Halperin E. (Eran)
- Hammond C.J. (Christopher J.)
- Hammond C.J. (Christopher)
- Hammond N. (Naomi)
- Hamsten A. (Anders)
- Hansen T. (T.)
- Haritunians T. (Talin)
- Harris T.B. (Tamara)
- Hartikainen A.-L. (Anna-Liisa)
- Hassanali N. (Neelam)
- Hattersley A.T. (Andrew)
- Havulinna A.S. (Aki)
- Hayes R.B. (Richard)
- Hayes R.B. (Richard)
- Hayward C. (Caroline)
- Hazen S.L. (Stanley)
- Heard-Costa N.L. (Nancy)
- Heath A.C. (Andrew C.)
- Hebebrand J. (Johannes)
- Hedman A.K. (Asa)
- Heid I.M. (Iris)
- Heijer M. (Martin) den
- Heinrich J. (Joachim)
- Hellénius M.-L. (Mai-Lis)
- Hengstenberg C. (Christian)
- Herder C. (Christian)
- Herpt T.W. (Thijs) van
- Hicks A.A. (Andrew)
- Hide W.A. (Winston)
- Hinney A. (Anke)
- Hirschhorn J.N. (Joel)
- Hitman G.A. (Graham)
- Hoek M. (Mandy) van
- Hoesel V. (Volker)
- Hofman A. (Albert)
- Hofmann O.M. (Oliver)
- Holm H. (Hilma)
- Homuth G. (Georg)
- Hopewell J.
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- Hottenga J.J. (Jouke Jan)
- Hu F.B. (Frank)
- Hui J. (Jennie)
- Huikuri H.V. (Heikki)
- Hunter D.J. (David J.)
- Huth C. (Cornelia)
- Hveem K. (Kristian)
- Igl W. (Wilmar)
- Illig T. (Thomas)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Iribarren C. (Carlos)
- Ishaq M. (Muhammad)
- Isomaa B. (Bo)
- Jackson A.U. (Anne)
- Jacobs K.B. (Kevin)
- James A. (Alan)
- Jameson K. (Karen)
- Jansson J.-O. (John-Olov)
- Jarick I. (Ivonne)
- Jarvelin M.-R. (Marjo-Riitta)
- Jewell E. (Eelizabeth)
- Johansson A. (Asa)
- John U. (Ulrich)
- Johnson P. (Paul)
- Johnson P.R.V. (Paul R.V.)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Jones G.T. (Gregory)
- Jorgensen T. (Torben)
- Jousilahti P. (Pekka)
- Jukema J.W. (Jan Wouter)
- Jula A. (Antti)
- Kaakinen M. (Marika)
- Kajantie E. (Eero)
- Kanoni S. (Stavroula)
- Kao W.H.L. (Wen)
- Kaplan L. (Lee)
- Kaplan R.C. (Robert)
- Kaprio J. (Jaakko)
- Kaprio J. (Jaakko)
- Karpe F. (Fredrik)
- Karpe F. (Fredrik)
- Kastelein J.J.P. (John)
- Kathiresan S. (Sekar)
- Kerr-Conte J. (Julie)
- Kettunen J. (Johannes)
- Khaw K.T.
- Kiemeney L.A.L.M. (Bart)
- KilpelÀinen T.O. (Tuomas)
- Klopp N. (Norman)
- Knowles J.W. (Joshua)
- Kolovou G. (Genovefa)
- Kong A. (Augustine)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Krude H.
- Kutalik Z. (ZoltĂĄn)
- Kuusisto J. (Johanna)
- Kyriakou T. (Theodosios)
- KÀhönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Laitinen J. (Jaana)
- Lambrechts D. (Diether)
- Lamina C. (Claudia)
- Langenberg C. (Claudia)
- Lantieri O. (Olivier)
- Lanzani C. (Chiara)
- Launer L.J. (Lenore)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lawrence R.W. (Robert)
- Lecoeur C. (CĂ©cile)
- LehtimÀki T. (Terho)
- Lettre G. (Guillaume)
- Levinson D.F. (Douglas F.)
- Levinson D.F. (Douglas)
- Li M. (Man)
- Li S. (Shengxu)
- Li X. (Xiaohui)
- Liang L. (Liming)
- Lieb W. (Wolfgang)
- Lieverse A.G. (Aloysius)
- Linksted P. (Pamela)
- Liu J. (Jianjun)
- Liu J. (Jianjun)
- Lokki M.L.
- Loley C. (Christina)
- Loos R.J.F. (Ruth)
- Lorentzon M. (Mattias)
- Lotery A.J. (Andrew)
- Luan J.
- Ludwig B. (Barbara)
- Lyssenko V. (Valeriya)
- Macciardi F. (Fabio)
- Makrilakis K. (Konstantinos)
- Mallick C.B. (Chandana Basu)
- Mannila M.N. (Maria Nastase)
- Manning A.K. (Alisa)
- Mannucci P.M. (Pier)
- Manunta P. (Paolo)
- Maouche S. (Seraya)
- Marek D. (Diana)
- Marre M. (Michel)
- Martin N.G. (Nicholas)
- Martinez-Larrad M.T. (Maria Teresa)
- McCarroll S.A. (Steven)
- McCarthy A. (Anne)
- McCarthy M. (Mark)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura)
- McKnight B. (Barbara)
- McPherson R. (Ruth)
- Meigs J.B. (James)
- Meisinger C. (Christa)
- Meitinger T. (Thomas)
- Melander O. (Olle)
- Merlini P.A. (Pier Angelica)
- Metspalu A. (Andres)
- Meyre D. (David)
- Midthjell K. (Kristian)
- Min J. (Josine)
- Mohlke K.L. (Karen L.)
- Monda K.L. (Keri)
- Montgomery G.W. (Grant)
- Montgomery G.W. (Grant)
- Mooser V. (Vincent)
- Morgan T. (Thomas)
- Morken M.A. (Mario)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew)
- Muhlestein J.B. (Joseph)
- Mulic R. (Rosanda)
- Munroe P. (Patricia)
- Munroe P.B. (Patricia B.)
- Munzel T. (Thomas)
- Musunuru K. (Kiran)
- Myers R.H. (Richard)
- MĂ€gi R. (Reedik)
- MĂ€larstig A. (Anders)
- MĂ€rz W. (Winfried)
- Nahrstaedt J. (Janja)
- Narisu N. (Narisu)
- Narisu N. (Narisu)
- Navarro P. (Pau)
- Nelis M. (Mari)
- Nelson C.P. (Christopher P.)
- Nemesh J. (James)
- Nestle F.O. (Frank)
- Neville M.J. (Matthew)
- Ngwa J.S.
- Nica A. (Alexandra)
- Nieminen M.S. (Markku)
- Nilsson P. (Peter)
- Nisbet J. (James)
- North K.E. (Kari)
- Nyholt D.R. (Dale)
- Nöthen M.M. (Markus)
- O'Connell J.R. (Jeffrey R.)
- O'Donnell C.J. (Christopher)
- O'Rahilly S. (Stephen)
- O'Rahilly S. (Stephen)
- O'Rahilly S. (Steve)
- Offer A. (Alison)
- Ohlsson C. (Claes)
- Olivieri O. (Oliviero)
- Olsson G.
- Ongen H. (Halit)
- Oostra B.A. (Ben)
- Osmond C. (Clive)
- Ouwehand W.H. (Willem)
- Owen K.R. (Katharine)
- OÂŽConnell J.R.
- Palmer C.N.A. (Colin)
- Pankow J.S. (James)
- Pare G. (Guillame)
- Park J.H.
- Parker A.N. (Alex)
- Parts L. (Leopold)
- Pascoe L. (Laura)
- Patel R.S. (Riyaz)
- Patterson C.C. (Chris C.)
- Payne F. (Felicity)
- Peden J. (John)
- Pedersen O. (Oluf)
- Pellikka N. (Niina)
- Peltonen L. (Leena Johanna)
- Penninx B.W.J.H.
- Perola M. (Markus)
- Perola M. (Markus)
- Perry J.R.B. (John)
- Peters A. (Annette)
- Peters M.J. (Marjolein)
- Petersen A.K.
- Peto R. (R.)
- Petrie J.R. (John)
- Peyvandi F. (Flora)
- Pichler I. (Irene)
- Pietilainen K.H. (Kirsi Hannele)
- Platou C. (Carl)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Potter S.C. (Simon)
- Pramstaller P.P. (Peter P.)
- Preuss M. (Michael)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Purcell S. (Shaun)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quyyumi A.A. (Arshed)
- Rader D.J. (Daniel)
- Rafelt S. (Suzanne)
- Raitakari O. (Olli)
- Raitakari O.T. (Olli T.)
- Rallidis L.S. (Loukianos)
- Randall J.C. (Joshua)
- Rasheed A. (Asif)
- Rathmann W. (Wolfgang)
- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (N. William)
- Rayner N.W. (Nigel William)
- Reilly M.P. (Muredach P.)
- Reinehr T. (Thomas)
- RidderstrÄle M. (Martin)
- Ridker P.M. (Paul)
- Rij A.M. (Andre) van
- Ripatti S. (Samuli)
- Rissanen A. (Aila)
- Rivadeneira Ramirez F. (Fernando)
- Roberts R. (Robert)
- Rocheleau G. (Ghislain)
- Roden M. (Michael)
- Rosendaal F.R. (Frits R.)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Rust S. (Stephan)
- Rybin D. (Denis)
- Rzehak P. (Peter)
- Sabater-Lleal M. (Maria)
- Saleheen D. (Danish)
- Salomaa V. (Veikko)
- Samad A. (Adbus)
- Samani N.J. (Nilesh)
- Samani N.J. (Nilesh)
- Sampietro M.L. (Maria Lourdes)
- Sampson M.J. (Michael)
- Samuel M. (Maria)
- Sanders A.R. (Alan R.)
- Sandholt C. (Camilla)
- Sandhu M.S. (Manjinder)
- Sandhu M.S. (Manjinder)
- Sanna S. (Serena)
- Saramies J. (Jouko)
- Savolainen M.J. (Markku)
- Saxena R. (Richa)
- Sayer A.A.
- Schadt E.E. (Eric)
- Scherag A. (Andre)
- Schillert A. (Arne)
- Schipf S. (Sabine)
- Schlessinger D. (David)
- Schreiber S. (Stefan)
- Schrezenmeir J. (JĂŒrgen)
- Schunkert H. (Heribert)
- Schwartz S.M. (Stephen)
- Schwarz P.E.H. (Peter)
- SchÀfer A. (Arne)
- Scott J. (James)
- Scott L.J. (Laura)
- Scott L.J. (Laura)
- Seedorf U. (Udo)
- SegrĂš A.V. (Ayellet)
- Sehmi J.S. (Joban)
- Sekowska M. (Magdalena)
- Sennblad B. (Bengt)
- Serrano-RĂos M. (Manuel)
- Shah N. (Nisha)
- Shi J. (Jianxin)
- Shi J. (Jianxin)
- Shields B.M. (Beverley)
- Shields B.M. (Beverley)
- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
- Shuldiner A.R. (Alan)
- Sigurdsson G. (Gunnar)
- Sijbrands E. (Eric)
- Sijbrands E.J.G. (Eric)
- Silander K. (Kaisa)
- Sinisalo J. (Juha)
- Siscovick D.S. (David)
- Sivapalaratnam S. (Suthesh)
- Sladek R. (Rob)
- Sleight P. (Peter)
- Smit J.H. (Jan)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith T.B. (Tamara B.)
- Snoep J.D. (Jaapjan)
- Soranzo N. (Nicole)
- SparsĂž T. (Thomas)
- Spector T.D. (Timothy)
- Speliotes E.K. (Elizabeth)
- Spertus J.A. (John)
- StanÄcĂĄkovĂĄ A. (Alena)
- Stark K. (Klaus)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Stephens J. (Jonathan)
- Stewart A.F. (Alexandre F.)
- Stirrups K. (Kathy)
- Stoll M. (Monika)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Strawbridge R.J. (Rona)
- Strawbridge R.J. (Rona)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Sun Q. (Qi)
- Surdulescu G. (Gabriela)
- Swift A.J. (Amy)
- SyvÀnen A.C.
- Tammesoo M.L.
- Taneera J. (Jalal)
- Tang W. (W.)
- Tardif J.-C. (Jean-Claude)
- Tennstedt S. (Stephanie)
- Teslovich T.M. (Tanya M.)
- Thiering E. (Eelisabeth)
- Thiering E. (Elisabeth)
- Thompson J.R. (John)
- Thomson B. (Brian)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorgeirsson G. (Gudmundur)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas)
- Tognoni G.
- Tomaszewski M. (Maciej)
- Travers M.E. (Mary E.)
- Travers M.E. (Mary)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Turrini F. (Fabiola)
- Tyrer J.P. (Jonathan)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- Van Dam R.M. (Rob M.)
- van't Hooft F. (Ferdinand)
- Van't Hooft F. (Ferdinand)
- Vatin V. (Vincent)
- Vedantam S. (Sailaja)
- Visscher P.M. (Peter M.)
- Visscher P.M. (Peter)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Voight B.F. (Benjamin)
- Wabitsch M. (Martin)
- Waeber G. (GĂ©rard)
- Waite L. (Lindsay)
- Walker M. (Mark)
- Wallaschofski H. (Henri)
- Walters G.B. (Bragi)
- Wareham N.J. (Nicholas J.)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R. (Ryan)
- Welch R.P. (Ryan)
- Wells G.A. (George)
- Weyant R.J. (Robert)
- Wheeler E. (Eleanor)
- White C.C. (Charles)
- Wichmann H.-E. (H-Erich)
- Wichmann H.E. (Heinz Erich)
- Widen E. (Elisabeth)
- Wiegand S. (Susanna)
- Wijmenga C. (Cisca)
- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
- Wild S.H. (Sarah)
- Wilk A. (Alicja)
- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Ăhrvik J. (John)
- Ăstenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 Ă 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 Ă 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 Ă 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals
- Author
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Gonçalo R.)
- Abecasis G.R. (Gonçalo)
- Adair L.S. (Linda)
- Allison M.A. (Matthew)
- Altshuler D. (David)
- Altshuler D. (David)
- Amin N. (Najaf)
- An P. (Ping)
- Ardlie K.G. (Kristin)
- Ardlie K.G. (Kristin)
- Ariyurek Y. (Yavuz)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii)
- Bacquer O.L. (Olivier)
- Balkau B. (Beverley)
- Balkau B. (Beverley)
- Ballantyne C. (Christie)
- Ballantyne C.M. (Christie M.)
- Ballantyne C.M. (Christie M.)
- Bandinelli S. (Stefania)
- Bandinelli S. (Stefania)
- Barbalic M. (maja)
- Barroso I.
- Barroso I.E. (InĂȘs)
- Barroso I.E. (InĂȘs)
- Barter P. (Phil)
- Beekman M. (Marian)
- Beilby J.P. (John)
- Ben-Shlomo Y.
- Benediktsson R. (Rafn)
- Benediktsson R. (Rafn)
- Bennett A.J. (Amanda)
- Bennett A.J. (Amanda)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Bidulescu A. (Aurelian)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Bochud M. (Murielle)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boehnke M. (Michael)
- Boehnke M. (Michael)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E. (Eric)
- Boerwinkle E. (Eric)
- Boerwinkle E.A. (Eric)
- Bonnefond A. (Amélie)
- Bonnycastle L.L. (Lori L.)
- Bonnycastle L.L. (Lori L.)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret I)
- Boomsma D.I. (Dorret I.)
- Boomsma D.I. (Dorret)
- Borch-Johnsen K.
- Borecki I.B. (Ingrid B)
- Borja J.B. (Judith)
- Boström K.B. (Kristina Bengtsson)
- Bouatia-Naji N. (Nabila)
- Bravenboer B. (Bert)
- Brunner E. (Eric)
- Buchanan T.A. (Thomas)
- Bumpstead S. (Suzannah)
- Bumpstead S. (Suzannah)
- Burtt N.P. (Noël P.)
- Burtt N.P. (Noël)
- Buxbaum S.G. (Sarah)
- Böhringer S. (Stefan)
- Böttcher Y. (Yvonne)
- Campbell H. (Harry)
- Campbell H. (Harry)
- Campbell H. (Harry)
- Cao A. (Antonio)
- Carlson O.D. (Olga)
- Cauchi S. (Stephane)
- Caulfield M. (Mark)
- Caulfield M.J. (Mark J.)
- Cavalcanti-Proença C. (Christine)
- Chambers J. (John)
- Chambers J.C. (John C.)
- Charpentier G. (Guillaume)
- Charpentier G. (Guillaume)
- Chasman D.I. (Daniel)
- Chen I. (Ida)
- Chen Y.-D.I. (Yii-Der Ida)
- Chen Y.D.I. (Yii-Der Ida)
- Chines P.S. (Peter S.)
- Chines P.S. (Peter)
- Cho Y.S. (Yoon Shin)
- Clarke R. (Robert)
- Coassin S. (Stefan)
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis)
- Cooper C. (Charles)
- Cooper C. (Cyrus)
- Cooper M.N. (Matthew)
- Cornelis M. (Marilyn)
- Cornelis M. (Marilyn)
- Couper D.J. (David J.)
- Couper D.J. (David)
- Crawford G. (Gabe)
- Crawford G. (Gabe)
- Crawford G. (Gabriel)
- Crisponi L. (Laura)
- Croteau-Chonka D.C. (Damien)
- Daly M.J. (Mark)
- Dam R.M. (Rob) van
- Dastani Z. (Zari)
- Day I.N.M. (Ian)
- Dedoussis G.V. (George)
- Dehghan A. (Abbas)
- Deloukas P. (Panagiotis)
- Deloukas P. (Panagiotis)
- Delplanque J. (Jerome)
- DIAGRAM+ Consortium
- Dina C. (Christian)
- Dina C. (Christian)
- Dominiczak A. (Anna)
- Dominiczak A.F. (Anna F.)
- Doney A.S.F. (Alex S. F.)
- Doney A.S.F. (Alex)
- Duijn C.M. (Cornelia) van
- Duncan B.B. (Bruce)
- Dupuis J. (Josée)
- Dupuis J. (Josée)
- Dupuis J. (Josée)
- Döring A. (Angela)
- Ebrahim S. (Shanil)
- Egan J.M. (Josephine)
- Egan J.M. (Josephine)
- Ejebe K.G. (Kenechi)
- Elliott A.L. (Amanda)
- Elliott A.L. (Amanda)
- Elliott K.S. (Katherine)
- Elliott P. (Paul)
- Erdmann J. (Jeanette)
- Erdmann J. (Jeanette)
- Erdos M.R. (Michael)
- Erdos M.R. (Michael)
- Evans D.M. (David)
- Faire U. (Ulf) de
- Fedson A.C. (Annette)
- Feitosa M.F. (Mary Furlan)
- Ferreira T. (Teresa)
- Ferrucci L. (Luigi)
- Ferrucci L. (Luigi)
- Fischer-Rosinsky A. (Antje)
- Florez J.C. (Jose C.)
- Florez J.C. (Jose)
- Florez J.C. (Jose)
- Forouhi N.G. (Nita)
- Fouchier S.W. (Sigrid)
- Fox C.S. (Caroline)
- Fox C.S. (Caroline)
- Franklin C.S. (Christopher)
- Franklin C.S. (Christopher)
- Franks P.W. (Paul)
- Frants R. (Rune)
- Frants R.R. (Rune)
- Franzosi M.
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy)
- Froguel P. (Philippe)
- Froguel P. (Philippe)
- Fuchsberger C. (Christian)
- Gabriel S.B. (Stacey)
- Galan P. (Pilar)
- Ganser M. (Martha)
- Garcia M.E. (M.)
- Geus E.J.C. (Eco) de
- Gieger C. (Christian)
- Gieger C. (Christian)
- Gieger C. (Christian)
- Gieger C. (Christian)
- Glazer N.L. (Nicole)
- GLGC Investigators
- Gloyn A.L. (Anna L.)
- Gloyn A.L. (Anna)
- Go M.J. (Min Jin)
- Goel A. (Anuj)
- Gonzalez E. (Elena)
- Goodarzi M. (Mark)
- Graessler J. (JĂŒrgen)
- Grallert H. (Harald)
- Grallert H. (Harald)
- Grarup N. (Niels)
- Grarup N. (Niels)
- Green T. (Todd)
- Greenwood C.M.T. (Celia)
- Griffin S. (Simon)
- Grimsby J. (Jonna)
- Groop L. (Leif)
- Groop L. (Leif)
- Groop L. (Leif)
- Groves C.J. (Christopher)
- Groves C.J. (Christopher)
- Grundy S.M. (Scott)
- Gudnason V. (Vilmundur)
- Guiducci C. (Candace)
- Guiducci C. (Candace)
- Guo X. (Xiuqing)
- Guo X. (Xiuqing)
- Gwilliam R. (Rhian)
- Gyllensten U. (Ulf)
- Gyllensten U. (Ulf)
- Gyllensten U. (Ulf)
- Hadjadj S. (Samy)
- Hadjadj S. (Samy)
- Haeften T.W. (Timon) van
- Hagen K. (Knut)
- Hall A.S. (Alistair)
- Hallmans G. (Göran)
- Hammond N. (Naomi)
- Hamsten A. (Anders)
- Han X. (Xijing)
- Hansen T. (Torben)
- Haritunians T. (Talin)
- Harris T.B. (Tamara B.)
- Harris T.B. (Tamara)
- Hartikainen A.L.
- Hassanali N. (Neelam)
- Hassanali N. (Neelam)
- Hastie N. (Nick)
- Hattersley A.T. (Andrew)
- Haun M. (Margot)
- Havulinna A.S. (Aki)
- Hayward C.
- Hayward C. (Caroline)
- Heath S.C. (Simon)
- Heemst D. (Diana) van
- Hegele R.A. (Robert)
- Heid I.M. (Iris)
- Heid I.M. (Iris)
- Hengstenberg C. (Christian)
- Henneman P. (Peter)
- Henneman P. (Peter)
- Hercberg S. (Serge)
- Herder C. (Christian)
- Herder C. (Christian)
- Herpt T.W. (Thijs) van
- Hicks A.A. (Andrew A.)
- Hicks A.A. (Andrew)
- Hide W.A. (Winston)
- Hillman D.R. (David)
- Hingorani A. (Aroon)
- Hitman G.A. (Graham)
- Hivert M.-F. (Marie-France)
- Hoek M. (Mandy) van
- Hofman A.
- Hofman A. (Albert)
- Hofman A. (Albert)
- Hofman A. (Albert)
- Hofmann O.M. (Oliver)
- Holm H. (Hilma)
- Hottenga J.J. (Jouke Jan)
- Hottenga J.J. (Jouke Jan)
- Hovingh G.K. (Kees)
- Hu F.B. (Frank B)
- Hu F.B. (Frank B.)
- Hu F.B. (Frank)
- Hui J. (Jennie)
- Hung J. (Joe)
- Hunter D.J. (David)
- Huth C. (Cornelia)
- Hveem K. (Kristian)
- Igl W. (Wilmar)
- Illig T. (Thomas)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Ingelsson E. (Erik)
- Ingelsson E. (Erik)
- Isaacs A. (Aaron)
- Isaacs A.J. (Aaron)
- Isomaa B. (Bo)
- Isomaa B. (Bo)
- Jackson A.U. (Anne)
- Jackson A.U. (Anne)
- Jarvelin M.-R. (Marjo-Riitta)
- Jarvelin M.-R. (Marjo-Riitta)
- Jarvelin M.-R. (Marjo-Riitta)
- Johansen C.T. (Christopher)
- Johansson A. (Ă sa)
- Johnson P.R.V. (Paul R. V.)
- Johnson P.R.V. (Paul)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Jorgensen T. (Torben)
- Jorgensen T. (Torben)
- Jula A. (Antti)
- Jula A. (Antti)
- Kaakinen M. (Marika)
- Kanaya A. (Alka)
- Kanoni S. (Stavroula)
- Kanoni S. (Stavroula)
- Kao W.H.L. (W. H. Linda)
- Kao W.H.L. (Wen H. L.)
- Kao W.H.L. (Wen)
- Kao W.H.L. (Wen)
- Kaplan L. (Lee)
- Kaprio J. (Jaakko)
- Kapur K. (Karen)
- Karpe F. (Fredrik)
- Kastelein J.J.P. (John)
- Katsareli E. (Efi)
- Kedenko L. (Lyudmyla)
- Kesaniemi Y.A. (Antero)
- Khaw K.-T. (Kay-Tee)
- Khaw K.T.
- Kim Y-J. (Yong-Jin)
- Kim Y.J.
- Kivimaki M. (Mika)
- Kizer J.R. (Jorge)
- Klopp N. (Norman)
- Klopp N. (Norman)
- Kloppenburg M. (Margreet)
- Knight B. (Beatrice)
- Kong A. (Augustine)
- Kong A. (Augustine)
- Kooner J. (Jaspal)
- Koseki M. (Masahiro)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Kristiansson K. (Kati)
- Kronenberg F. (Florian)
- Kronenberg F. (Florian)
- Kumari M. (Meena)
- Kuusisto J. (Johanna)
- Kuzawa C.W. (Christopher W.)
- Kuzawa C.W. (Christopher)
- Kyvik K.O. (Kirsten O.)
- Kyvik K.O. (Kirsten Ohm)
- KÀhönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laakso M. (Markku)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Ladouceur M. (Martin)
- Lajunen T. (Taina)
- Lakatta E.G. (Edward G.)
- Lamina C. (Claudia)
- Lamina C. (Claudia)
- Lange L.A. (Leslie)
- Lange L.A. (Leslie)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Lathrop G. (GMark)
- Launer L.J. (Lenore J.)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lecoeur C. (CĂ©cile)
- Lee J.-Y. (Jong-Young)
- LehtimÀki T. (Terho)
- Lettre G. (Guillaume)
- Li M. (Man)
- Li M. (Man)
- Li X. (Xiaohui)
- Li X. (Xiaohui)
- Li Y. (Yun)
- Lieverse A.G. (Aloysius)
- Lindgren C.M. (Cecilia M.)
- Lindgren C.M. (Cecilia)
- Liu C.-T. (Ching-Ti)
- Liu Y. (YongMei)
- Lohman K. (Kurt)
- Lokki M.L.
- Loo B.-M. (Britt-Marie)
- Loos R.J.F. (Ruth)
- Loos R.J.F. (Ruth)
- Loos R.J.F. (Ruth)
- Luan J. (Jianâan)
- Luan J. (Jianâan)
- Luben R.N. (Robert)
- Lucas G. (Gavin)
- Lyssenko V. (Valeriya)
- Lyssenko V. (Valeriya)
- LyytikÀinen L.-P. (Leo-Pekka)
- MAGIC Consortium
- Magnusson P.K. (Patrik)
- Magnusson P.K.E. (Patrik K. E.)
- Mahley R. (Robert)
- Mangino M. (Massimo)
- Mangino M. (Massimo)
- Manning A.K. (Alisa K.)
- Manning A.K. (Alisa)
- Marmot M. (Michael)
- Marre M. (Michel)
- Marroni F. (Fabio)
- Martin N.G. (Nicholas)
- Martinez-Larrad M.T. (Maria Teresa)
- Masson D. (David)
- McArdle W.L. (Wendy)
- McAteer J.B. (Jarred)
- McCarroll S.A. (Steve)
- McCarroll S.A. (Steven)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura J.)
- McCulloch L.J. (Laura)
- McPherson R. (Ruth)
- Meigs J.B. (James B.)
- Meigs J.B. (James)
- Meigs J.B. (James)
- Meisinger C. (Christa)
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Melander O. (Olle)
- Melzer D. (David)
- Meneton P. (Pierre)
- Meulenbelt I. (Ingrid)
- Meyre D. (David)
- Midthjell K. (Kristian)
- Mitchell B.D. (Braxton)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen)
- Mooser V. (Vincent)
- Mooser V. (Vincent)
- Mooser V.E. (Vincent E.)
- Morken M.A. (Mario A.)
- Morken M.A. (Mario)
- Morris A.D. (Andrew D.)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew P.)
- Morris A.P. (Andrew P.)
- Morris A.P. (Andrew)
- Mukherjee S. (Sutapa)
- Munroe P. (Patricia)
- Musani S. (Solomon)
- Musunuru K. (Kiran)
- MuTHER Consortium
- MĂ€gi R. (Reedik)
- Naitza S. (Silvia)
- Narisu N. (Narisu)
- Narisu N. (Narisu)
- Nathan D.M. (David)
- Navarro P. (Pau)
- Navarro P. (Pau)
- Neville M.J. (Matthew)
- Nickerson D.A. (Deborah A.)
- Nickerson D.A. (Deborah)
- Nieminen M.S. (Markku)
- Nilsson P. (Peter)
- Nuotio M.-L. (Marja-Liisa)
- Oostra B.A. (Ben A.)
- Oostra B.A. (Ben)
- Oostra B.A. (Ben)
- Ordovas J.M. (Jose M.)
- Ordovas J.M. (Jose)
- Orho-Melander M. (Marju)
- OrrĂč M. (Marco)
- Owen K.R. (Katharine)
- OâConnell J. (Jeffrey)
- Pakyz R. (Ruth)
- Palmer C. (Cameron)
- Palmer C.N.A. (Colin N. A.)
- Palmer C.N.A. (Colin)
- Pankow J.S. (James S.)
- Pankow J.S. (James)
- Paolisso G. (Giuseppe)
- Pare G. (Guillame)
- Park T. (Taesung)
- Parker A.N. (Alex)
- Pattaro C. (Cristian)
- Pattaro C. (Cristian)
- Pattou F. (François)
- Paulweber B. (Bernhard)
- Payne F. (Felicity)
- Payne F. (Felicity)
- Pearson D. (Daniel)
- Peden J. (John)
- Pedersen N.L. (Nancy)
- Pedersen O. (Oluf)
- Pedersen O. (Oluf)
- Peloso G.M. (Gina)
- Peltonen L. (Leena Johanna)
- Penninx B.W.J.H.
- Penninx B.W.J.H. (Brenda W. J. H.)
- Penninx B.W.J.H. (Brenda)
- Perola M. (Markus)
- Perola M. (Markus)
- Perola M. (Markus)
- Perry J.R.B. (John R. B.)
- Perry J.R.B. (John R. B.)
- Perry J.R.B. (John)
- Petersen A.K.
- Pfeiffer A.F.H. (Andreas)
- Pichler I. (Irene)
- Pichler I. (Irene)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Posthuma D. (Danielle)
- Potter S.C. (Simon)
- Pouta A. (Anneli)
- Pramstaller P.P. (Peter P.)
- Pramstaller P.P. (Peter P.)
- Pramstaller P.P. (Peter Paul)
- Pramstaller P.P. (Peter Paul)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Province M.A. (Mike)
- Psaty B.M. (Bruce M.)
- Psaty B.M. (Bruce)
- Qi L. (Lu)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quertermous T. (Thomas)
- Rader D.J. (Daniel)
- Raitakari O. (Olli)
- Randall J.C. (Joshua)
- Rasmussen-Torvik L.J. (Laura)
- Rathmann W. (Wolfgang)
- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (Nigel W.)
- Rayner N.W. (Nigel William)
- Redline S. (Susan)
- Reilly M.P. (Muredach P.)
- Rice K.M. (Kenneth)
- Richards J.B. (J. Brent)
- Ricketts S.L. (Sally)
- Ridker P.M. (Paul)
- Rieder M. (Mark)
- Rieder M. (Mark)
- Ripatti S. (Samuli)
- Ripatti S. (Samuli)
- Rivadeneira Ramirez F. (Fernando)
- Roberts R. (Robert)
- Robertson N.R. (Neil)
- Roccasecca R.M.
- Rocheleau G. (Ghislain)
- Rocheleau G. (Ghislain)
- Roden M. (Michael)
- Roden M. (Michael)
- Rolandsson O. (Olov)
- Rose L.M. (Lynda)
- Rotter J.I. (Jerome I)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Ruokonen A. (Aimo)
- Ruokonen A. (Aimo)
- Rybin D. (Denis)
- Sabatti C. (Chiara)
- Saharinen J. (Juha)
- Salomaa V. (Veikko)
- Salomaa V. (Veikko)
- Salomaa V. (Veikko)
- Samani N.J. (Nilesh)
- Samani N.J. (Nilesh)
- Sampson M.J. (Michael J)
- Sampson M.J. (Michael)
- Sandbaek A. (Annelli)
- Sandhu M. (Manjinder)
- Sandhu M.S. (Manjinder)
- Sanna S. (Serena)
- Sanna S. (Serena)
- Sattar N. (Naveed)
- Saxena R. (Richa)
- Saxena R. (Richa)
- Sayer A.A.
- Schadt E.E. (Eric E.)
- Schadt E.E. (Eric)
- Scheet P. (Paul)
- Schlessinger D. (David)
- Schlessinger D. (David)
- Schunkert H. (Heribert)
- Schwarz P.E.H. (Peter)
- Scott L.J. (Laura J.)
- Scott L.J. (Laura)
- Scott R.A. (Robert)
- Scuteri A. (Angelo)
- Scuteri A. (Angelo)
- Scuteri A. (Angelo)
- Seedorf U. (Udo)
- SegrĂš A.V. (Ayellet)
- Seielstad M. (Mark)
- Semple R.K. (Robert K.)
- Serrano-RĂos M. (Manuel)
- Sethupathy P. (Praveen)
- Sharp S.J. (Stephen)
- Shields B.M. (Beverley)
- Shields B.M. (Beverley)
- Shrader P. (Peter)
- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
- Sigurdsson G. (Gunnar)
- Sigursson G. (Gunnar)
- Sijbrands E. (Eric)
- Sijbrands E.J.G. (Eric J. G.)
- Sijbrands E.J.G. (Eric)
- Silander K. (Kaisa)
- Silander K. (Kaisa)
- Silveira A. (Angela)
- Sim X. (Xueling)
- Sim X. (Xueling)
- Simpson L. (Laila)
- Singleton A. (Andrew)
- Sinisalo J. (Juha)
- Siscovick D.S. (David)
- Siscovick D.S. (David)
- Sladek R. (Rob)
- Sladek R. (Rob)
- Slagboom P.E. (Eline)
- Small K.S. (Kerrin)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith A.V. (Davey)
- Smith G.D. (George Davey)
- Smith J.D. (Joshua D.)
- Smith N.L. (Nicholas)
- Song K. (Kijoung)
- Soranzo N. (Nicole)
- Soranzo N. (Nicole)
- Sovio U. (Ulla)
- SparsĂž T. (Thomas)
- SparsĂž T. (Thomas)
- Spector T.D. (Tim D.)
- Spector T.D. (Timothy D.)
- Spector T.D. (Timothy)
- Spranger J. (Joachim)
- St Pourcain B. (Beate)
- Stefansson K. (Kari)
- Stefansson K. (Kari)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Steinthorsdottir V. (Valgerdur)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Stringham H.M. (Heather M.)
- Stringham H.M. (Heather M.)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Stylianou I.M. (Ioannis M.)
- Stylianou I.M. (Ioannis)
- Sun Q. (Qi)
- Surakka I. (Ida)
- Swift A.J. (Amy)
- Swift A.J. (Amy)
- Syddall H. (Holly)
- SyvÀnen A.C.
- Tai E.-S. (E-Shyong)
- Tai E.S. (Shyong)
- Tall A.R. (Alan R.)
- Tanaka T. (Toshiko)
- Taylor H.A. (Herman A.)
- Taylor H.A. (Herman)
- Teslovich T.M. (Tanya M.)
- Teslovich T.M. (Tanya M.)
- Thompson J.R. (John)
- Thompson J.R. (John)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas J.)
- Timpson N.J. (Nicholas)
- Tracy R.P. (Russell)
- Tuomi T. (Tiinamaija)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Tuomilehto J. (Jaakko)
- Tuomilehto J. (Jaakko)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uda M. (Manuela)
- Uh H.-W. (Hae-Won)
- Uitterlinden A. (Andre)
- Uitterlinden A.G. (Andre G.)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- van Duijn C. (Cornelia)
- van Duijn C.M. (Cornelia M.)
- van Duijn C.M. (Cornelia M.)
- van Hoek M. (Mandy)
- Varma D. (Dhiraj)
- Viikari J. (Jorma)
- Visvikis-Siest S. (Sophie)
- Vitart V. (Veronique)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Vogelzangs N. (Nicole)
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin)
- Vollenweider P. (Peter)
- Vollenweider P. (Peter)
- Vollenweider P. (Peter)
- Waeber G. (GĂ©rard)
- Waeber G. (GĂ©rard)
- Wagner P.J. (Peter)
- Walker M. (Mark)
- Walley A. (Andrew)
- Walters G. (GBragi)
- Walters G.B. (Bragi)
- Ward K.L. (Kim L.)
- Wareham N.J. (Nick J.)
- Wareham N.J. (Nick)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard M.)
- Watanabe R.M. (Richard)
- Waterworth D. (Dawn)
- Waterworth D. (Dawn)
- Waterworth D.M. (Dawn)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R.P. (Ryan)
- Wheeler E. (Eleanor)
- Whitfield J. (John)
- Wichmann H.-E. (H.-Erich)
- Wichmann H.E. (H. Erich)
- Wichmann H.E. (Heinz Erich)
- Wichmann H.E. (Heinz Erich)
- Wijmenga C. (Cisca)
- Wild S.H. (Sarah)
- Willems van Dijk J.A.P. (Ko)
- Willems S.M. (Sara)
- Willems-vanDijk K. (Ko)
- Willemsen G.
- Willemsen G.A.H.M. (Gonneke)
- Willer C.J. (Cristen J.)
- Willer C.J. (Cristen)
- Williams G.H. (Gordon)
- Wilson J.F. (James F.)
- Wilson J.F. (James)
- Wilson J.G. (James G.)
- Winkler T.W. (Thomas W.)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline C. M.)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C. M.)
- Wong T.Y. (Tien Y.)
- Wood A.R. (Andrew)
- Wright A.F. (Alan)
- Wright A.F. (Alan)
- Wu G. (Guanming)
- Wu Y. (Ying)
- Yarnell J.W.G. (John W.)
- Yuan X. (Xin)
- Zabena C. (Carina)
- Zee R.Y.L. (Robert)
- Zeggini E. (Eleftheria)
- Zeggini E. (Eleftheria)
- Zelenika D. (Diana)
- Zethelius B. (Björn)
- Zhai G. (Guangju)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Zhao J.H. (Jing Hua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zwart J-A. (John-Anker)
- Ădonnell C.J. (Christopher)
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5Ă10â8- 1.2 Ă10â43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3Ă10â4). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3Ă10â3, n = 22,044), increased triglycerides (p = 2.6Ă10â14, n = 93,440), increased waist-to-hip ratio (p = 1.8Ă10â5, n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4Ă10â3, n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL- cholesterol concentrations (p = 4.5Ă10â13, n = 96,748) and decreased BMI (p = 1.4Ă10â4, n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance