The Selection and Implementation of a Drug and Alcohol Intervention Program/Model for Grand Coulee Dam Junior High School, Grand Coulee, Washington

The purpose of this study was to plan and implement an intervention program to combat adolescent substance abuse at Grand Coulee Dam Junior High School, Grand Coulee, Washington. This study presented a review of the research and literature related to drug and alcohol intervention models and has documented the steps and procedures taken by the Grand Coulee Dam Junior High School Core Team to implement the intervention model selected

Estimating The Costs And Cost-effectiveness Of Promoting Mammography Screening Among US-based Latinas

Purpose: We characterize the costs and cost-effectiveness of a community health worker (CHW)-based intervention to promote screening mammography among US-based non-adherent Latinas. Methods: The parent study was a randomized controlled trial for 536 Latinas aged 42-74 years old who had sought care within a safety net health center in Western Washington. Participants were block-randomized within clinic to the control arm (usual care) or intervention arm (CHW-led motivational interviewing intervention). We used the perspective of the organization implementing promotional activities to characterize costs and cost-effectiveness. Cost data were categorized as program set-up and maintenance (initial training, booster/annual training) program implementation (administrative activities, intervention delivery); and, overhead/miscellaneous expenses. Cost-effectiveness was calculated as the incremental cost of screening for each additional woman screened between the intervention and control arms. Results: The respective costs per participant for standard care and the intervention arm were $69.96 and$300.99. There were no study arm differences in 1-year QALYs among women who completed a 12-month follow-up survey (intervention= 0.8827, standard care = 0.8841). Most costs pertained to program implementation and administrative activities specifically. The incremental cost per additional woman screened was $2,595.32. Conclusions: Our findings are within the ranges of costs and cost-effectiveness for other CHW programs to promote screening mammography among underserved populations. Our strong study design and focus on non-adherent women provides important strengths to this body of work, especially give implementation and dissemination science efforts regarding CHW-based health promotion for health disparity populations

A near infrared frequency comb for Y+J band astronomical spectroscopy

Radial velocity (RV) surveys supported by high precision wavelength references (notably ThAr lamps and I2 cells) have successfully identified hundreds of exoplanets; however, as the search for exoplanets moves to cooler, lower mass stars, the optimum wave band for observation for these objects moves into the near infrared (NIR) and new wavelength standards are required. To address this need we are following up our successful deployment of an H band(1.45-1.7{\mu}m) laser frequency comb based wavelength reference with a comb working in the Y and J bands (0.98-1.3{\mu}m). This comb will be optimized for use with a 50,000 resolution NIR spectrograph such as the Penn State Habitable Zone Planet Finder. We present design and performance details of the current Y+J band comb.Comment: Submitted to SPIE, conference proceedings 845

Development of a Semi-Field System for Contained Field Trials With Aedes Aegypti in Southern Mexico

Development of new genetic approaches to either interfere with the ability of mosquitoes to transmit dengue virus or to reduce vector population density requires progressive evaluation from the laboratory to contained field trials, before open field release. Trials in contained outdoor facilities are an important part of this process because they can be used to evaluate the effectiveness and reliability of modified strains in settings that include natural environmental variations without releasing mosquitoes into the open field. We describe a simple and cost-effective semi-field system designed to study Aedes aegypti carrying a dominant lethal gene (fsRIDL) in semi-field conditions. We provide a protocol for establishing, maintaining, and monitoring stable Ae. aegypti population densities inside field cages

Near field modal noise reduction using annealed optical fiber

Incomplete and unstable mode population has long complicated the application of optical fiber for transferring star and calibration light to high precision spectrographs. The need for improved precision calibrators in support of radial velocity planet surveys has led to the introduction of coherent wavelengths sources using single mode fibers that are then coupled into multi-mode fibers, further exacerbating this problem. We explore mode scrambling in annealed optical fiber with and without agitation, as compared to that obtained using octagonal fiber and using an integrating sphere. We observe improved scrambling with annealed fibers compared to conventional and octagonal fibers

A High-Resolution Atlas of Uranium-Neon in the H Band

We present a high-resolution (R ~ 50 000) atlas of a uranium-neon (U/Ne) hollow-cathode spectrum in the H-band (1454 nm to 1638 nm) for the calibration of near-infrared spectrographs. We obtained this U/Ne spectrum simultaneously with a laser-frequency comb spectrum, which we used to provide a first-order calibration to the U/Ne spectrum. We then calibrated the U/Ne spectrum using the recently-published uranium line list of Redman et al. (2011), which is derived from high-resolution Fourier transform spectrometer measurements. These two independent calibrations allowed us to easily identify emission lines in the hollow cathode lamp that do not correspond to known (classified) lines of either uranium or neon, and to compare the achievable precision of each source. Our frequency comb precision was limited by modal noise and detector effects, while the U/Ne precision was limited primarily by the signal-to-noise ratio (S/N) of the observed emission lines and our ability to model blended lines. The standard deviation in the dispersion solution residuals from the S/N-limited U/Ne hollow cathode lamp were 50% larger than the standard deviation of the dispersion solution residuals from the modal-noise-limited laser frequency comb. We advocate the use of U/Ne lamps for precision calibration of near-infrared spectrographs, and this H-band atlas makes these lamps significantly easier to use for wavelength calibration.Comment: 23 pages, 7 figures, submitted and accepted in ApJSS. Online-only material to be published online by ApJS

Comparison of Chlamydia antigen and AD-like pathology in the brains of BALB/c mice following intranasal infection with Chlamydia muridarum or Chlamydia pneumoniae

Previous research indicates BALB/c mice inoculated with Chlamydia pneumoniae (Cpn) demonstrated AD-like pathology which suggests that this mouse model is valid for studying the pathogenesis implicated in Alzheimer’s disease (AD). Studies have demonstrated that Chlamydia trachomatis (Ctr) can disseminate from its primary site of infection and plays a major role in the induction of reactive arthritis. The objectives of this lab are: (1) to identify and localize Chlamydia antigens in the brains of BALB/c mice infected with C. muridarum and (2) to determine if infection with C. muridarum induces AD-like pathology comparable to Cpn. Using mouse adapted respiratory isolates of C. muridarum, we investigated whether C. muridarum disseminated from the respiratory tract to the brain. Mice were intranasally infected with plaqued C small Weiss (CSW) or plaqued mouse pneumonitis Weiss (MoPn Weiss). Brain tissue was isolated at 2 months post-infection. Serial sections from brains infected mice were analyzed for amyloid or Chlamydia antigens. Preliminary analysis of brain tissue demonstrated no detectable difference in C. muridarum antigen between mice receiving 1 x105 IFU and mice receiving 1 x101 IFU, whereas a small but detectable difference was identified in amyloid-specific labeling between these two experimental groups. In contrast, prominent Chlamydia-specific labeling was identified in the brains of Cpn-infected mice as well as substantial amyloid deposition at 2 months p.i.. These data suggest that, relative to Cpn AR-39 infection, C. muridarum infection is a weaker stimulus for inflammation, resulting in decreased amyloid deposition in the brains of BALB/c mice