452 research outputs found
Observation of fine one-dimensionally disordered layers in silicon carbide
The improved resolution of synchrotron edge-topography is enabling thinner (less than 100 microns), silicon carbide crystals to be studied, and is providing a more detailed and wider database on polytype depth profiles. Fine long-period and one-dimensionally-disordered layers, 5-25 microns thick, can now be confidently resolved and are found to be very common features, often in association with high-defect density bands. These features are illustrated in this paper using three examples. A new long period polytype LPP (152H/456R) has been discovered and reported here for the first time
Raman spectroscopy of epitaxial graphene on a SiC substrate
The fabrication of epitaxial graphene (EG) on SiC substrate by annealing has
attracted a lot of interest as it may speed up the application of graphene for
future electronic devices. The interaction of EG and the SiC substrate is
critical to its electronic and physical properties. In this work, Raman
spectroscopy was used to study the structure of EG and its interaction with SiC
substrate. All the Raman bands of EG blue shift from that of bulk graphite and
graphene made by micromechanical cleavage, which was attributed to the
compressive strain induced by the substrate. A model containing 13 x 13
honeycomb lattice cells of graphene on carbon nanomesh was constructed to
explain the origin of strain. The lattice mismatch between graphene layer and
substrate causes the compressive stress of 2.27 GPa on graphene. We also
demonstrate that the electronic structures of EG grown on Si and C terminated
SiC substrates are quite different. Our experimental results shed light on the
interaction between graphene and SiC substrate that are critical to the future
applications of EG.Comment: 20 pages, 5 figure
Liver genomic responses to ciguatoxin: evidence for activation of Phase I and Phase II detoxification pathways following an acute hypothermic response in mice
Ciguatoxins (CTX) are polyether neurotoxins that target voltage-gated sodium channels and are responsible for ciguatera, the most common fish-borne food poisoning in humans. This study characterizes the global transcriptional response of mouse liver to a symptomatic dose (0.26 ng/g) of the highly potent Pacific ciguatoxin-1 (P-CTX-1). At 1 h post-exposure 2.4% of features on a 44K whole genome array were differentially expressed (p ≤ 0.0001), increasing to 5.2% at 4 h and decreasing to 1.4% by 24 h post-CTX exposure. Data were filtered (|fold change| ≥ 1.5 and p ≤ 0.0001 in at least one time point) and a trend set of 1550 genes were used for further analysis. Early gene expression was likely influenced prominently by an acute 4°C decline in core body temperature by 1 h, which resolved by 8 h following exposure. An initial downregulation of 32 different solute carriers, many involved in sodium transport, was observed. Differential gene expression in pathways involving eicosanoid biosynthesis and cholesterol homeostasis was also noted. Cytochrome P450s (Cyps) were of particular interest due to their role in xenobiotic metabolism. Twenty-seven genes, mostly members of Cyp2 and Cyp4 families, showed significant changes in expression. Many Cyps underwent an initial downregulation at 1 h but were quickly and strongly upregulated at 4 and 24 h post-exposure. In addition to Cyps, increases in several glutathione S-transferases were observed, an indication that both phase I and phase II metabolic reactions are involved in the hepatic response to CTX in mice
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