16 research outputs found
SDLFormer: A Sparse and Dense Locality-enhanced Transformer for Accelerated MR Image Reconstruction
Transformers have emerged as viable alternatives to convolutional neural
networks owing to their ability to learn non-local region relationships in the
spatial domain. The self-attention mechanism of the transformer enables
transformers to capture long-range dependencies in the images, which might be
desirable for accelerated MRI image reconstruction as the effect of
undersampling is non-local in the image domain. Despite its computational
efficiency, the window-based transformers suffer from restricted receptive
fields as the dependencies are limited to within the scope of the image
windows. We propose a window-based transformer network that integrates dilated
attention mechanism and convolution for accelerated MRI image reconstruction.
The proposed network consists of dilated and dense neighborhood attention
transformers to enhance the distant neighborhood pixel relationship and
introduce depth-wise convolutions within the transformer module to learn
low-level translation invariant features for accelerated MRI image
reconstruction. The proposed model is trained in a self-supervised manner. We
perform extensive experiments for multi-coil MRI acceleration for coronal PD,
coronal PDFS and axial T2 contrasts with 4x and 5x under-sampling in
self-supervised learning based on k-space splitting. We compare our method
against other reconstruction architectures and the parallel domain
self-supervised learning baseline. Results show that the proposed model
exhibits improvement margins of (i) around 1.40 dB in PSNR and around 0.028 in
SSIM on average over other architectures (ii) around 1.44 dB in PSNR and around
0.029 in SSIM over parallel domain self-supervised learning. The code is
available at https://github.com/rahul-gs-16/sdlformer.gitComment: Accepted at MICCAI workshop MILLanD 2023 Medical Image Learning with
noisy and Limited Dat
Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance
10.1186/s13073-015-0219-2Genome Medicine719
High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer
10.1186/s13059-015-0589-1Genome Biology1613
CD44-SLC1A2 gene fusions in gastric cancer
10.1126/scitranslmed.3001423Science Translational Medicine377
Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck
10.1038/srep19552Scientific Reports61955
Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer
10.1016/j.ccell.2017.11.018Cancer Cell331137-150 e5CCAE
Exogenous MAL Reroutes Selected Hepatic Apical Proteins into the Direct Pathway in WIF-B Cells
Unlike simple epithelial cells that directly target newly synthesized glycophosphatidylinositol (GPI)-anchored and single transmembrane domain (TMD) proteins from the trans-Golgi network to the apical membrane, hepatocytes use an indirect pathway: proteins are delivered to the basolateral domain and then selectively internalized and transcytosed to the apical plasma membrane. Myelin and lymphocyte protein (MAL) and MAL2 have been identified as regulators of direct and indirect apical delivery, respectively. Hepatocytes lack endogenous MAL consistent with the absence of direct apical targeting. Does MAL expression reroute hepatic apical residents into the direct pathway? We found that MAL expression in WIF-B cells induced the formation of cholesterol and glycosphingolipid-enriched Golgi domains that contained GPI-anchored and single TMD apical proteins; polymeric IgA receptor (pIgA-R), polytopic apical, and basolateral resident distributions were excluded. Basolateral delivery of newly synthesized apical residents was decreased in MAL-expressing cells concomitant with increased apical delivery; pIgA-R and basolateral resident delivery was unchanged. These data suggest that MAL rerouted selected hepatic apical proteins into the direct pathway