Intelligence and Autonomy in the Sat4EO+ Satellite

The responsiveness of an Earth observation (EO) service, in terms of the time from the initiation of satellite tasking after an End User request is accepted, until the availability of the Earth Observation product to the End User, is a key metric in many applications, such as security, disaster monitoring and nowcasting, and more generally in enhanced-NRT services. Elecnor DEIMOS is currently developing its next proprietary Very-High Resolution (VHR) small satellite [1][2], Sat4EO+, to meet current and upcoming market needs for Earth Observation products derived from a sub-meter optical imaging capability. Sat4EO+ is an agile low-cost ~200kg VNIR optical satellite, providing ~50cm native VHR imaging. In Sat4EO+, responsiveness has been included as a key performance parameter, with a requirement that the Sat4EO+ service shall provide responsiveness down to 10 minutes, globally, for high-priority products. This poster describes the approach employed by DEIMOS to achieve this responsiveness requirement below 10 minutes globally in the Sat4EO+ satellite. The responsive service is based on several key capabilities for small satellites, which, when employed in combination, lead to an intelligent satellite, with increased autonomy, that provides for an innovative service to the End User. These capabilities are: rapid global tasking, exploiting a permanent communications link to the Sat4EO+ satellite through a global high-rate geo-relay link; re-configurable data handling on-board the satellite, to manage both high and standard priority products and their transfer to the End User; on-board processing, through DEIMOS\u27 propriety Insight4EO HW/SW turnkey product embedding Artificial Intelligence (AI) and Machine Learning (ML) algorithms, allowing for the generation of high-priority Earth observation products on-board the satellite and their direct transfer to the End User globally with very low latency (real-time), exploiting the global communications link and the relative small size of such products; autonomous task management on-board the satellite, to manage autonomously high and standard priority tasks, and perform tasks such as data prioritisation, thus maximising the overall duty cycle of the satellite and the service performance and ROI

Calidad de servicio y satisfacción del cliente del instituto de desarrollo y capacitación de la ciudad de Trujillo

En la presente investigación: Calidad de servicio y satisfacción del cliente del Instituto de Desarrollo y Capacitación-Trujillo se formuló como problema ¿Cuál es la relación que existe entre la calidad de servicio y la satisfacción del cliente del Instituto de Desarrollo y Capacitación - Trujillo? se planteó además el objetivo general que es determinar la relación que existe entre calidad de servicio y la satisfacción de los clientes del Instituto de Desarrollo y Capacitación - Trujillo. Se utilizó la metodología tipo aplicada, con diseño correlacional – no experimental. Se empleó como herramienta un cuestionario, el cual fue aplicado a 142 estudiantes matriculados en Trujillo. El resultado fue que el 45,8% manifestaron un nivel bajo de calidad de servicio; el 46,5% manifestaron un nivel bajo de satisfacción del cliente y se definió que consta una relación significativa y directa entre la calidad de la prestación y el agrado del usuario. La presente investigación concluyó que existe relación altamente significativa, con un coeficiente de correlación de Spearman de 0.615.Tesi

Diversity of human rotaviruses detected in Sicily, Italy, over a 5-years period (2001-2005).

It is well known that the death of dopaminergic neurons of the substantia nigra pars compacta (SNc) is the pathological hallmark of Parkinson's disease (PD), the second most common and disabling condition in the expanding elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and, consequently, treatment is largely symptomatic rather than preventive. Moreover, the mechanisms whereby nigral dopaminergic neurons may degenerate still remain controversial. Hitherto, several data have shown that the earlier cellular disturbances occurring in dopaminergic neurons include oxidative stress, excitotoxicity, inflammation, mitochondrial dysfunction and altered proteolysis. These alterations, rather than killing neurons, trigger subsequent death-related molecular pathways, including elements of apoptosis. In rare incidences, PD may be inherited; this evidence has opened a new and exciting area of research, attempting to shed light on the nature of the more common idiopathic PD form. In this review, the characteristics of the SNc dopaminergic neurons and their lifecycle from birth to death are reviewed. In addition, of the mechanisms by which the aforementioned alterations cause neuronal dopaminergic death, particular emphasis will be given to the role played by inflammation, and the relevance of the possible use of anti-inflammatory drugs in the treatment of PD. Finally, new evidence of a possible de novo neurogenesis in the SNc of adult animals and in PD patients will also be examined

Expert clinical pharmacological advice may make an antimicrobial TDM program for emerging candidates more clinically useful in tailoring therapy of critically ill patients

Background Therapeutic drug monitoring (TDM) may represent an invaluable tool for optimizing antimicrobial therapy in septic patients, but extensive use is burdened by barriers. The aim of this study was to assess the impact of a newly established expert clinical pharmacological advice (ECPA) program in improving the clinical usefulness of an already existing TDM program for emerging candidates in tailoring antimicrobial therapy among critically ill patients. Methods This retrospective observational study included an organizational phase (OP) and an assessment phase (AP). During the OP (January-June 2021), specific actions were organized by MD clinical pharmacologists together with bioanalytical experts, clinical engineers, and ICU clinicians. During the AP (July-December 2021), the impact of these actions in optimizing antimicrobial treatment of the critically ill patients was assessed. Four indicators of performance of the TDM-guided real-time ECPA program were identified [total TDM-guided ECPAs July-December 2021/total TDM results July-December 2020; total ECPA dosing adjustments/total delivered ECPAs both at first assessment and overall; and turnaround time (TAT) of ECPAs, defined as optimal (< 12 h), quasi-optimal (12-24 h), acceptable (24-48 h), suboptimal (> 48 h)]. Results The OP allowed to implement new organizational procedures, to create a dedicated pathway in the intranet system, to offer educational webinars on clinical pharmacology of antimicrobials, and to establish a multidisciplinary team at the morning bedside ICU meeting. In the AP, a total of 640 ECPAs were provided for optimizing 261 courses of antimicrobial therapy in 166 critically ill patients. ECPAs concerned mainly piperacillin-tazobactam (41.8%) and meropenem (24.9%), and also other antimicrobials had >= 10 ECPAs (ceftazidime, ciprofloxacin, fluconazole, ganciclovir, levofloxacin, and linezolid). Overall, the pre-post-increase in TDM activity was of 13.3-fold. TDM-guided dosing adjustments were recommended at first assessment in 61.7% of ECPAs (10.7% increases and 51.0% decreases), and overall in 45.0% of ECPAs (10.0% increases and 35.0% decreases). The overall median TAT was optimal (7.7 h) and that of each single agent was always optimal or quasi-optimal. Conclusions Multidisciplinary approach and timely expert interpretation of TDM results by MD Clinical Pharmacologists could represent cornerstones in improving the cost-effectiveness of an antimicrobial TDM program for emerging TDM candidates

PS447 Environmental Politics & Policy Zoom Presentations - Session #2

Over the spring quarter 2021, students from PS447 Environmental Politics and Policy have been researching a substantial environmental issue of their choice, defining a problem found within the issue, and devising and implementing an awareness campaign focused on a solution to the problem. During the Academic Excellence Showcase zoom presentation they will be presenting their environmental issue, creating awareness and proposing a solution for the audience. Students will present on a wide range of environmental themes such plastic waste, air pollution, deforestation and climate change

¿El derecho ambiental es una necesidad en la sociedad actual?

Uno de los propósitos del ser humano que se puede manifestar en la prevalencia de su ambiente y su prójimo; la investigación propuesta a continuación brindara los conceptos necesarios para argumentar y esclarecer el tema y la pregunta la cual radica en el derecho Ambiental y ¿cómo es necesario en la sociedad? A continuación, se determinara el primer término el cual es el Derecho Ambiental; que está compuesto por normas que regulan las actividades de los seres humanos para obtener una protección y prevención con el ambiente, esto abarca (Lo que lo rodea) o el entorno donde vivimos, desde el primer momento se mencionó que el derecho ambiental iniciaba desde la ciencia informativa que para su mejor comprensión es. El análisis en se usa los términos asociados para obtener y clasificar lo que y lo que no es; en donde, todo dependerá de la perspectiva que se encuentre el orden, el conocimiento y la información

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN