Coupling of mixed layer processes and thermocline variations in the Arabian Sea

This study presents an analysis of observed data sets from multiple sources, including observations from a network of Argo floats during (2002–2003), with the aim of investigating the role of the southwest monsoon circulation in affecting the interactions between the oceanic mixed layer and the underlying thermocline in the northern Indian Ocean. Examination of the seasonal cycle of the upper-ocean thermal structure shows that the surface cooling of the Arabian Sea, during the southwest monsoon season, is accompanied by significant warming of the thermocline. It is seen that the thermocline is warmer by about 1.2°C in the south-central Arabian Sea during the southwest monsoon season relative to other months. Offline computations of the profiles of vertical diffusivity of heat reveal stronger and deeper penetration of heat into the Arabian Sea during the southwest monsoon season. The results presented in the paper demonstrate that the combined effects of strong wind-driven mixing by the monsoonal winds, weak density stratification in the upper-ocean, and downwelling in south-central Arabian Sea, along with strong vertical diffusivity, favor downward transfer of warm waters from the surface into the thermocline. Besides the climatological seasonal cycle, the present study also examines the impact of monsoon interannual variability on the upper-ocean response, by analysis of long-term observed records during (1955–2001) as well as the Argo observations for (2002–2003). It is found that the interannual variations in the ocean response reveal signatures of the influence of strong and weak southwest monsoons on the mixed layer and thermocline variabilities

Management outcomes in pubic diastasis: our experience with 19 patients

<p>Abstract</p> <p>Background</p> <p>Pubic diastasis, a result of high energy antero-posterior compression (APC) injury, has been managed based on the Young and Burguess classification system. The mode of fixation in APC II injury has, however, been a subject of controversy and some authors have proposed a need to address the issue of partial breach of the posterior pelvic ring elements in these injuries.</p> <p>Methods</p> <p>The study included a total of 19 patients with pubic diastasis managed by us from May 2006 to December 2007. There was a single patient with type I APC injury who treated conservatively. Type II APC injuries (13 patients) were treated surgically with symphyseal plating using single anterior/superior plates or double perpendicularly placed plates. Type III injuries (5 patients) in addition underwent posterior fixation using plates or percutaneous sacro-iliac screws. The outcome was assessed clinically (Majeed score) and radiologically.</p> <p>Results</p> <p>The mean follow-up was for 2.9 years (6 months to 4.5 years). Among the 13 patients with APC II injuries, the clinical scores were excellent in one (7.6%), good in 6 (46.15%), fair in 4 (30.76%) and poor in 2 (15.38%). Radiological scores were excellent in 2 (15.38%), good in 8 (61.53%), fair in 2 (15.38%) and poor in one patient (7.6%). Among the 5 patients with APC III injuries, there were 2 patients each with good (50%) and fair (50%) clinical scores while one patient was lost on long term follow up. The radiological outcomes were also similar in these. Complications included implant failure in 3 patients, postoperative infection in 2 patients, deep venous thrombosis in one patient and bladder herniation in one of the patients with implant failure.</p> <p>Conclusions</p> <p>There is no observed dissimilarity in outcomes between isolated anterior and combined symphyseal (perpendicular) plating techniques in APC II injuries. Single anterior symphyseal plating along with posterior stabilisation provides a stable fixation in type III APC injuries. Limited dissection ensuring adequate intactness of rectus sheath is important to avoid long term post-operative complications.</p

Sub-synoptic circulation variability in the Himalayan extreme precipitation event during June 2013

This study investigates the sub-synoptic scale circulation aspects associated with the extreme rainfall event occurred over the North Indian state of Uttarakhand located in the western Himalayas (WH) during the 15–18 June 2013 period. A diagnosis based on hourly ERA5 reanalyzed circulation products archived on finer grids reveals that sustenance of heavy rains during the event period is supported by a propensity of cyclonic vorticity sources channeled toward the WH region through a narrow quasi-steady conduit in the lower troposphere from the ISM circulation. The equatorward segregating mesoscale potential vorticity (PV) structures from the quasi-stationary upper level PV anomaly (trough) during the event administered two pathways for vorticity sources. The first pathway is from the base of the trough culminating into longer horizontal conduit path from the western Arabian Sea, lending perpetual cyclonic vorticity support to the ISM environment. The second pathway is from the right flank of the trough, which promotes sustained environment of deeper mesoscale convergence zone, potentially unstable atmosphere and strong ascent over the Uttarakhand region. The convergence zone is potentially viewed as a region for strong monsoon and extratropical circulation interactions to occur on finer horizontal scales of motion, where significant vertical synchronization of positive PV advection is realized during the 16–17 June 2013 period. In addition to orographic precipitation enhancements, deeper advective synchronization noticed at sub-synoptic time periods is accredited to the nearly doubling 24-h rainfall amounts in the foothill region of Uttarakhand during the event period. The ERA5 diagnosed diabatic heating additionally indicates that precipitating systems at higher (foothill) elevations contribute to upper (lower) tropospheric heat sources

Re-examination of the I-5 dust storm

The infamous dust storm over the thanksgiving holiday of 1991 that led to loss of life from numerous automobile accidents on Interstate 5 (I-5) has been re-examined. Pauley et al. (1996) conducted an earlier investigation of this dust storm following the tenets of Danielsen's paradigm—a paradigm that links the tropopause fold phenomenon and a balanced thermally indirect circulation about the upper level jet stream. However, a cursory examination of mesoscale structures in the storm from the North American Regional Reanalysis (NARR) indicated evidence of a low-level unbalanced thermally direct circulation that demanded further investigation using a high-resolution Weather Research and Forecasting (WRF) model simulation. Principal results from the present study follow: (1) Although the model simulation showed evidence of a weak indirect circulation in the upper troposphere in support of the Danielsen's paradigm, the dynamic control of the storm stemmed from the lower tropospheric mesoscale response to geostrophic imbalance. (2) A lower tropospheric direct circulation led to mass/temperature adjustments that were confirmed by upper air observations at locations in proximity to the accident site, and (3) boundary layer deepening and destabilization due to these mesoscale processes pinpointed the timing and location of the dust storm. Although the present study does not underestimate the value of analyses that focus on the larger/synoptic scales of motion, it does bring to light the value of investigation that makes use of the mesoscale resources in order to clarify synoptic-mesoscale interactions

Meridionally Extending Anomalous Wave Train over Asia During Breaks in the Indian Summer Monsoon

Anomalous interactions between the Indian summer monsoon (ISM) circulation and subtropical westerlies are known to trigger breaks in the ISM on subseasonal time-scales, characterised by a pattern of suppressed rainfall over central-north India, and enhanced rainfall over the foothills of the central–eastern Himalayas (CEH). An intriguing feature during ISM breaks is the formation of a mid-tropospheric cyclonic circulation anomaly extending over the subtropical and mid-latitude areas of the Asian continent. This study investigates the mechanism of the aforesaid Asian continental mid-tropospheric cyclonic circulation (ACMCC) anomaly using observations and simplified model experiments. The results of our study indicate that the ACMCC during ISM breaks is part of a larger meridional wave train comprising of alternating anticyclonic and cyclonic anomalies that extend poleward from the monsoon region to the Arctic. A lead–lag analysis of mid-tropospheric circulation anomalies suggests that the meridional wave-train generation is linked to latent heating (LH) anomalies over the CEH foothills, Indo-China, and the Indian landmass during ISM breaks. By conducting sensitivity experiments using a simplified global atmospheric general circulation model forced with satellite-derived three-dimensional LH, it is demonstrated that the combined effects of the enhanced LH over the CEH foothills and Indo-China and decreased LH over the Indian landmass during ISM breaks are pivotal for generating the poleward extending meridional wave train and the ACMCC anomaly. At the same time, the spatial extent of the mid-latitude cyclonic anomaly over Far-East Asia is also influenced by the anomalous LH over central–eastern China. While the present findings provide interesting insights into the role of LH anomalies during ISM breaks on the poleward extending meridional wave train, the ACMCC anomaly is found to have important ramifications on the daily rainfall extremes over the Indo-China region. It is revealed from the present analysis that the frequency of extreme rainfall occurrences over Indo-China shows a twofold increase during ISM break periods as compared to active ISM conditions. © 2019, The Author(s)

Structure and regeneration status of mangrove patches along the estuarine and coastal stretches of Kerala, India

This study presents the structural characteristics and regeneration potential of mangrove patches in the estuarine and coastal areas of Kerala, a tropical maritime state in India. Field surveys were carried out at 46 selected sites during August 2015 to May 2016. In each site, the vegetative structure and regeneration status were assessed using the quadrat method. Altogether 219 quadrates were laid out and a total of 13 true mangrove species, belonging to 5 families and 8 genera, were recorded. The total tree density and stand basal area of the study region was 1678.08/ha and 20.33 m2/ha respectively. The low basal areas indicate the reduced structural development in mangroves. Of the 13 tree species, Avicennia constitutes 56% of the total Important Value Index (IVI) and Avicennia officinalis represents 41% of the IVI in Kerala, followed by Avicennia marina (15%), Rhizophora mucronata (15%), Sonneratia alba (8%) Rhizophora apiculata (7%) and Excoecaria agallocha (7%). The diameter at breast height (DBH) in the study area revealed that 47% of the tree species came under the 1–10 cm DBH class. Total sapling and seedling density in Kerala was 2238.35 and 3232.42 individuals/ha respectively. Density of young plants (seedlings ? saplings) was only 31% greater of tree density and varied from 3–63%, which indicates poor regeneration potential. The Maturity index value (MIV) and complexity index (Ic) value of mangroves were 18.30 and 109.81 respectively. However, the low Ic value (\10) observed in seven out of ten coastal districts indicated poor structural development of mangroves in Kerala. Therefore, locationspecific conservation and management measures, guided by the knowledge on spatial distribution and habitat requirements of mangrove varieties should be taken to preserve the mangrove diversity of Kerala

On an Analytical Model for Long-Range Financial Planning (2)

The inhibitor of the nuclear factor-kappa B (I kappa B) kinase (IKK) complex is a key regulator of the canonical NF-kappa B signalling cascade and is crucial for fundamental cellular functions, including stress and immune responses. The majority of IKK complex functions are attributed to NF-kappa B activation; however, there is increasing evidence for NF-kappa B pathway-independent signalling. Here we combine quantitative mass spectrometry with random forest bioinformatics to dissect the TNF-alpha-IKK beta-induced phosphoproteome in MCF-7 breast cancer cells. In total, we identify over 20,000 phosphorylation sites, of which similar to 1% are regulated up on TNF-alpha stimulation. We identify various potential novel IKK beta substrates including kinases and regulators of cellular trafficking. Moreover, we show that one of the candidates, AEG-1/MTDH/LYRIC, is directly phosphorylated by IKK beta on serine 298. We provide evidence that IKK beta-mediated AEG-1 phosphorylation is essential for I kappa B alpha degradation as well as NF-kappa B-dependent gene expression and cell proliferation, which correlate with cancer patient survival in vivo

Results from the centers for disease control and prevention's predict the 2013-2014 Influenza Season Challenge

Background: Early insights into the timing of the start, peak, and intensity of the influenza season could be useful in planning influenza prevention and control activities. To encourage development and innovation in influenza forecasting, the Centers for Disease Control and Prevention (CDC) organized a challenge to predict the 2013-14 Unites States influenza season. Methods: Challenge contestants were asked to forecast the start, peak, and intensity of the 2013-2014 influenza season at the national level and at any or all Health and Human Services (HHS) region level(s). The challenge ran from December 1, 2013-March 27, 2014; contestants were required to submit 9 biweekly forecasts at the national level to be eligible. The selection of the winner was based on expert evaluation of the methodology used to make the prediction and the accuracy of the prediction as judged against the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet). Results: Nine teams submitted 13 forecasts for all required milestones. The first forecast was due on December 2, 2013; 3/13 forecasts received correctly predicted the start of the influenza season within one week, 1/13 predicted the peak within 1 week, 3/13 predicted the peak ILINet percentage within 1 %, and 4/13 predicted the season duration within 1 week. For the prediction due on December 19, 2013, the number of forecasts that correctly forecasted the peak week increased to 2/13, the peak percentage to 6/13, and the duration of the season to 6/13. As the season progressed, the forecasts became more stable and were closer to the season milestones. Conclusion: Forecasting has become technically feasible, but further efforts are needed to improve forecast accuracy so that policy makers can reliably use these predictions. CDC and challenge contestants plan to build upon the methods developed during this contest to improve the accuracy of influenza forecasts. © 2016 The Author(s)

Wheat seed embryo excision enables the creation of axenic seedlings and Koch’s postulates testing of putative bacterial endophytes

Early establishment of endophytes can play a role in pathogen suppression and improve seedling development. One route for establishment of endophytes in seedlings is transmission of bacteria from the parent plant to the seedling via the seed. In wheat seeds, it is not clear whether this transmission route exists, and the identities and location of bacteria within wheat seeds are unknown. We identified bacteria in the wheat (Triticum aestivum) cv. Hereward seed environment using embryo excision to determine the location of the bacterial load. Axenic wheat seedlings obtained with this method were subsequently used to screen a putative endophyte bacterial isolate library for endophytic competency. This absence of bacteria recovered from seeds indicated low bacterial abundance and/or the presence of inhibitors. Diversity of readily culturable bacteria in seeds was low with 8 genera identified, dominated by Erwinia and Paenibacillus. We propose that anatomical restrictions in wheat limit embryo associated vertical transmission, and that bacterial load is carried in the seed coat, crease tissue and endosperm. This finding facilitates the creation of axenic wheat plants to test competency of putative endophytes and also provides a platform for endophyte competition, plant growth, and gene expression studies without an indigenous bacterial background

Prior traumatic brain injury is a risk factor for in-hospital mortality in moderate to severe traumatic brain injury: a TRACK-TBI cohort study.

OBJECTIVES: An estimated 14-23% of patients with traumatic brain injury (TBI) incur multiple lifetime TBIs. The relationship between prior TBI and outcomes in patients with moderate to severe TBI (msTBI) is not well delineated. We examined the associations between prior TBI, in-hospital mortality, and outcomes up to 12 months after injury in a prospective US msTBI cohort. METHODS: Data from hospitalized subjects with Glasgow Coma Scale score of 3-12 were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (enrollment period: 2014-2019). Prior TBI with amnesia or alteration of consciousness was assessed using the Ohio State University TBI Identification Method. Competing risk regressions adjusting for age, sex, psychiatric history, cranial injury and extracranial injury severity examined the associations between prior TBI and in-hospital mortality, with hospital discharged alive as the competing risk. Adjusted HRs (aHR (95% CI)) were reported. Multivariable logistic regressions assessed the associations between prior TBI, mortality, and unfavorable outcome (Glasgow Outcome Scale-Extended score 1-3 (vs. 4-8)) at 3, 6, and 12 months after injury. RESULTS: Of 405 acute msTBI subjects, 21.5% had prior TBI, which was associated with male sex (87.4% vs. 77.0%, p=0.037) and psychiatric history (34.5% vs. 20.7%, p=0.010). In-hospital mortality was 10.1% (prior TBI: 17.2%, no prior TBI: 8.2%, p=0.025). Competing risk regressions indicated that prior TBI was associated with likelihood of in-hospital mortality (aHR=2.06 (1.01-4.22)), but not with hospital discharged alive. Prior TBI was not associated with mortality or unfavorable outcomes at 3, 6, and 12 months. CONCLUSIONS: After acute msTBI, prior TBI history is independently associated with in-hospital mortality but not with mortality or unfavorable outcomes within 12 months after injury. This selective association underscores the importance of collecting standardized prior TBI history data early after acute hospitalization to inform risk stratification. Prospective validation studies are needed. LEVEL OF EVIDENCE: IV. TRIAL REGISTRATION NUMBER: NCT02119182