7 research outputs found
Biocompatible Fluorescent Core-Shell Nanoconjugates Based on Chitosan/Bi2S3 Quantum Dots
Mechanochemistry of Chitosan-Coated Zinc Sulfide (ZnS) Nanocrystals for Bio-imaging Applications
Abstract The ZnS nanocrystals were prepared in chitosan solution (0.1Â wt.%) using a wet ultra-fine milling. The obtained suspension was stable and reached high value of zeta potential (+57Â mV). The changes in FTIR spectrum confirmed the successful surface coating of ZnS nanoparticles by chitosan. The prepared ZnS nanocrystals possessed interesting optical properties verified in vitro. Four cancer cells were selected (CaCo-2, HCT116, HeLa, and MCF-7), and after their treatment with the nanosuspension, the distribution of ZnS in the cells was studied using a fluorescence microscope. The particles were clearly seen; they passed through the cell membrane and accumulated in cytosol. The biological activity of the cells was not influenced by nanoparticles, they did not cause cell death, and only the granularity of cells was increased as a consequence of cellular uptake. These results confirm the potential of ZnS nanocrystals using in bio-imaging applications