OPTIMIZATION AND SOLUBILIZATION STUDY OF NANOEMULSION BUDESONIDE AND CONSTRUCTING PSEUDOTERNARY PHASE DIAGRAM

Objective: The aim of the present study was to formulate and optimize budesonide nanoemulsions for targeting inflammation.Methods: Budesonide is only found in individuals that have used or taken this drug. It is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. The exact mechanism of the action of budesonide in the treatment of Crohn's disease is not fully understood. However, being a glucocorticosteroid, budesonide has a high local anti-inflammatory effect. The formulation was optimized for different components and the solubility study for the oil in surfactant and cosurfactant mix ratio was optimized using ternary phase diagram.Results: The surfactant mix ratio was optimized as 1:3 where the maximum concentration of the oil has solubilized and the nanoemulsion area was increased.Conclusion: Budesonide nanoemulsion for targeting inflammation and the pseudoternary phase diagram for the solubility studies and the components of different phases were optimized and achieved through this study

Vitamin changes in sweets with time and storage conditions

Vitamin changes assocd. with different temp. and period of storage were measured in sweets rasmalai and badam pista roll. A comparative study was done between these sweets from two different sweet marts. With std. colorimetric techniques the anal. was carried out and by applying statistical methods the variations were tabulated. The vitamin content (niacin and ascorbic acid) decreased with increase in temp. and storage period in accordance with moisture and pH

Development, testing and plant trails of single reagent system for coal flotation

Flotation is an important means of upgrading the fine fraction of raw coal, typically particles finer than 0.5 mm. Due to increased use of highly mechanized mining techniques large quantities of fines (< 0.5 mm) are being generated. These fines presently account for approximately 20–30% of the total plant feed. More than 140 million tones of fine coals are beneficiated by flotation worldwide annually. In coal flotation, reagents are required to enhance the hydrophobicity of coal surface. In addition to hydrophobic character, the selectivity, proper froth structure, stability and less sensitive to water chemistry are important. Water insoluble hydrocarbons are widely used as collectors in coal flotation. These collectors are basically non-polar oils like diesel, kerosene, etc. along with some frothers. Thus, it is necessary to add collector and frother separately in coal flotation. It is generally accepted that in coal flotation a single reagent system is more advantageous than the present practice of two reagent system. National Metallurgical Laboratory is involved in the flotation of coal fines using alternative single collector systems to developed specially replace fuel oils and frothers. For this purpose NML has entered into an agreement with M/s Somu Organo-Chem Pvt. Ltd. (SOCPL) Bangalore, a leading reagent manufacturer. Under this collaboration M/s SOCPL developed reagents and NML evaluated their selectivity index and application in coal flotation. Among many reagents developed and evaluated one best reagent was selected and full scale plant trails were conducted. The paper deals with the results obtained with several reagents in the laboratory and the plant trails

Eco Friendly and Cost-Effective Reagent for Coal Flotation

Conventionally, diesel in combination with a frother is used widely in flotation of coal fines. With the continuous price escalation of petroleum products and their negative impact on environment, attempts were made to formulate an eco-friendly single reagent to replace diesel-frother system without affecting the flotation performance. Laboratory flotation tests were carried out, on a coking coal sample from eastern India, that analyzed 25.67% ash and 53.97% fixed carbon using a series of reagents developed. Among them, the performance of Sokem 590C derived from a vegetable oil was found to be encouraging. Concentrate assaying 11.77% ash and 66.40% fixed carbon was obtained with yield of 56.57%. Moreover, the reagent is biodegradable and eco friendly. Based on favorable kinetics and encouraging test results, plant trials were conducted at a coal preparation plant and the superiority of this reagent was demonstrated

Comparative study of various intra ocular lens formulae by IOL master

Background: The aim and objective of the study was to calculate intraocular lens power with IOL master in 100 eyes of 100 patients with long axial lengths between 25mm to 32mm.To analyse and compare the results of various formulae by postoperative auto refractometry and corrected distance visual acuity and to know the most accurate formula for highly myopic eyes (Axial length more than 25.00 mm).Methods: Patients coming to Sarojini Devi Eye Hospital from December 2012-September 2014 for cataract surgery were considered in this study. All patients with visually significant cataract having fundus findings within normal limits were included in this study and patients of complicated cataract due to trauma, uveitis, Glaucoma and any corneal pathology were excluded from the study.Results: The Mean AL was 27.25 ± 1.25 mm, the Mean keratometric value was 43.62 ± 1.45 D, and the Mean Absolute Error (MAE) calculated by the Haigis was 0.07 DD. Compared to the MAEs generated by the other formulae, the MAE generated by the Haigis was comparable to that by the SRK/T (0.231 D), and significantly lower than those by the Hoffer Q (0.481 D) and Holladay (0.864 D).Conclusions: The Mean post-operative refractive error (spherical equivalent) was found to be the least with Haigis formula followed by SRK/T for eyes with long axial length.The HAIGIS formula has a better predictability and accuracy. The postoperative hyperopic shift was comparable between HAIGIS and SRK-T formulae the least postoperative hyperopic shift with Haigis formula compared to other formulae.

Single reagent for coal flotation

Froth flotation is widely used for the beneficiation of fine coal and collectors are important for the effective separation in flotation. Conventionally, diesel in combination with a commercial frother is used in most of the coal washeries. With the escalating costs of petroleum products and their negative impact on environment, attempts were made to formulate an eco-friendly single reagent to replace diesel-frother system without hindering the flotation process performance. NML-Madras Centre in collaboration with M/s Somu Organo Chem Pvt Ltd, has been working on the formulation and evaluation of flotation reagents. Laboratory flotation tests were carried out using series of single reagents on a coking coal sample from Jharia region in the eastern part of India with an ash content of 24.9%. The best among the single reagents, Sokem 590C, yielded a float of 56.57% at 13.97% ash in the bench scale laboratory test. Based on encouraging results of flotation tests and kinetics studies, plant trials were conducted at a coal preparation plant in eastern India. The results of plant trials using this single reagent, Sokem 590C, are highly encouraging and economical as compared to diesel-frother system and this single reagent is non-petroleum based and biodegradable

Glucose levels in first 3 days and neurodevelopmental outcome at 1 year in low birth weight infants: A cohort study

Background: Definition of neonatal hypoglycemia is still controversial. Objective: To find the effect of blood glucose (BG) levelsin the first 3 days of life, on developmental outcome at 1 year in low birth weight neonates &lt;2000 g. Methods: A prospective cohortstudy was conducted in tertiary level neonatal intensive care unit and follow-up clinic in south India. Intramural neonates admittedfrom September 2009 to August 2010 were enrolled. Perinatal and neonatal variables were recorded. Respiratory support, fluids,and feeding management were based on the standard protocols. BG was measured within 2 h, then 6 hourly for 72 h by glucometerand BG &lt;50 mg% was analyzed by hexokinase method. Infants were followed until 1 year corrected age and development age(DA) assessed by Developmental Assessment Scales for Indian Infants (DASII). Motor and mental DA at various BG levelswere compared. Composite outcome of motor or mental developmental delay; or cerebral palsy or hearing impairment or visualimpairment was analyzed, and logistic regression analysis was performed. Results: The mean birth weight and gestation of the studygroup (n=129) was 1493 g and 32.5 weeks. The 10th centile of BG in the first 72 h was 51 mg%. BG below 10th centile was seen in60 infants. The mean motor and mental DA of the infants by DASII assessment at 1 year was 11.3 and 11.5 months, respectively.The motor DA and mental DA were significantly higher until 50 mg% lowest BG level, and positive correlation was seen (r=0.26motor, 0.2 mental DA). Mean BG level, the presence of symptoms; number of episodes or small for gestation did not influence theDA. The adjusted odds for poor composite outcome when BG was below 51 mg% is 2.83 (0.65-12.3). Conclusion: Even thoughhigh-risk neonates with BG &lt;51 mg% have a lower motor DA and mental DA at 1 year, than neonates with BG &gt;50 mg%; othermorbidities do determine their composite outcome

Single reagent for graphite flotation

Generally, diesel and frother are used as reagents in graphite flotation. With the escalating cost of petroleum products and their negative impact on environment, attempts are made to formulate an eco-friendly single reagent to replace the diesel-frother system without affecting the flotation performance. CSIR-NML Madras Centre in collaboration with M/s Somu Organo Chem Pvt Ltd., India, has worked out the formulation and evaluation of single reagent on a low grade graphite ore sourced from eastern India. The petrography studies indicate that the ore primarily consists of quartz and graphite with minor quantity of mica and analyzing 87.85% ash content. The ore is crushed in stages followed by primary coarse wet grinding to 242 µm (d80). Rougher flotation is carried out in Denver flotation cell with a view to eliminate gangue as much as possible in the form of primary tailings with minimal loss of carbon. Regrinding of rougher concentrate to 216 µm (d80) is opted to improve the liberation of graphite values. This approach involving a primary coarse grinding and regrinding of rougher float followed by multi-stage cleaning using this single reagent is found to yield better recovery and grade when compared with that of the dual reagent system. A final concentrate of 12.03% weight recovery with 3.22% ash could be achieved. Based on encouraging laboratory studies using the single reagent, plant trials were carried out. From the cost benefit analysis, this single reagent proves to be an economically viable in place of diesel-frother for processing low grade graphite