THE CLINICOPATHOLOGICAL STUDY OF NON-NEOPLASTIC LESIONS OF NASAL CAVITY AND PARANASAL SINUSES IN A TERTAIRY CARE TEACHING HOSPITAL: NON NEOPLASTIC LESIONS OF NASAL CAVITY AND PARANASAL SINUSES

Objective: A variety of non-neoplastic lesions involving nasal cavity (NC) and paranasal sinuses (PNS) are encountered in clinical practice. The clinical features, symptoms and advanced imaging technique help to reach a provisional diagnosis but histopathological examination remains the mainstay of final definitive diagnosis. There is lack of studies that exclusively cover non-neoplastic lesions of sinonasal region. Hence this study was done with the aim of examining the clinicopathological features of various non-neoplastic lesions of nasal cavity and paranasal sinuses. Method: The formalin fixed specimens of polypectomy/ biopsy were received with complete clinical and radiological features in the department of Pathology. Routine gross examination and required number of sections were taken and stained with haematoxylin and eosin stain. Periodic acid Schiff’s was used wherever necessary. Results: Histologically, maximum number of cases were of inflammatory polyp (57%), followed by Allergic polyp (18%), and Invasive Fungal Sinusitis- Mucormycosis (17%). Mucormycosis was found in patients who have recovered from COVID along with steroid intake history or had diabetes mellitus or had multiple comorbidites along with COVID recovery and steroid intake. Conclusion: Amongst the non-neoplastic lesion, inflammatory polyp is the commonest lesion followed by allergic polyp. Significant number of mucormycosis cases was seen owing to the ongoing COVID pandemic and liberal use of corticosteroids in the treatment. &nbsp

Primary plasmablastic lymphoma of the central nervous system in an immunocompetent man: A case report and review of literature

Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma classically occurring in individuals infected with human immunodeficiency virus (HIV). It has a predilection for the oral cavity and jaw. However, recent case reports have shown this variety of lymphoma in the stomach, lung, nasal cavity, cervical lymph nodes and jejunum in HIV-negative individuals. In this manuscript we report a case of primary PBL of brain in an HIV-negative heterosexual man, who presented with multiple episodes of seizures and hemiparesis. It proved a diagnostic challenge as initial stereotactic brain biopsy showed only few necrotic fragments and possibility of glioblastoma multiforme was rendered. Later patient underwent craniotomy and subsequent histopathology combined with immunohistochemistry led us in making a correct diagnosis of extramedullary PBL. Extensive systemic work up failed to reveal any disease outside the central nervous system. Only single case of primary PBL of brain in HIV-negative individual has been reported until date. To the best of our knowledge, this is the second report to suggest such an association