Reaction rates in fast nuclear reactors

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In vitro activity of antiamoebic drugs against clinical isolates of Entamoeba histolytica and Entamoeba dispar

BACKGROUND: Amoebiasis is a major public health problem in tropical and subtropical countries. Although a number of antiamoebic agents are used for its treatment, yet the susceptibility data on clinical isolates of Entamoeba histolytica and Entamoeba dispar are not available. Therefore, the present study was aimed to assess the in vitro susceptibility of clinical isolates of E. histolytica and E. dispar to metronidazole, chloroquine, emetine and tinidazole. METHODS: A total of 45 clinical isolates (15 E. histolytica and 30 E. dispar) were maintained in polyxenic cultures followed by monoxenic cultures. In vitro drug sensitivity (IC(50)) of clinical isolates and standard reference strain of E. histolytica (HM1: IMSS) was assessed by nitro blue tetrazolium (NBT) reduction assay after exposure to various concentrations of each drug. RESULTS: The results showed that all clinical isolates had a higher IC(50 )compared to reference strain to all the four drugs. E. histolytica isolates appeared to be more susceptible [IC(50 )(μm) 13.2,26.3,31.2 and 12.4] compared to E. dispar isolates [IC(50)(μm) 15.6,28.9,32.8 and 13.2] and the reference strain of E. histolytica [IC(50 )(μm) 9.5, 15.5, 29.9 and 10.2] to the metronidazole, chloroquine, emetine and tinidazole respectively. CONCLUSIONS: The results indicate that till date, Entamoeba isolates in India do not seem to be resistant to the commonly used antiamoebic drugs

Prevalence of Bronchogenic carcinoma in the North Indian Population

Aim: This original research article aims to study the Prevalence of Bronchogenic carcinoma in the North Indian Population. Material & Method: The present study includes 150 patients with intrathoracic space-occupying lesions, of which 42 patients with bronchogenic carcinoma were seen at SS hospital Banaras Hindu University, Varanasi, UP. Most of the patients studied were from the thoracic surgery section, while few patients were taken from other departments of SS hospital. The age of those patients varied widely, starting from 10 years to 60 years. The bulk of the patients were young adults and middle-aged persons, with 35 males and seven females. During this study, patients were investigated in systemic order with the progression of symptoms from the onset, development of latest symptoms and treatment taken before if any, history of tuberculosis, chronic cough, smoking, and contact with were recorded. The patient's vitals were recorded, and routine pathological investigation including blood count, hemoglobin and specific procedure like radiological method, sputum and bronchoscopy were performed. Result: Maximum patients were in the age group of 41 to 50 years. Forty-two patients were diagnosed with Bronchogenic carcinoma, a definitive diagnosis was confirmed by Clinical & Radiological (chest X-ray & CT Scan) in 24 (16%), by Bronchoscopic examination & Biopsy in 15 (10%) and by thoracotomy in 03(2%). The maximum age group among the cases were 41-60. The most common symptom was Cough with expectoration in 33 patients (78.5%), followed by Haemoptysis and Dyspnea in 30 cases (71.4%). Fever was least common with 6 cases. It was observed that 18 patients (43%) had the habit of smoking for more than 18 years. Conclusion: This study provides a framework for assessing the prevalence of bronchogenic carcinoma in the North Indian population and proves that smoking is a potential risk factor in bronchogenic carcinoma. Prevalence of Bronchogenic Carcinoma among all cases of Intrathoracic Lesions Cases 28 % and among all subjects who undergone for screening in one year – 2.84

Precipitating Factors of Psoriasis in North Indian Population

Aim: This study aims to study precipitating factors of psoriasis in the north Indian population. Material & Method:Two hundred twenty-eight psoriasis patients regardless of age, sex, religion,occupation, attending the skin, and V.D. outpatients Department, B.R.D. Medical College, Gorakhpurfor were taken because of the subject of this study. The bulk of patients belonged to the Eastern U.P.and adjoining areas of Bihar and Nepal. The clinical criteria for diagnosis of psoriasis were thepresence of Erythematous and papulosquamous lesions with loosely adherent silvery-white scales.The auspitz's sign was demonstrated all told the cases. The detailed clinical history and examinationwere recorded. Each patient was categorized into mild to severe psoriasis. Result: The maximumpercentage of cases was aggravated by weather (winter), 55.26%, next to that was trauma 27.19%, and least after infections 4.35%. The summer and spring seasons showed an improved effecton the condition of psoriasis. Alcohol, smoking, and mental stress found no relation with psoriasis.In most cases, where the infection was associated with the disease, it had been aggravated only inchildren, and young adults and lesions were of guttate type. Pregnancy had no effect in 25.43% ofcases, while the disease was improved in 3.50% of patients and worsen in 4.35% of cases. Conclusion: Psoriasis is positively correlated with the winter season and negatively associated withSummer and Spring

Psoriatic Arthritis in the Eastern Part of Uttar Pradesh

Aim: This original research article aims to study Psoriatic Arthritis in the Eastern Part of Uttar Pradesh. Material & Method: Two hundred twenty-eight patients of psoriasis regardless of age, sex, religion, occupation, attending the skin, and V. D. outpatients Department, B.R.D. Medical College, Gorakhpur for were taken because of the subject of this study. The bulk of patients belonged to the Eastern U.P. and adjoining areas of Bihar and Nepal. The clinical criteria for diagnosis of psoriasis were the presence of Erythematous and papulosquamous lesions with loosely adherent silvery-white scales. The auspitz's sign was demonstrated all told the cases. The detailed clinical history and examination were recorded with Tests for Rheumatoid factor and serum uric acid, Radiographs of both hands and feet, Radiographs of the lumbosacral Spine and both sacroiliac joints and Radiographs of affected joints (if any). Each patient was categorised into mild to severe psoriasis. Result: The total number of psoriatic arthritis cases was found, 26 of which male were 17 and female were 9. The maximum number of Arthritis cases, 18.5%, were seen with severe disease (PASI score > 15) with higher occurrence in males. The maximum number of joints involved distal interphalangeal joint was 69.2 3%, and the minimum number of joints involved was significant joint 7.69%. Conclusion: Psoriasis care is unbalanced, with men being more likely to undergo specialist treatment than women, causing higher distal interphalangeal (D.I.P.) joint arthropathy