A retrospective analysis of COVID-19 infection among healthcare workers of south east Assam, India

Background: Health care workers (HCWs) are the frontline warriors, more prone to contracting coronavirus disease 2019 (COVID-19). They also have tremendous possibility of serving as transmission vectors to others. In India there is paucity of data on COVID-19 infection among HCWs. Therefore, it is important to evaluate the infection risk, clinical features, and source of infection, transmission and outcome in HCWs to safeguard them and to check further community spread.Methods: The aim of the study was to investigate the presence of COVID-19 infection among HCWs and to understand the risk factors for infection. Demographic and clinical data of HCWs declared SARS-COV-2 real time RT-PCR positive by VRDL, SMCH, Silchar during June 2020 to July 2021 was obtained from ICMR portal.Results: On data analysis it was found that during the study period a rate of 3.95% (316 out of 7997 cases) infection was among HCWs. Their mean age was 36 years. With maximum cases among male staffs (57.9%), and most common age group was young generation of 17-29 years. The peak acquisition of infection was in July 2020 during ATSP surveillance with 45.5% of infected HCWs. Of the infected HCWs majority were asymptomatic (74%) Although hospitalization rate was high i.e. 82.9% but severity was low with no mortality. Co-morbidity among infected cases was low 23.4%, usually in the aged group of ≥45 years. Doctors/PGTs and Nurses were the highly affected group.Conclusions: Safeguarding the HCWs from infection is the critical need for empowering the healthcare system and overcoming any pandemic in future as well. 

Prolactin and thyroid stimulating hormone affecting the pattern of LH/FSH secretion in patients with polycystic ovary syndrome: A hospital-based study from North East India

Introduction: Polycystic ovary syndrome (PCOS) is one of the most important endocrinal diseases in reproductive age group, clinically manifested by hyperandrogenism and anovulation and different other metabolic disturbances that may have important implications for long-term health. Aim and Objective: The aim of this study was to determine the incidence of abnormal luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio in women with polycystic ovary and to assess the influence of prolactin and thyroid-stimulating hormone (TSH) in the elevated LH/FSH ratio. Study Design: Retrospective observational study. Materials and Methods: Eighty-five women in reproductive age diagnosed with PCOS between June 2012 to June 2014 at the Department of Obstetrics and Gynecology in a tertiary care hospital were selected for the study. Serum LH and FSH levels were determined and LH/FHS ratio (normal range ≤2) calculated in the study subjects. They underwent a detailed clinical, hormonal, and metabolic evaluation, which was performed between the second and third days of a natural or induced menstrual period. Results: Elevated LH/FSH ratio was found in 60 women (70.58%). Normal gonadotropin ratio was detected in 25 women (29.41%). Statistically significant differences in serum TSH levels were noted between groups with normal and elevated LH/FSH ratio. However, no statistically significant difference was noted in other endocrine parameters. Further analysis revealed a slight negative correlation of TSH with prolactin in the study subjects of PCOS with an 'r' value of − 0.3. Conclusions: LH/FSH ratio is one of the characteristic attribute of PCOS women. In the present study, this abnormality was detected in 70% of patients. Hypothyroidism was a common endocrinal abnormality and prolactin was inversely correlated to TSH levels in PCOS patients