Do younger women with non-metastatic and non-inflammatory breast carcinoma have poor prognosis?

BACKGROUND: Controversy abounds over whether breast cancer in younger women is more aggressive than those in older. The aim of the study was to assess the influence of age on long-term survival of women with breast carcinoma. MATERIALS AND METHODS: Patients with non-metastatic and non-inflammatory invasive breast carcinoma treated at the Regional Cancer Centre, Trivandrum, Kerala, India during 1990–93 were divided into 4 age groups as < 40 years, 40–49, 50–59, and > 60 years. The overall survival (OS) for each age group was estimated using the Kaplan-Meier method in relation to the primary tumor (T) and the axillary node status (N). The OS of the various age groups were compared using the log-rank test. Hazard ratio and 95% confidence interval for each age group was estimated using Cox-regression model after adjusting for T and N. RESULTS: Between 1990–1993, 1701 women (26%, <40 years) reported with non-metastatic and non-inflammatory invasive breast carcinoma. Overall survival (OS) of all the women was 52.6 % (standard error 1%) at 10 years. The OS for women with age < 40 years and with T3 and T4 disease status was 36.6% and 10.4% respectively and for those in 40–49 age group was 41.9% and 33.5%. The 10-year OS for women with node positive (N1) disease was 24.6% in < 40 years and 45.2% in the 40–49 age group (p = 0.0006). After adjusting for tumor and node stage the relative risk for death was 24% lower for women in 40–49 age group as compared to women <40 years of age. CONCLUSION: Women under 40 years with T3/ T4 breast lesions and/or positive axillary nodes were found to have a significantly poorer survival

Tuberculosis and metastatic carcinoma coexistence in axillary lymph node: A case report

BACKGROUND: Coexistence of cancer and tuberculosis in axillary lymph nodes is rare. Only seven cases have been reported in the literature. CASE REPORT: We report here a case of infiltrating ductal carcinoma breast metastasizing to the axillary lymph node along with tubercular granuloma in the same lymph node without primary mammary or pulmonary tuberculosis. CONCLUSION: Primary tuberculosis coexisting with carcinoma is of rare occurrence. A possibility should always be borne in mind especially in patients from endemic areas

A review on metabolomics for quality improvement of fruit crops

The field of metabolomics is gaining ground in plant biology, and its potential uses in agricultural biotechnology are expanding. Metabolomics is the study of metabolites, which are extremely small molecules. The phenotype correlates more strongly with the metabolomic profile than with the genomic, transcriptomic, or proteomic profiles. Plant metabolic profiling is another application of metabolomics that has been used to identify previously uncharacterized genes and their roles. The use of metabolomics to evaluate mutants and transgenic plants, track fruit development, determine quality, detect disease resistance, determine abiotic stress tolerance, etc., has become increasingly important. Metabolomics has also been applied to plant studies, which have become increasingly important in efforts to improve fruit quality. We first assess the profound influence metabolomics has had over the past decade, then provide an introduction to the field, its current contribution, and the hope it holds for enhancing fruit production

Carrier Transport in High Mobility InAs Nanowire Junctionless Transistors

Ability to understand and model the performance limits of nanowire transistors is the key to design of next generation devices. Here, we report studies on high-mobility junction-less gate-all-around nanowire field effect transistor with carrier mobility reaching 2000 cm2/V.s at room temperature. Temperature-dependent transport measurements reveal activated transport at low temperatures due to surface donors, while at room temperature the transport shows a diffusive behavior. From the conductivity data, the extracted value of sound velocity in InAs nanowires is found to be an order less than the bulk. This low sound velocity is attributed to the extended crystal defects that ubiquitously appear in these nanowires. Analyzing the temperature-dependent mobility data, we identify the key scattering mechanisms limiting the carrier transport in these nanowires. Finally, using these scattering models, we perform drift-diffusion based transport simulations of a nanowire field-effect transistor and compare the device performances with experimental measurements. Our device modeling provides insight into performance limits of InAs nanowire transistors and can be used as a predictive methodology for nanowire-based integrated circuits.Comment: 22 pages, 5 Figures, Nano Letter

Sustainable Livestock Production in Nepal: A Focus on Animal Nutrition Strategies

publishedVersio

Spatial distribution of outbreak of locust swarms: a geographical analysis of vulnerability and preventions in India

Current outbreak of locust swarms in the different parts of the world has also emerged as a big problem for the Indian agricultural sector and associated livelihood options. Being known for its transient nature, the locust swarms containing millions of locusts. These swarms are, therefore, one of the most dangerous pests in the world that may have a disastrous impact on food, food crops, fodder and food security around the world. The outbreak has been historically noticed in several regions of the world which effected the agriculture system of the many countries and major cause for the slowdown in the economy. This paper examines the origin and migration trends of locust swarms in the world in general and India in particular.  Also paper evaluates the recent outbreak of locusts in India along with assessing its devastating impact on Indian Agricultural Sector and the track routes of the swarms in India in different months. In the end, the paper highlights preventive measures that have been used in monitoring and preventions of locust swarms. The outbreaks of locust in India is not new, but have been encountered in the past too. The intensity and number of hives and migratory frequency is increasing with time. The Area, magnitude and impacts of the locust swarms is also growing with time and space. Since the outbreak results in social, economic and environmental consequences, therefore, adequate measures and planning are required to tackle the crisis.Keywords:  Locusts, Swarms, Vulnerability, Prevention Measures, Spatial distributio

Improving fertilizer recommendations for Nepalese farmers with the help of soil-testing mobile van

Smallholder farmers dominate agriculture in Nepal. These farmers have poor knowledge about agriculture and lack of support for soil management and integrated plant-nutrient systems. Focusing on the importance and need for soil-fertility management, a soil-testing mobile van program has recently been introduced in Nepal by Soil Management Directorate, Hariharbhawan. With the introduction of the mobile lab, famers can get their soil tested for nutrient deficiencies and fertilizer requirements at their doorsteps. Using mobile lab, spatial distributions of chemical properties, including pH, organic matter (OM), total nitrogen (N), available phosphorus (as P2O5), and available potassium (as K2O) were examined in soil samples taken from the 0 to 15 cm depth from selected agricultural fields in eight different districts in the mid-hills and Terai regions of Nepal. Tests conducted on 1,479 soil samples in the soil-testing mobile van revealed the following: the mean soil OM ranged from 0.01 to 1.77%; total N content ranged from 0.01 to 0.08%; mean available P2O5 ranged from 16.47 to 197.82 kg ha−1; and mean available K2O ranged from 84.3 to 422.57 kg ha−1. For each crop to be grown, farmers were provided with individual soil health reports and fertilizer recommendations (rate, amount, and type). This program not only allows scientists and farmers to work closely and share information but also serves as a model for the nation to successfully transfer technology for improving soil health and sustainability