Probing the Super Star Cluster Environment of NGC 1569 Using FISICA

We present near-IR JH spectra of the central regions of the dwarf starburst galaxy NGC 1569 using the Florida Image Slicer for Infrared Cosmology and Astrophysics (FISICA). The dust-penetrating properties and available spectral features of the near-IR, combined with the integral field unit (IFU) capability to take spectra of a field, make FISICA an ideal tool for this work. We use the prominent [He I] (1.083\mu m) and Pa\beta (1.282 \mu m) lines to probe the dense star forming regions as well as characterize the general star forming environment around the super star clusters (SSCs) in NGC 1569. We find [He I] coincident with CO clouds to the north and west of the SSCs, which provides the first, conclusive evidence for embedded star clusters here.Comment: 6 pages, 3 figures, accepted for publication in the MNRA

Some new results concerning the vacuum in Dirac Hole Theory

In Dirac's hole theory the vacuum state is generally believed to be the state of minimum energy. It will be shown that this is not, in fact, the case and that there must exist states in hole theory with less energy than the vacuum state. It will be shown that energy can be extracted from the hole theory vacuum state through the application of an electric field.Comment: Accepted by Physica Scripta, 19 page

Telephone administered cognitive behaviour therapy for treatment of obsessive compulsive disorder: randomised controlled non-inferiority trial

This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.To compare the effectiveness of cognitive behaviour therapy delivered by telephone with the same therapy given face to face in the treatment of obsessive compulsive disorder.NHS Executive North West (Research and Development Fund

Overexpression of Plastid Transketolase in Tobacco Results in a Thiamine Auxotrophic Phenotype

To investigate the effect of increased plastid transketolase on photosynthetic capacity and growth, tobacco (Nicotiana tabacum) plants with increased levels of transketolase protein were produced. This was achieved using a cassette composed of a full-length Arabidopsis thaliana transketolase cDNA under the control of the cauliflower mosaic virus 35S promoter. The results revealed a major and unexpected effect of plastid transketolase overexpression as the transgenic tobacco plants exhibited a slow-growth phenotype and chlorotic phenotype. These phenotypes were complemented by germinating the seeds of transketolase-overexpressing lines in media containing either thiamine pyrophosphate or thiamine. Thiamine levels in the seeds and cotyledons were lower in transketolase-overexpressing lines than in wild-type plants. When transketolase-overexpressing plants were supplemented with thiamine or thiamine pyrophosphate throughout the life cycle, they grew normally and the seed produced from these plants generated plants that did not have a growth or chlorotic phenotype. Our results reveal the crucial importance of the level of transketolase activity to provide the precursor for synthesis of intermediates and to enable plants to produce thiamine and thiamine pyrophosphate for growth and development. The mechanism determining transketolase protein levels remains to be elucidated, but the data presented provide evidence that this may contribute to the complex regulatory mechanisms maintaining thiamine homeostasis in plants

A Mercury Lander Mission Concept Study for the Next Decadal Survey

Mariner 10 provided our first closeup reconnaissance of Mercury during its three flybys in 1974 and 1975. MESSENGERs 20112015 orbital investigation enabled numerous discoveries, several of which led to substantial or complete changes in our fundamental understanding of the planet. Among these were the unanticipated, widespread presence of volatile elements (e.g., Na, K, S); a surface with extremely low Fe abundance whose darkening agent is likely C; a previously unknown landformhollows that may form by volatile sublimation from within rocks exposed to the harsh conditions on the surface; a history of expansive effusive and explosive volcanism; substantial radial contraction of the planet from interior cooling; offset of the dipole moment of the internal magnetic field northward from the geographic equator by ~20% of the planets radius; crustal magnetization, attributed at least in part to an ancient field; unexpected seasonal variability and relationships among exospheric species and processes; and the presence in permanently shadowed polar terrain of water ice and other volatile materials, likely to include complex organic compounds. Mercurys highly chemically reduced and unexpectedly volatile-rich composition is unique among the terrestrial planets and was not predicted by earlier hypotheses for the planets origin. As an end-member of terrestrial planet formation, Mercury holds unique clues about the original distribution of elements in the earliest stages of the Solar System and how planets (and exoplanets) form and evolve in close proximity to their host stars. The BepiColombo mission promises to expand our knowledge of this planet and to shed light on some of the mysteries revealed by the MESSENGER mission. However, several fundamental science questions raised by MESSENGERs pioneering exploration of Mercury can only be answered with in situ measurements from the planets surface

Efficient Implementation and the Product State Representation of Numbers

The relation between the requirement of efficient implementability and the product state representation of numbers is examined. Numbers are defined to be any model of the axioms of number theory or arithmetic. Efficient implementability (EI) means that the basic arithmetic operations are physically implementable and the space-time and thermodynamic resources needed to carry out the implementations are polynomial in the range of numbers considered. Different models of numbers are described to show the independence of both EI and the product state representation from the axioms. The relation between EI and the product state representation is examined. It is seen that the condition of a product state representation does not imply EI. Arguments used to refute the converse implication, EI implies a product state representation, seem reasonable; but they are not conclusive. Thus this implication remains an open question.Comment: Paragraph in page proof for Phys. Rev. A revise

A critical assessment of data derived from Coral Cay Conservation volunteers.

ABSTRACT Since 1986, Coral Cay Conservation (CCC) has utilized a workforce of over 900 speciallytrained volunteer divers to collect detailed topographic, bathymetric and biological data for the establishment of management plans for selected areas of the Belize barrier reef. The biological data recorded are ordinal and reflect the abundance of reef organisms including fish, macroalgae and hermatypic corals on a scale of 0-5. Substrate composition and the coverage of principal biotic classes are also visually assessed using an ordinal scale of 0-5. An exercise was carried out to assess the accuracy and consistency of data recorded by volunteers. Transects were laid in each of the major reef zones and in lagoon habitats. Each transect was surveyed independently by six teams of trained volunteers and compared to a reference obtained by experienced CCC staff. Analyses were carried out to test the accuracy and consistency of the coral, macroalgal and habitat data. Further analyses sought to quantify the proportion of species correctly identified, the frequency of erroneous species recordings and the variation of abundance ratings. The overall accuracy of coral surveys varied from 52-70% with the poorer values obtained in deeper outer and inner drop-off reef zones. The trend of reduced surveyor performance in deeper water is discussed in terms of physical, physiological and psychological phenomena. Inter-group consistency exhibited a similar bathymetric trend to that found for coral accuracy. Macroalgae were generally accurately and consistently recorded. No clear trend of improved accuracy and consistency following greater survey experience was apparent. Substrate composition and biological cover were recorded with an accuracy exceeding 90% in seagrass habitats and 70-90% in reef sites. A number of recommendations are made to improve survey methodology and volunteer training

A mathematical model for fibro-proliferative wound healing disorders

The normal process of dermal wound healing fails in some cases, due to fibro-proliferative disorders such as keloid and hypertrophic scars. These types of abnormal healing may be regarded as pathologically excessive responses to wounding in terms of fibroblastic cell profiles and their inflammatory growth-factor mediators. Biologically, these conditions are poorly understood and current medical treatments are thus unreliable. In this paper, the authors apply an existing deterministic mathematical model for fibroplasia and wound contraction in adult mammalian dermis (Olsenet al., J. theor. Biol. 177, 113–128, 1995) to investigate key clinical problems concerning these healing disorders. A caricature model is proposed which retains the fundamental cellular and chemical components of the full model, in order to analyse the spatiotemporal dynamics of the initiation, progression, cessation and regression of fibro-contractive diseases in relation to normal healing. This model accounts for fibroblastic cell migration, proliferation and death and growth-factor diffusion, production by cells and tissue removal/decay. Explicit results are obtained in terms of the model processes and parameters. The rate of cellular production of the chemical is shown to be critical to the development of a stable pathological state. Further, cessation and/or regression of the disease depend on appropriate spatiotemporally varying forms for this production rate, which can be understood in terms of the bistability of the normal dermal and pathological steady states—a central property of the model, which is evident from stability and bifurcation analyses. The work predicts novel, biologically realistic and testable pathogenic and control mechanisms, the understanding of which will lead toward more effective strategies for clinical therapy of fibro-proliferative disorders

The Representation of Natural Numbers in Quantum Mechanics

This paper represents one approach to making explicit some of the assumptions and conditions implied in the widespread representation of numbers by composite quantum systems. Any nonempty set and associated operations is a set of natural numbers or a model of arithmetic if the set and operations satisfy the axioms of number theory or arithmetic. This work is limited to k-ary representations of length L and to the axioms for arithmetic modulo k^{L}. A model of the axioms is described based on states in and operators on an abstract L fold tensor product Hilbert space H^{arith}. Unitary maps of this space onto a physical parameter based product space H^{phy} are then described. Each of these maps makes states in H^{phy}, and the induced operators, a model of the axioms. Consequences of the existence of many of these maps are discussed along with the dependence of Grover's and Shor's Algorithms on these maps. The importance of the main physical requirement, that the basic arithmetic operations are efficiently implementable, is discussed. This conditions states that there exist physically realizable Hamiltonians that can implement the basic arithmetic operations and that the space-time and thermodynamic resources required are polynomial in L.Comment: Much rewrite, including response to comments. To Appear in Phys. Rev.