Web Service Based News Portal

Providing web services for smart phones is the currently recent booming topic, this happened because the smart phones are used in almost every area, where today’s user uses it for mobile banking, emailing, searching location and data. Smart phones are advanced in terms of processing power, memory, an embedded camera, sensors and same time parallel advancement in wireless network and software web technologies. This project will direct our work in the current generation platform technologies and standards such as Android OS and REST for News Portal. It is a complete news portal showing all the news around the nation in an interactive fashion at one place. It aims in bringing more simplicity for obtaining news about any issue round the nation. Every newspaper and news channel publishes the news on their website. So a person has to visit various websites if the user needs information about any current news in which ever language the user wants. So this portal aims to bring all the news of all different languages grouped together under one banner by provisioning web services. All sorts of news ranging from breaking news to cricket news are covered over here. Information regarding daily horoscope as well as latest stock prices are also obtained in this single portal. Mobile devices (Smart phones, PDA, Tablets), Mobile web services and wireless communications, by the year 2020 will be expected to play a central role in all aspects of our lives. The Mobile web service provisioning is substantially expanding on the concept of ‘Anywhere, Anytime and on Any Device’ to a new paradigm ubiquitous mobile computing. It is used to improve access to meaningful, quickly and required information and content through mobile web services. Many of the problems of mobile web services can be solved by targeting the distributed nature and isolated deployment of mobile applications. One of the most promising way to create viable web services for mobile devices is to add extra intelligence to the web services, both on the web service provider and the web service consumer

News House - A Sublime Horizontal Portal

Ensuring web services for smart phones is the recent important topic, this initiated because of the multiple uses of smart phone, today’s modern day user uses it for mobile banking, email, searching location and data. Smart phones are sophisticated in terms of processing speed, memory, an embedded camera, sensors and same time parallel state of art in wireless network and software web technologies. This project will guide our work in the current generation platform technologies and standards such as Android OS and REST for News Portal. It is an accomplished news portal displaying multiple news from across the nation in a collaborating manner at a single location. It focuses in bringing more ease for gathering news about any topic from across the nation. Each newspaper and news channel displays the news on their websites. So an individual needs to visit multiple websites if the individual requires knowledge about any particular news in any language the user wants. So this portal focuses in bringing multiple news of multiple languages grouped together under one platform by providing web services. Multiple types of news right from breaking news to sports news are roofed over here. Knowledge about daily horoscope along with updated stock prices is gained in this single portal. Mobile equipments (Smart phones, PDA, Tablets), Mobile web services and wireless communications, by the year 2020 will play a major role in all conditions of our lives. It is used to develop access to meaningful and required data and content through mobile web services. Most of the issues of mobile web services can be resolved by concentrating on the dispersed nature and remote disposition of mobile applications. One of the most likely way to develop viable web services for mobile devices is to add more intelligence to the web services

Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells

The transcriptional repressors Snail and Slug contribute to cancer progression by mediating epithelial-mesenchymal transition (EMT), which results in tumor cell invasion and metastases. We extend this current understanding to demonstrate their involvement in the development of resistance to radiation and paclitaxel. The process is orchestrated through the acquisition of a novel subset of gene targets that is repressed under conditions of stress, effectively inactivating p53-mediated apoptosis, while another subset of targets continues to mediate EMT. Repressive activities are complemented by a concurrent derepression of specific genes resulting in the acquisition of stem cell-like characteristics. Such cells are bestowed with three critical capabilities, namely EMT, resistance to p53-mediated apoptosis, and a self-renewal program, that together define the functionality and survival of metastatic cancer stem cells. EMT provides a mechanism of escape to a new, less adverse niche; resistance to apoptosis ensures cell survival in conditions of stress in the primary tumor; whereas acquisition of "stemness" ensures generation of the critical tumor mass required for progression of micrometastases to macrometastases. Our findings, besides achieving considerable expansion of the inventory of direct genes targets, more importantly demonstrate that such elegant cooperative modulation of gene regulation mediated by Snail and Slug is critical for a cancer cell to acquire stem cell characteristics toward resisting radiotherapy- or chemotherapy-mediated cellular stress, and this may be a determinative aspect of aggressive cancer metastases