Frankenstein: A Feminist Birth Myth of Morbid Conception

In the context of Mary Shelley’s biography and prose style, the theme and structure of Frankenstein indicate that, in addition to being an esteemed work of gothic horror, the novel is a feminist birth myth: a perverse story of maternity and a scathing critique of patriarchal dominance over the feminine. Frankenstein, as a maternal figure, repeatedly seeks to smother female sexuality and usurp heterosexual reproduction through grotesque and unnatural means. The ensuing death and violence are consequences of Frankenstein’s inadequacy as a mother and the insufficiency of masculinity. The monster’s morbid conception and subsequent murders intertwine birth and death in profound ways that mirror Shelley’s own traumatic experiences with maternity. Her life and experiences manifest in Frankenstein’s character to create a birth myth which despite its proto-feminist undertones, earned immediate success in literary climate of the 19th century which only tolerated women writing emotive works about domesticity

Eminent domain

"May 2014."Thesis supervisor: Assistant Professor Joe Johnson.Includes bibliographical references (pages 33-35)

We Don\u27t Know Where We\u27re Going But We\u27re On Our Way

Photograph of soldiers; Illustration of designshttps://scholarsjunction.msstate.edu/cht-sheet-music/5627/thumbnail.jp

A remembrance of things (best) forgotten: The 'allegorical past' and the feminist imagination

This is the author's PDF version of an article published in Feminist theology© 2012. The definitive version is available at http://fth.sagepub.com/This article discusses the US TV series Mad Men, which is set in an advertising agency in 1960s New York, in relation to two key elements which seem significant for a consideration of the current state of feminism in church and academy, both of which centre around what it means to remember or (not) to forget

Less than the sum of its parts : the dust-corrected Hα luminosity of star-forming galaxies explored at different spatial resolutions with MaNGA and MUSE

Funding: NVA would like to thank the University of St Andrews for providing support during her visit. NVA acknowledges support of the Royal Society and the Newton Fund via the award of a Royal Society–Newton Advanced Fellowship (grant NAF\R1\180403), and of Fundação de Amparo à Pesquisa e Inovação de Santa Catarina (FAPESC) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). AW acknowledges financial support from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) process number 2019/01768-6. MG receives funding from the European Research Council (ERC) under the European Union Horizon 2020 research and innovative programme (MagneticYSOs programme, grant agreement Nber 679937). EWP, RSK, SR, SCOG and DR acknowledge funding from the Deutsche Forschungsgemeinschaft (DFG) via the Collaborative Research Center (SFB 881) ‘The Milky Way System (subprojects A1, B1, and B2) and from the Heidelberg Cluster of Excellence STRUCTURES in the framework of Germany’s Excellence Strategy (grant EXC-2181/1- 390900948).The Hα and Hβ emission line luminosities measured in a single integrated spectrum are affected in non-trivial ways by point-to-point variations in dust attenuation in a galaxy. This work investigates the impact of this variation when estimating global Hα luminosities corrected for the presence of dust by a global Balmer decrement. Analytical arguments show that the dust-corrected Hα luminosity is always underestimated when using the global Hα/Hβ flux ratio to correct for dust attenuation. We measure this effect on 156 face-on star-forming galaxies from the Mapping Nearby Galaxies at APO (MaNGA) survey. At 1–2 kpc spatial resolution, the effect is small but systematic, with the integrated dust-corrected Hα luminosity underestimated by 2–4 per cent (and typically not more than by 10 per cent), and depends on the specific star formation rate of the galaxy. Given the spatial resolution of MaNGA, these are lower limits for the effect. From Multi Unit Spectroscopic Explorer (MUSE) observations of NGC 628 with a resolution of 36 pc we find the discrepancy between the globally and the point-by-point dust-corrected Hα luminosity to be 14 ± 1 per cent, which may still underestimate the true effect. We use toy models and simulations to show that the true difference depends strongly on the spatial variance of the Hα/Hβ flux ratio, and on the slope of the relation between Hα luminosity and dust attenuation within a galaxy. Larger samples of higher spatial resolution observations are required to quantify the dependence of this effect as a function of galaxy properties.PostprintPeer reviewe

Warpfield population synthesis: The physics of (extra-)Galactic star formation and feedback-driven cloud structure and emission from sub-to-kpc scales

We present a novel method to model galactic-scale star formation and emission of star clusters and a multiphase interstellar medium (ISM). We combine global parameters, including star formation rate and metallicity, with the 1D cloud evolution code warpfield to model the sources of feedback within a star-forming galaxy. Within individual star-forming regions, we include stellar evolution, stellar winds, radiation pressure, and supernovae, all coupled to the dynamical evolution of the 1D parental cloud in a highly non-linear fashion. Heating of the diffuse galactic gas and dust is calculated self-consistently with the age-, mass-, and density-dependent escape fractions of photons from these fully resolved local star-forming regions. We construct the interstellar radiation field, and we employ the multifrequency radiative transfer code polaris to produce synthetic emission maps for a one-to-one comparison with observations. We apply this to a cosmological simulation of a Milky-Way-like galaxy built-up in a high-resolution MHD simulation of cosmic structure formation. From this, we produce the multiscale/phase distribution of ISM density and temperature and present a synthesized all-sky H α map. We use a multipole expansion to show that the resulting maps reproduce all observed statistical emission characteristics. Next, we predict [S iii] 9530 Å, a key emission line that will be observed in several large forthcoming surveys. It suffers less extinction than other lines and provides information about star formation in very dense environments that are otherwise observationally inaccessible optically. Finally, we explore the effects of differential extinction, and discuss the consequences for the interpretation of H α emission at different viewing angles by an extragalactic observer

Application of REVEAL Lite 2 and COMPERA 2.0 risk scores to patients with pulmonary arterial hypertension switching to riociguat in the REPLACE study

\ua9 2024In Riociguat rEplacing PDE5i therapy evaLuated Against Continued PDE5i thErapy (REPLACE) (NCT02891850), improvements in risk status were observed in patients with pulmonary arterial hypertension (PAH) at intermediate risk switching to riociguat versus continuing phosphodiesterase-5 inhibitors (PDE5i). This post hoc study applied the Registry to Evaluate Early and Long-Term PAH Disease Management (REVEAL) Lite 2 and Comparative Prospective Registry of Newly Initiated Therapies for Pulmonary (COMPERA) 2.0 risk-assessment tools to REPLACE to investigate the impact of baseline risk status on clinical improvement. The proportions of riociguat- and PDE5i-treated patients achieving the primary end-point at REVEAL Lite 2 low, intermediate, and high baseline risk reflected the overall population. Proportions of riociguat-treated patients achieving the primary end-point were comparable between the COMPERA 2.0 intermediate-low risk (39%) and intermediate-high risk (43%) groups. Our findings show that patients in REPLACE achieved clinical improvement by switching from PDE5i to riociguat across all COMPERA 2.0 and most REVEAL Lite 2 baseline risk strata

A reproduction of the Milky Way’s Faraday rotation measure map in galaxy simulations from global to local scales

Magnetic fields are of critical importance for our understanding of the origin and long-term evolution of the Milky Way. This is due to their decisive role in the dynamical evolution of the interstellar medium and their influence on the star-formation process1–3. Faraday rotation measures along many different sightlines across the Galaxy are a primary means to infer the magnetic field topology and strength from observations4–7. However, the interpretation of the data has been hampered by the failure of previous attempts to explain the observations in theoretical models and to synthesize a realistic multiscale all-sky rotation measures map8–10. We here utilize a cosmological magnetohydrodynamic simulation of the formation of the Milky Way, augment it with a new star-cluster population-synthesis model for a more realistic structure of the local interstellar medium11,12, and perform detailed polarized radiative transfer calculations on the resulting model13. This yields an accurate first-principles prediction of the Faraday sky as observed on Earth. The results reproduce the observations of the Galaxy not only on global scales but also on local scales of individual star-forming clouds. They also indicate that the Local Bubble14 containing our Sun dominates the rotation measures signal over large regions of the sky. Modern cosmological magnetohydrodynamic simulations of the Milky Way’s formation, combined with a plausible model for star formation, stellar feedback and the distribution of free electrons in the interstellar medium, explain the rotation measures observations remarkably well, and thus contribute to a better understanding of the origin of magnetic fields in our Galaxy

Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung

<p>Abstract</p> <p>Background</p> <p>Claudins are the main components of tight junctions, structures which are associated with cell polarity and permeability. The aim of this study was to analyze the expression of claudins 1, 3, 4, 5, and 7 in developing human lung tissues from 12 to 40 weeks of gestation.</p> <p>Methods</p> <p>47 cases were analyzed by immunohistochemisty for claudins 1, 3, 4, 5 and 7. 23 cases were also investigated by quantitative RT-PCR for claudin-1, -3 and -4.</p> <p>Results</p> <p>Claudin-1 was expressed in epithelium of bronchi and large bronchioles from week 12 onwards but it was not detected in epithelium of developing alveoli. Claudin-3, -4 and -7 were strongly expressed in bronchial epithelium from week 12 to week 40, and they were also expressed in alveoli from week 16 to week 40. Claudin-5 was expressed strongly during all periods in endothelial cells. It was expressed also in epithelium of bronchi from week 12 to week 40, and in alveoli during the canalicular period. RT-PCR analyses revealed detectable amounts of RNAs for claudins 1, 3 and 4 in all cases studied.</p> <p>Conclusion</p> <p>Claudin-1, -3, -4, -5, and -7 are expressed in developing human lung from week 12 to week 40 with distinct locations and in divergent quantities. The expression of claudin-1 was restricted to the bronchial epithelium, whereas claudin-3, -4 and -7 were positive also in alveolar epithelium as well as in the bronchial epithelium. All claudins studied are linked to the development of airways, whereas claudin-3, -4, -5 and -7, but not claudin-1, are involved in the development of acinus and the differentiation of alveolar epithelial cells.</p