Christopher Columbus in United States Historiography: Biography as Projection

pags. 357-37

Las Ordenanzas del Ayuntamiento de Ciudad Real en 1632: Retrato de una ciudad en las llanuras

Las Ordenanzas constituyen el conjunto normativo particular de cada municipio. A través de sus disposiciones se puede conocer de forma bastante fiel la regulación que la comunidad hace de los rasgos principales de su funcionamiento. En este caso, la publicación de un documento encontrado en la Real Academia de la Historia —unas ordenanzas del ayuntamiento de Ciudad Real de la primera mitad del siglo XVII— proporciona una interesante imagen de esta ciudad manchega en la Edad Moderna; en sus prohibiciones, normas de protección e imposiciones de penas se revelan para el lector los aspectos más característicos de la vida de la población.The Ordenanzas (By-laws) represent the statutes of each particular municipality and their regulations allow us to form quite a precise idea of the ways in which the community controlled the principal features of its activity. In this case, the publication of a document found in the Royal Academy of History (ordinances of the Town-hall of Ciudad Real in the first half of the XVIIth century) provides an interesting picture of this city of la Mancha in modem times; the prohibitions, rules of protection and orders of punishment reveal to the reader the most characteristic aspects of the life of the population

Ursinus College Alumni Journal, March 1960

President\u27s page • 1960 - A democratic president • Faith in the individual • Teachers are made • Alumni elections - watch for your ballot in April • On recruiting • Recent changes in the Education Department • Attention: Alumna at work • Lamond promoted • The liberal arts • An interview with Flora Rahn Lentz, Class of 1889 • Esso grant • Summer Assembly • Dr. Lentz is dead • Dr. Rice publishes new Swedish text • Dr. Stein resigns • Medical college award • Washington regional • Lehigh Valley regional • New York City regional • Philadelphia regional • South Jersey regional • Schuylkill Valley regional • Ursinus Women\u27s Club • Facts concerning the directory • Alumnae hockeyites honored • New football coach • Fall sports\u27 record • Wrestling results • Please help us • Basketball review • New look in track facilities • Track • Vanishing crafts and their craftsmen • January 1960: Mid year report of the Loyalty Fund campaign • 1960 Loyalty Fund campaign • Alvin Weiss: Man of the year • News about ourselves • Weddings • Births • Necrology • Alumni Day Saturday, June 4, 1960https://digitalcommons.ursinus.edu/alumnijournal/1068/thumbnail.jp

Interventions for preventing oral mucositis for patients with cancer receiving treatment

Interventions for preventing oral mucositis for patients with cancer receiving treatmentTreatment for cancer (including bone marrow transplant) can cause oral mucositis (severe ulcers in the mouth). This painful condition can cause difficulties in eating, drinking and swallowing, and may also be associated with infections which may require the patient to stay longer in hospital. Different strategies are used to try and prevent this condition, and the review of trials found that some of these are effective. Two interventions, cryotherapy (ice chips) and keratinocyte growth factor (palifermin®) showed some benefit in preventing mucositis. Sucralfate is effective in reducing the severity of mucositis, and a further seven interventions, aloe vera, amifostine, intravenous glutamine, granulocyte‐colony stimulating factor (G‐CSF), honey, laser and antibiotic lozenges containing polymixin/tobramycin/amphotericin (PTA) showed weaker evidence of benefit. These were evaluated in patients with different types of cancer, undergoing different types of cancer treatment. Benefits may be restricted to the disease and treatment combinations evaluated

The Determinants of International Migration in Early Modern Europe: Evidence from the Maritime Sector, c. 1700–1800

This paper offers the first multivariate regression study of international migration in earlymodern Europe. Using unique eighteenth-century data about maritime workers, we created adata set of migration flows among European countries to examine the role of factors related togeography, population, language, the market and chain migration in explaining the migrationof these workers across countries. We show that among all factors considered in ourmultivariate analysis, the geographical characteristics of the destination countries, size of porttowns, and past migrations are among the most robust and quantitatively the most importantfactors influencing cross-country migration flows

Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor

The multifunctional signaling protein p75 neurotrophin receptor (p75NTR) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP) of p75NTR is required for p75NTR-mediated glioma invasion, and identify a previously unnamed process for targeted glioma therapy. Expression of cleavage-resistant chimeras of p75NTR or treatment of animals bearing p75NTR-positive intracranial tumors with clinically applicable γ-secretase inhibitors resulted in dramatically decreased glioma invasion and prolonged survival. Importantly, proteolytic processing of p75NTR was observed in p75NTR-positive patient tumor specimens and brain tumor initiating cells. This work highlights the importance of p75NTR as a therapeutic target, suggesting that γ-secretase inhibitors may have direct clinical application for the treatment of malignant glioma

A global model of tropospheric chlorine chemistry : Organic versus inorganic sources and impact on methane oxidation

Chlorine atoms (Cl) are highly reactive toward hydrocarbons in the Earth’s troposphere, including the greenhouse gas methane (CH4). However, the regional and global CH4 sink from Cl is poorly quantified as tropospheric Cl concentrations ([Cl]) are uncertain by ~2 orders of magnitude. Here we describe the addition of a detailed tropospheric chlorine scheme to the TOMCAT chemical transport model. The model includes several sources of tropospheric inorganic chlorine (Cly), including (i) the oxidation of chlorocarbons of natural (CH3Cl, CHBr2Cl, CH2BrCl, and CHBrCl2) and anthropogenic (CH2Cl2, CHCl3, C2Cl4, C2HCl3, and CH2ClCH2Cl) origin and (ii) sea-salt aerosol dechlorination. Simulations were performed to quantify tropospheric [Cl], with a focus on the marine boundary layer, and quantify the global significance of Cl atom CH4 oxidation. In agreement with observations, simulated surface levels of hydrogen chloride (HCl), the most abundant Cly reservoir, reach several parts per billion (ppb) over polluted coastal/continental regions, with sub-ppb levels typical in more remote regions. Modeled annual mean surface [Cl] exhibits large spatial variability with the largest levels, typically in the range of 1-5×104 atoms cm-3, in the polluted northern hemisphere. Chlorocarbon oxidation provides a tropospheric Cly source of up to ~4320 Gg Cl/yr, sustaining a background surface [Cl] of 20% of total boundary layer CH4 oxidation in some locations