Mission adaptive wing soars at NASA Facility

Research pilots have flown the Mission Adaptive Wing (MAW) aircraft, a highly modified F-111 jet fighter, from subsonic speeds up to Mach 1.4 in initial flight tests. The inital test flights are clearing the envelope with the wings flexed at various curvatures. This process allows further research data to be safely gathered so that designers of future variable camber wing aircraft have the best information possible. The altitude envelope was cleared from 27,500 down to 7,500 feet where denser air can cause more stress on the aircraft. Testing with the aircraft was conducted with wing sweep angles of 26 and 58 degrees. At the conclusion of the performance tests in the manual configuration, the system will be reconfigured for automatic mode tests. The limited automatic modes include maneuver camber control where the wings are deflected automatically to the best lift versus drag combination for a particular speed; cruise camber control which can help protect the aircraft from high G stresses; and maneuver enhancement/gust alleviation which is designed to improve the aircraft's up and down movement response to pilot commands and reduce the aircraft response to turbulence

The performance of the EU-Rotate_N model in predicting the growth and nitrogen uptake of rotations of field vegetable crops in a Mediterranean environment

The EU-Rotate_N model was developed as a tool to estimate the growth and nitrogen (N) uptake of vegetable crop rotations across a wide range of European climatic conditions and to assess the economic and environmental consequences of alternative management strategies. The model has been evaluated under field conditions in Germany and Norway and under greenhouse conditions in China. The present work evaluated the model using Italian data to evaluate its performance in a warm and dry environment. Data were collected from four 2-year field rotations, which included lettuce (Lactuca sativa L.), fennel (Foeniculum vulgare Mill.), spinach (Spinacia oleracea L.), broccoli (Brassica oleracea L. var. italica Plenck) and white cabbage (B. oleracea convar. capitata var. alba L.); each rotation used three different rates of N fertilizer (average recommended N1, assumed farmer's practice N2=N1+0·3×N1 and a zero control N0). Although the model was not calibrated prior to running the simulations, results for above-ground dry matter biomass, crop residue biomass, crop N concentration and crop N uptake were promising. However, soil mineral N predictions to 0·6 m depth were poor. The main problem with the prediction of the test variables was the poor ability to capture N mineralization in some autumn periods and an inappropriate parameterization of fennel. In conclusion, the model performed well, giving results comparable with other bio-physical process simulation models, but for more complex crop rotations. The model has the potential for application in Mediterranean environments for field vegetable production

Cohomology of Line Bundles: A Computational Algorithm

We present an algorithm for computing line bundle valued cohomology classes over toric varieties. This is the basic starting point for computing massless modes in both heterotic and Type IIB/F-theory compactifications, where the manifolds of interest are complete intersections of hypersurfaces in toric varieties supporting additional vector bundles.Comment: 11 pages, 1 figure, 2 tables; v2: typos and references corrected; v3: proof-related statements updated, cohomCalg implementation available at http://wwwth.mppmu.mpg.de/members/blumenha/cohomcalg

Development and critical evaluation of a generic 2-D agro-hydrological model (SMCR_N) for the responses of crop yield and nitrogen composition to nitrogen fertilizer

Models play an important role in optimizing fertilizer use in agriculture to maintain sustainable crop production and to minimize the risk to the environment. In this study, we present a new Simulation Model for Crop Response to Nitrogen fertilizer (SMCR_N). The SMCR_N model, based on the recently developed model EU-Rotate_N for the N-economies of a wide range of crops and cropping systems, includes new modules for the estimation of N in the roots and an associated treatment of the recovery of soil mineral N by crops, for the reduction of growth rates by excessive fertilizer-N, and for the N mineralization from soil organic matter. The validity of the model was tested against the results from 32 multi-level fertilizer experiments on 16 different crop species. For this exercise none of the coefficients or parameters in the model was adjusted to improve the agreement between measurement and simulation. Over the practical range of fertilizer-N levels model predictions were, with few exceptions, in good agreement with measurements of crop dry weight (excluding fibrous roots) and its %N. The model considered that the entire reduction of soil inorganic N during growth was due to the sum of nitrate leaching, retention of N in fibrous roots and N uptake by the rest of the plant. The good agreement between the measured and simulated uptakes suggests that in this arable soil, losses of N from other soil processes were small. At high levels of fertilizer-N yields were dominated by the negative osmotic effect of fertilizer-N and model predictions for some crops were poor. However, the predictions were significantly improved by using a different value for the coefficient defining the osmotic effect for saline sensitive crops. The developed model SMCR_N uses generally readily available inputs, and is more mechanistic than most agronomic models and thus has the potential to be used as a tool for optimizing fertilizer practice

Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent

Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s). Most studies into virus entry have used cultured fibroblasts but since keratinocytes represent the primary entry site for HSV-1 infection in its human host, we initiated studies to characterize the entry pathway of HSV-1 into human keratinocytes. Electron microscopy studies visualized free capsids in the cytoplasm and enveloped virus particles in vesicles suggesting viral uptake both by direct fusion at the plasma membrane and by endocytic vesicles. The ratio of the two entry modes differed in primary human keratinocytes and in the keratinocyte cell line HaCaT. Inhibitor studies further support a role for endocytosis during HSV-1 entry. Infection was inhibited by the cholesterol-sequestering drug methyl-beta-cyclodextrin, which demonstrates the requirement for host cholesterol during virus entry. Since the dynamin-specific inhibitor dynasore and overexpression of a dominant-negative dynamin mutant blocked infection, we conclude that the entry pathways into keratinocytes are dynamin-mediated. Electron microscopy studies confirmed that virus uptake is completely blocked when the GTPase activity of dynamin is inhibited. Ex vivo infection of murine epidermis that was treated with dynasore further supports the essential role of dynamin during entry into the epithelium. Thus, we conclude that HSV-1 can enter human keratinocytes by alternative entry pathways that require dynamin and host cholesterol

Maternal fluoxetine exposure alters cortical hemodynamic and calcium response of offspring to somatosensory stimuli

Epidemiological studies have found an increased incidence of neurodevelopmental disorders in populations prenatally exposed to selective serotonin reuptake inhibitors (SSRIs). Optical imaging provides a minimally invasive way to determine if perinatal SSRI exposure has long-term effects on cortical function. Herein we probed the functional neuroimaging effects of perinatal SSRI exposure in a fluoxetine (FLX)-exposed mouse model. While resting-state homotopic contralateral functional connectivity was unperturbed, the evoked cortical response to forepaw stimulation was altered in FLX mice. The stimulated cortex showed decreased activity for FLX versus controls, by both hemodynamic responses [oxyhemoglobin (Hb

Christopher Columbus in United States Historiography: Biography as Projection

pags. 357-37

Marine boundary layer over the subtropical southeast Pacific during VOCALS-REx – Part 2: Synoptic variability

This is the publisher's version, also available electronically from http://www.atmos-chem-phys.net/10/4507/2010/acp-10-4507-2010.htmlIn the second part of this work we study the day-to-day variability of the marine atmospheric boundary layer (MBL) over the subtropical southeast Pacific using primarily results from a numerical simulation that covered the whole VOCALS-REx period (October–November 2008). In situ and satellite-derived observations of the MBL height in the offshore region indicate rapid, significant variations (from 500 m to 1700 m a.s.l. over a few days) during October. These MBL changes are connected with the passage of midlatitude troughs that altered the large-scale environment over the VOCALS-REx region. In contrast, the synoptic forcing and MBL changes were less prominent during November. Modelled and observed MBL depth at Point Omega (20° S, 85° W) compare quite well during October (but the simulation is on average 200 m lower) while in November the simulation does not perform as well. In the prognostic local MBL height equation the height change, the horizontal MBL height advection, and the large scale vertical velocity at MBL top are calculated explicitly from the simulation. The entrainment velocity is calculated as the residual of the other terms in the equation. While the vertical velocity and residual terms are opposing and generally have the largest magnitude on average, it is the variability in the advection that explains most of the large changes in the MBL depth. Examination of several cases during VOCALS-REx suggests that the advective term is in turn largely controlled by changes in wind direction, driven by midlatitude activity, acting on a MBL that generally slopes down toward the coast. In one phase, the subtropical anticyclone is reinforced and extends toward the Chilean coast, leading to easterly wind that advects low MBL heights from the coast as far as Point Omega. The opposite phase occurs after the passage of an extratropical cyclone over southern Chile, leading to southwesterly wind that advects a deeper MBL towards subtropical latitudes

Marine boundary layer over the subtropical southeast Pacific during VOCALS-REx – Part 1: Mean structure and diurnal cycle

This is the publisher's version, also available electronically from http://www.atmos-chem-phys.net/10/4491/2010/acp-10-4491-2010.html.Atmospheric subsidence over the subtropical southeast Pacific (SEP) leads to a low-level anticyclonic circulation, a cool sea surface and a cloud-topped marine boundary layer (MBL). Observations in this region from a major field campaign during October and November 2008, the VOCALS Regional Experiment, provide ample data to characterize the lower atmospheric features over the SEP. The observations are also useful to test the ability of an area-limited, high-resolution atmospheric model to simulate the SEP conditions. Observations and model-results (where appropriate) improve the characterization of the mean state (Part 1) and variability (Part 2) of the lower troposphere including circulation, MBL characteristics and the upsidence wave. Along 20° S the MBL is generally deeper offshore (1600 m at 85° W) but there is also considerable variability. MBL depth and variability decrease towards the coast and maximum inversion strength is detected between 74–76° W. Weather Research and Forecasting (WRF) simulations underestimate MBL height the most near the coast but improve offshore. Southeasterly trades prevail within the MBL although the wind speed decreases toward the coast. Above the MBL along the coast of Chile, flow is northerly, has a maximum at 3 km, and extends westward to ~74° W, apparently due to the mechanical blocking exerted by the Andes upon the westerly flow aloft. Mean MBL features along northern Chile (18–25° S) are remarkably similar (e.g., MBL depth just below 1 km) in spite of different SST. Observed diurnal cycles of the temperature at the coast and further offshore exhibit a number of conspicuous features that are consistent with the southwestward propagation of an upsidence wave initiated during late evening along the south Peru coast. Furthermore, the passage of the vertical motion results in either constructive or deconstructive interference with the radiatively-forced diurnal cycle of MBL depth. Interference is clearly seen in the soundings at Iquique which are driven by a strong upsidence wave contrary to the radiation-driven cycle, leading to a diurnal cycle opposite of the other sites. Because WRF simulations have a lower MBL height, the speed of the simulated gravity wave is slower than observations and accounts for most of the discrepancy between observed and simulated phase speeds

The Emperor’s New Clothes: How the Judicial System and the Housing-Mortgage Market Have Turned a Blind Eye to the Destruction of the Negotiability of Mortgage Promissory Notes

This Article examines the common notions of negotiable instruments as they relate to the modern day promissory note in the context of residential mortgage lending. The Article further addresses the destruction of the negotiability of such promissory notes through various undertakings added for the benefit of the banking industry, often to the detriment of a borrower. The use of negotiable instruments commenced in the 1800s in England as a way of ensuring a fluid market between trades as there was no fiat currency system in place. The fundamental purpose behind the concept of negotiability was subsequently abrogated by the modernization of the financial industry, and the creation of a global marketplace for the purchase and sale of promissory notes. Furthermore, the Article discusses how the holder in due course doctrine, which limits a borrower’s defenses when a promissory note has been transferred from one note holder to another, has created significant abuse to consumers by the financial industry. The abuse of consumers through the holder in due course doctrine remains a problem unchecked by many courts that continue to apply negotiability law to modern day promissory notes in real estate mortgage transactions despite the fact that modern day promissory notes lack any of the tenets of “negotiability” under article 3 of the Uniform Commercial Code. The Article then calls on the judiciary, as theoretically the least political and most impartial branch of government, to find that such promissory notes are no longer negotiable instruments, and therefore must be transferred via assignment pursuant to article 9 of the Uniform Commercial Code. Such a new construct or approach would provide the transparency necessary to protect consumers and preserve defenses to predatory lending by the financial industry