Derivation of dual horizon state-based peridynamics formulation based on euler-lagrange equation

The numerical solution of peridynamics equations is usually done by using uniform spatial discretisation. Although implementation of uniform discretisation is straightforward, it can increase computational time significantly for certain problems. Instead, non-uniform discretisation can be utilised and different discretisation sizes can be used at different parts of the solution domain. Moreover, the peridynamic length scale parameter, horizon, can also vary throughout the solution domain. Such a scenario requires extra attention since conservation laws must be satisfied. To deal with these issues, dual-horizon peridynamics was introduced so that both non-uniform discretisation and variable horizon sizes can be utilised. In this study, dual-horizon peridynamics formulation is derived by using Euler–Lagrange equation for state-based peridynamics. Moreover, application of boundary conditions and determination of surface correction factors are also explained. Finally, the current formulation is verified by considering two benchmark problems including plate under tension and vibration of a plate

Computational Homogenization of Architectured Materials

Architectured materials involve geometrically engineered distributions of microstructural phases at a scale comparable to the scale of the component, thus calling for new models in order to determine the effective properties of materials. The present chapter aims at providing such models, in the case of mechanical properties. As a matter of fact, one engineering challenge is to predict the effective properties of such materials; computational homogenization using finite element analysis is a powerful tool to do so. Homogenized behavior of architectured materials can thus be used in large structural computations, hence enabling the dissemination of architectured materials in the industry. Furthermore, computational homogenization is the basis for computational topology optimization which will give rise to the next generation of architectured materials. This chapter covers the computational homogenization of periodic architectured materials in elasticity and plasticity, as well as the homogenization and representativity of random architectured materials

Phytochemical composition and antioxidant activities of different aerial parts extracts of Ferula communis L.

The present study aimed to assess antioxidant activities of three organs (flower, fruit, and stem) extracts of Tunisian Ferula (F.) communis. Various experimental models were used to characterize the antioxidant activities in vitro as well as on ROS-induced fluorescence using dichlorofluorescein technique from phorbol myristate acetate (PMA)-stimulated human myeloid cell line HL-60. Results showed that the antioxidant activities varied considerably with organs. Thus, flower exhibited higher DPPH-scavenging ability, reducing and chelating power than stem and fruit. Also, antioxidant capacities using ORAC method and a cell-based assay showed that fruit and stem exhibited statistically similar antioxidant activities. Moreover, F. communis contains high amounts of flavonoids with various health benefits attributed to their antioxidant potential. Likewise, to obtain biologically relevant information, the antioxidant activities of the extracts were evaluated on cellular models implicating the antioxidant activities; this test generally showed that F. communis flower extracts have the highest antioxidant capacities correlated to the highest total phenolic content. The identification of phenolic compounds in F. communis extracts using RP-HPLC revealed that resorcinol, ferulic, and syringic acids together with coumarin were the major molecules. © 2018 Società Botanica Italian

Nutritional and health benefits of essential oils in dairy cows

International audienceScientific data supporting the efficacy of Essential oils (EOs) in livestock as anti-inflammatory, antibacterial and antioxidant molecules accumulate over time; however, the cumulative evidence is not always sufficient. Still, so far, the MILKQUA project is the first to evaluate, by a combined OMICS approach, the possible use of selected EOs in the nutrition sector and forthe treatment of mastitis in dairy cows. Given the importance of the DOHaD concept (Developmental Origin of Health and Diseases), we emphasized EOs’ impact, when included in calves’ diet, on food efficiency and animal growth. We also tested EOs direct curative effects on inflamed mammary gland and isolated Blood Mononuclear Peripheral cells (PBMC). We also assessed the in vitro ruminal fermentation and change in the microbiome content in the presence of both natural and synthetic EOs compounds and decrypted, using several in vitro models, the EOs mechanism of action on the NfKB inflammatory pathway. We present in this communication the results of our interdisciplinary approach