A Research Study in the Synthesis and the Applications of Coumarin Derivatives

Many organic and medicinal chemists are interested in the coumarin compounds because of their potential for use in pharmaceuticals and other industries. Coumarin compounds are a significant class of biologically active chemicals. Here, we outline the steps for producing coumarin derivatives quickly and effectively from commercially accessible substrates via multicomponent condensation processes involving pyrone and benzene derivatives. These substances were examined for their potential anti-tumor effects, including their ability to block carbonic anhydrase, activate the cell apoptosis protein, and coumarin and its derivatives are the primary oral anticoagulants. Candida albicans, Aspergillus fumigatus, and Fusarium solani are three distinct fungus species that are resistant to the antifungal properties of synthetic coumarins. Long known are the coumarins' antibacterial, antifilarial, antiulcerogenic, anti-inflammatory, and antioxidant effects. Coumarin has long been valued as a major raw element in the fragrance sector due to its distinct sweet aroma and stability. When mixed with organic essential oils like lavender, citrus, rosemary, and oak moss, it is used as an odour-enhancer to produce a long-lasting impact. It has been utilized as a bleaching or brightening agent in detergents. Materials such as liquid crystalline, organic/inorganic composites, as well as light harvesting, energy transferring compounds, and electro-optics materials are all employed as a dye in organic photo-redox catalysis and as potent photo-sensitizers reagent. These materials polymerize epoxy-silicones, under near-UV and visible light. Coumarin has also found useful as metal-free sensitizers for solar cells

Challenges Facing Iraq to Tackle the Spread of COVID-19: An Overview

On the 31st of December 2019, China reported several pneumonia-like infections in Wuhan's Huanan Seafood Wholesale Market. Ten days later, a novel coronavirus (2019-nCoV) was announced by the Chinese center for disease control (CCDC). At that time, the genome sequence was publicly made available. The genome sequence analysis of the newly identified virus was found similar to 75-80% of the SARS-CoV clade and more than 88% of bat corona viruses. On January 30th, the World Health Organization (WHO) declared a state of emergency due to the COVID-19 epidemic. In March 2020, the WHO raised a state of emergency and declared that COVID-19 has become a pandemic. Unfortunately, Iraq confirmed the first cases of COVID-19 in February 2020. On April 25th, 46,135 tests were conducted in Iraq with 1763 positive cases. Although Iraq is making great efforts to contain the COVID-19 pandemic stimulating all the available capabilities, such as having a full lockdown and teaching people about the sickness danger, the numbers of cases and deaths started to dramatically increase in June. Now, on the 2nd of July, the infection and death cases were around 54 K and 2.2 K, respectively. Herein, we outline the challenges that the Iraqi health sector is facing to control the spread of COVID-19 with procedures followed so far. This could assist in understanding the severity of the situation and end up with a realistic understanding of it

Synergistic antimicrobial potential: Exploring the efficacy of poly methacrylic acid (PMAA) polymers, CuO NPs, and pomegranate peel extract against bacterial pathogens

The use of agricultural and biomass waste to treat pollutants is a fruitful sector as it resolves a major problem by a low-cost and eco-friendly source. This study investigates the antimicrobial potential of Pomegranate (P. granatum) peel extract and Copper Oxide (CuO) nanoparticles (NPs), evaluating their efficacy against various bacterial strains. The P. granatum extract displayed notable bactericidal activity, particularly against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). CuO NPs induced reactive oxygen species, disrupting bacterial mechanisms and altering cellular morphology. Even at lower concentrations, both agents exhibited efficiency comparable to a higher concentration of the pharmaceutical standard (Ciprofloxacin 250 mg/10 ml, 2.5 %). These findings align with previous research, underscoring the antimicrobial properties of P. granatum and the potential of CuO NPs as alternative agents. The study highlights the significance of the ongoing quest for effective and sustainable antimicrobial solutions

Silicon-carbide (SiC) nanocrystal as technology and characterization and its applications in photo-stabilizers of Teflon

Polytetrafluoroethylene (PTFE) was mixed with silicon carbide nanoparticles in various quantities to create thin films. Long-term UV light exposure to the PTFE films was used to study the effects of SiC NPs as a photo-stabilizer by assessing changes in weight loss and surface shape. Comparing PTFE films with various SiC NP concentrations to the blank film, very little variation was seen. AFM and optical microscopy were also used to analyze the surface morphology of films. When PTFE films with additives were compared to blank film, there were hard to observe any negative changes brought due to photo-degradation. Additionally, the surfaces appeared more uniformly smooth hence SiC NPs work well as photo-stabilizers to impede photo-degradation, particularly 0.0005 gm weight. Silicon carbide nanoparticles absorb ultraviolet light, bind polymeric chains, scavenge radical moieties, and degrade peroxide residues