Comparative study of the effectiveness of intradermotherapy associated or not with microneedling and topical solution in reducing hair loss in men with androgenetic alopecia

Introduction: Androgenetic alopecia impacts patients psychologically. Androgenetic alopecia is an androgen-dependent condition characterized by hair follicles miniaturization, shortened anagen phase, and prolonged telogen phase. The increasing search for hair therapies to improve this condition leads to the need for robust methods to compare the effectiveness of treatments, such as standardized photographs and clinical evaluation. Objective: This study comparatively assessed the efficacy of intradermotherapy associated or not with microneedling and application of sterile topical solution whose active components are Octapeptide-2, Copper tripeptide-1, Chondrus crispus extract, and Silanediol salicylate. Methods: Standardized photographs and patients’ clinical findings were compared per experimental group in a blind and paired manner by dermatologists, with attribution of scores referring to hair loss improvement. Results: The group treated with the therapeutic association obtained better results than the group treated with intradermotherapy alone (control), with 70% of patients showing improvement scores against 54%. There was a statistically significant difference between the treatment groups. Conclusion: The therapeutic association of intradermotherapy with microneedling followed by topic treatment was significantly more effective in improving male hair loss compared to control