1 research outputs found
Interleukinâ10 responses from acute exercise in healthy subjects: A systematic review
Purpose: Interleukin 10 (ILâ10) is a cytokine that plays a critical role with potent antiâ
inflammatory properties when produced during exercise, limiting host immune response
to pathogens and preventing tissue damage. The purpose of this systematic review was
to assess the response of ILâ10 after acute exercise session in healthy adults.
Methods: Databases of Ovid Medline (1978â2016), CINAHL (1998â2016), EMBASE
(2003â2016), SportDiscus (1990â2016), and Web of Science library (1990â2016)
were carefully screened. Clinical trials comparing exercise types in healthy individuals
were included for pooled analysis. The trials of exercise were methodologically
appraised by PEDro Scale.
Results: Twelve randomized controlled and crossover trials containing 176
individuals were identified for inclusion. The KruskalâWallis test showed no
significant differences between type of exercise and the corresponding values in ILâ
10 [X2(4) = 2.878; p = 0.449]. The duration of exercise was significantly correlated
with increase in ILâ10 changes (Pearsonâs r = 1.00, 95%CI: 0.015â0.042, p < 0.0001)
indicating that 48% of the variation in ILâ10 levels can be explained by the duration of
the exercise performed. In addition, despite a linear increase, we did not find a
significant correlation with the intensity of exercise and ILâ10 changes (Pearsonâs
r = 0.218, 95%CI: â0.554â0.042, p < 0.035).
Conclusion: Overall, the duration of the exercise is the single most important factor
determining the magnitude of the exerciseâinduced increase of plasma ILâ10