Rezensionen

Rezension zu: 1) Dinkelaker, Jörg; Herrle, Matthias: Erziehungswissenschaftliche Videographie: eine Einführung. Wiesbaden: VS Verl. f. Sozialwissenschaften 2009. ISBN 978-3-531-16863-0. 2) Hugger, Kai-Uwe; Walber, Markus (Hg.): Digitale Lernwelten: Konzepte, Beispiele und Perspektiven. Wiesbaden: VS Verl. f. Sozialwissenschaften 2010. ISBN 978-3-531-16365-9. 3) Lenk, Christel: Freiberufler in der Weiterbildung: empirische Studie am Beispiel Hessen. Bielefeld: W. Bertelsmann Verl. 2010. ISBN 978-7639-3348-8 (Print), ISBN 978-7639-3348-5 (E-Book). 4) Merriam, Sharan B. u.a.: Non-Western Perspectives on Learning and Knowing. Malabar: Krieger Publ. Company 2007. ISBN 1-57524-280-X. 5) Meueler, Erhard: Die Türen des Käfigs: subjektorientierte Erwachsenenbildung. Baltmannsweiler: Schneider Verl. Hohengehren 2009. ISBN 978-3-8340-0527-4. 6) Neuber, Nils (Hg.): Informelles Lernen im Sport – Beiträge zur allgemeinen Bildungsdebatte. Wiesbaden: VS Verl. f. Sozialwissenschaften 2010. ISBN 978-3-531-17009-1. 7) Widany, Sarah: Lernen Erwachsener im Bildungsmonitoring: Operationalisierung der Weiterbildungsbeteiligung in empirischen Studien. Wiesbaden: VS Verl. f. Sozialwissenschaften 2009. ISBN 978-3-531-16896-8. 8) Zimmermann, Hildegard: Weiterbildung im späteren Erwerbsleben: empirische Befunde und Gestaltungsvorschläge. Bielefeld: W. Bertelsmann Verl. 2009. ISBN 978-3-7639-1132-4

PRESENÇA DE DISLIPIDEMIA E USO DE ESTATINAS EM TRABALHADORES DA AGROINDÚSTRIA E PRODUTORES RURAIS: ESTUDO PRELIMINAR

Alterações no perfil lipídico estão relacionados ao estilo de vida e comumente são tratadas com estatinas. Desta forma, esta pesquisa objetiva caracterizar trabalhadores da agroindústria e produtores rurais quanto à presença de dislipidemia e uso de estatinas, associado a variáveis demográficas. Estudo transversal e analítico, com 127 sujeitos da região do Conselho Regional de Desenvolvimento do Vale do Rio Pardo, avaliados em 2012-2013. O uso de estatinas bem como as variáveis demográficas (sexo, faixa etária, estado civil, classe econômico e escolaridade) foram obtidas por questionários. A definição da presença ou ausência de dislipidemia foi definida pelos marcadores bioquímicos, obtidos através de coleta sanguínea, após 12 horas de jejum. Os dados foram analisados com medidas de frequência e percentual, além do teste Exato de Fisher (p < 0,05). Constatou-se que 61,4% dos sujeitos eram dislipidêmicos, dos quais 89,7% não usavam estatinas. Houveram diferenças demográficas quanto a faixa etária entre aqueles que usam ou não estatinas tanto na presença de dislipidemia (p = 0,006) quanto em sua ausência (p=0,022). Verificou-se o desconhecimento e falta de controle dos níveis do perfil lipídico por alguns indivíduos

BEHAVIOR OF HEALTH INDICATORS OF RURAL WORKERS AFTER HEALTH EDUCATION ACTIONS

INTRODUCTION: In Brazil, 16 of 90 million workers perform their work activities in rural areas, which is the country's economy closely associated with rural production. However, health care provided to rural areas is less than that offered to the urban population. The diseases that affect these populations are similar, but, there is higher mortality in the rural environment. PURPOSE: This study aimed to identify the behavior of the metabolic, morphologic, and physical fitness parameters of rural workers after health education. METHODS: Metabolic, morphologic, and physical fitness parameters of seventeen rural workers were assessed. After health education, the subjects returned to the laboratory three years later and repeated the assessments. RESULTS: Reductions in metabolic variables: total cholesterol (-8.0%; p = 0.031), LDL-c (-19.1%; p = 0.005), and triglycerides (-19.1%; p = 0.044); while increases in HDL-c (18.1%; p = 0.001), resting heart rate (9.5%; p = 0.046), and body fat (14.5%; p = 0.001) also has been founded. FINAL CONSIDERATIONS: Health education promotes positive changes in the lipid profile, but not in the morphologic and physical fitness parameters of the rural workers. It is suggested that less frequent education actions can minimize health risks, contributing to improving the health of rural workers

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders

Umfeldanalyse zum Aufbau einer neuen Datenkultur in Brandenburg

Digitale Forschungsdaten gewinnen zunehmend an Bedeutung und stellen neue Herausforderungen an wissenschaftliche Einrichtungen und ihre Forschenden. Der Begriff Forschungsdatenmanagement umfasst alle Aktivitäten, die mit der Aufbereitung, Speicherung, Archivierung und Veröffentlichung von Forschungsdaten verbunden sind. Da der Umgang mit Forschungsdaten generische, fachliche, rechtliche und technische Aspekte betrifft, erfordert es eine Begleitung der Forschenden durch ein umfangreiches Spektrum an Services, von Information und Beratung bis hin zu fachspezifischen Standards und IT-Infrastrukturen. Im vorliegenden Bericht werden zunächst die Ausgangslage und die Begrifflichkeiten rund um Forschungsdatenmanagement geklärt und anschließend die wichtigsten nationalen und internationalen Strategien und Entwicklungen vorgestellt. Dabei bilden Richtlinien und Empfehlungen für Forschungsdaten(management) den Handlungsrahmen für alle Beteiligte hin zu einem nachhaltigen Forschungsdatenmanagement. Bundeslandinitiativen schaffen die Grundlage und unterstützen den Kulturwandel zu offenen Daten. Eine Forschungsdaten-Strategie für Brandenburg muss die Bedeutung von digitalen Forschungsdaten als wissenschaftliches Gut in den Vordergrund stellen, indem dafür das Bewusstsein geschaffen wird und konkrete Vorgaben und Leitlinien auf Landes- und Einrichtungsebene vereinbart werden. Gute wissenschaftliche Praxis wird durch eine geeignete Infrastruktur unterstützt, welche die heterogenen Bedarfe und Voraussetzungen aller Beteiligten berücksichtigt. Ziele sollten die Institutionalisierung von Forschungsdatenmanagement an den Hochschulen und Kooperationen zwischen den Einrichtungen Brandenburgs sein

Parâmetros bioquímicos e antropométricos de trabalhadores rurais: estudo de novas ferramentas analíticas com supervisão de técnicas padrão

Introduction: the development of chronic diseases shows a close relationship with obesity and with some biochemical markers can be considered elements of high risk for the emergence of these diseases. Aim: to verify if there is a relation between biochemical and anthropometric parameters of rural producers and to elaborate calibration models for these parameters through the Fourier Transform Infrared Spectroscopy (FT-IR). Methods: it is a cross-sectional study, which evaluated 139 rural workers, anthropometric and biochemical markers were collected. For statistical analysis, the software SPSS 20.0 was used, with Chi-square test, considering p<0.05. The data were correlated through the traditional tests with FT-IR values, using Pirouette 4.0 software. Results: the sample had a mean age of 51.65 years, predominantly female (62.6%). It was observed that subjects with altered triglycerides (TG) presented high-risk at waist circumference. The TG revealed that subjects with low risk of waist-hip ratio present desirable levels of TG. Conclusion: it is observed that overweight individuals present alterations in blood markers and through FT-IR it was possible to create calibration models for biochemical and anthropometric variables.Introdução: o desenvolvimento de doenças crônicas não transmissíveis demonstra estreita relação com a obesidade e com alguns marcadores bioquímicos podem ser considerados elementos de alto risco para o surgimento destas doenças. Objetivo: verificar se há relação entre parâmetros bioquímicos e antropométricos de produtores rurais e elaborar modelos de calibração para estes parâmetros através da Espectroscopia no Infravermelho com Transformada de Fourier (FT-IR). Materiais e métodos: trata-se de um estudo transversal, que avaliou 139 produtores rurais, foram coletados marcadores antropométricos e bioquímicos. Para estatística utilizou-se o programa SPSS 20.0, com teste de Qui-quadrado, considerando p<0,05. Foram correlacionados os dados através dos testes tradicionais com valores da FT-IR utilizando o software Pirouette 4.0. Resultados: a amostra apresentou média de idade de 51,65 anos, com predominância do sexo feminino (62,6%). Observou-se que os sujeitos com triglicerídeos (TG) alterado apresentam circunferência da cintura de alto risco. O TG revelou que sujeitos com risco baixo da relação cintura-quadril apresentam níveis desejáveis de TG. Conclusão: observa-se que pessoas com excesso de peso apresentam alterações em marcadores sanguíneos e através da FT-IR foi possível criar modelos de calibração para variáveis bioquímicas e antropométricas

CCDC 1410014: Experimental Crystal Structure Determination

ZAFXOW : bis(cycloocta-1,5-diene)-silver tetrakis(1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-olato)-aluminium Space Group: P 21/n (14), Cell: a 19.2674(8)Å b 13.2060(6)Å c 19.3368(8)Å, α 90° β 117.617(2)° γ 90° Related Article: Miriam M. Schwab, Daniel Himmel, Sylwia Kacprzak, Daniel Kratzert, Valentin Radtke, Philippe Weis, Kallol Ray, Ernst-Wilhelm Scheidt, Wolfgang Scherer, Bas de Bruin, Stefan Weber, Ingo Krossing|2015|Angew.Chem.,Int.Ed.|54|14706|doi:10.1002/anie.201506475,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

CCDC 1410013: Experimental Crystal Structure Determination

ZAFXIQ : bis(cycloocta-1,5-diene)-nickel tetrakis(1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-olato)-aluminium Space Group: P 21/c (14), Cell: a 15.8780(10)Å b 13.5248(8)Å c 19.7355(12)Å, α 90° β 90.102(3)° γ 90° Related Article: Miriam M. Schwab, Daniel Himmel, Sylwia Kacprzak, Daniel Kratzert, Valentin Radtke, Philippe Weis, Kallol Ray, Ernst-Wilhelm Scheidt, Wolfgang Scherer, Bas de Bruin, Stefan Weber, Ingo Krossing|2015|Angew.Chem.,Int.Ed.|54|14706|doi:10.1002/anie.201506475,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

CCDC 1410015: Experimental Crystal Structure Determination

ZAFXUC : bis(cycloocta-1,5-diene)-rhodium tetrakis(1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-olato)-aluminium Space Group: P 21/n (14), Cell: a 13.6555(9)Å b 19.7888(14)Å c 15.7109(11)Å, α 90° β 92.257(2)° γ 90° Related Article: Miriam M. Schwab, Daniel Himmel, Sylwia Kacprzak, Daniel Kratzert, Valentin Radtke, Philippe Weis, Kallol Ray, Ernst-Wilhelm Scheidt, Wolfgang Scherer, Bas de Bruin, Stefan Weber, Ingo Krossing|2015|Angew.Chem.,Int.Ed.|54|14706|doi:10.1002/anie.201506475,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.