Virtual-bike emulation in a series-parallel human-powered electric bike

Combining the advantages of standard bicycles and electrified vehicles, electric bikes (e-Bikes) are promising vehicles to reduce emission and traffic. The current literature on e-Bikes ranges from works on the energy management to the vehicle control to properly govern the human-vehicle interaction. This last point is fundamental in chain-less series bikes, where the link between the human and the vehicle behavior is only given by a control law. In this work, we address this problem in a series-parallel bike. In particular, we provide an extension of the virtual-chain concept, born for series bikes, and then we improve it developing a virtual-bike framework. Experimental results are used to validate the effectiveness of the solutions, when the cyclist is actually riding the bike.Comment: Accepted for publication at the IFAC World Congress 202

Non-Invasive Experimental Identification of a Single Particle Model for LiFePO4 Cells

The rapid spread of Lithium-ions batteries (LiBs) for electric vehicles calls for the development of accurate physical models for Battery Management Systems (BMSs). In this work, the electrochemical Single Particle Model (SPM) for a high-power LiFePO4 cell is experimentally identified through a set of non-invasive tests (based on voltage-current measurements only). The SPM is identified through a two-step procedure in which the equilibrium potentials and the kinetics parameters are characterized sequentially. The proposed identification procedure is specifically tuned for LiFePO4 chemistry, which is particularly challenging to model due to the non-linearity of its open circuit voltage (OCV) characteristic. The identified SPM is compared with a second-order Equivalent Circuit Model (ECM) with State of Charge dependency. Models performance is compared on dynamic current profiles. They exhibit similar performance when discharge currents peak up to 1C (RMSE between simulation and measures smaller than 20 mV) while, increasing the discharge peaks up to 3C, ECM's performance significantly deteriorates while SPM maintains acceptable RMSE (< 50 mV).Comment: Accepted for publication at the IFAC World Congress 202

An Add-on Model Predictive Control Strategy for the Energy Management of Hybrid Electric Tractors

The hybridization process has recently touched also the world of agricultural vehicles. Within this context, we develop an Energy Management Strategy (EMS) aiming at optimizing fuel consumption, while maintaining the battery state of charge. A typical feature of agricultural machines is that their internal combustion engine is speed controlled, tracking the reference requested by the driver. In view of avoiding any modification on this original control loop, an add-on EMS strategy is proposed. In particular, we employ a multi-objective Model Predictive Control (MPC), taking into account the fuel consumption minimization and the speed tracking requirement, including the engine speed controller in the predictive model. The proposed MPC is tested in an experimentally-validated simulation environment, representative of an orchard vineyard tractor.Comment: Submitted to IEEE Transactions on Vehicular Technolog

Effect of a quality improvement program on compliance to the sepsis bundle in non-ICU patients: a multicenter prospective before and after cohort study

ObjectiveSepsis and septic shock are major challenges and economic burdens to healthcare, impacting millions of people globally and representing significant causes of mortality. Recently, a large number of quality improvement programs focused on sepsis resuscitation bundles have been instituted worldwide. These educational initiatives have been shown to be associated with improvements in clinical outcomes. We aimed to evaluate the impact of a multi-faceted quality implementing program (QIP) on the compliance of a “simplified 1-h bundle” (Sepsis 6) and hospital mortality of severe sepsis and septic shock patients out of the intensive care unit (ICU).MethodsEmergency departments (EDs) and medical wards (MWs) of 12 academic and non-academic hospitals in the Lombardy region (Northern Italy) were involved in a multi-faceted QIP, which included educational and organizational interventions. Patients with a clinical diagnosis of severe sepsis or septic shock according to the Sepsis-2 criteria were enrolled in two different periods: from May 2011 to November 2011 (before-QIP cohort) and from August 2012 to June 2013 (after-QIP cohort).Measurements and main resultsThe effect of QIP on bundle compliance and hospital mortality was evaluated in a before–after analysis. We enrolled 467 patients in the before-QIP group and 656 in the after-QIP group. At the time of enrollment, septic shock was diagnosed in 50% of patients, similarly between the two periods. In the after-QIP group, we observed increased compliance to the “simplified rapid (1 h) intervention bundle” (the Sepsis 6 bundle – S6) at three time-points evaluated (1 h, 13.7 to 18.7%, p = 0.018, 3 h, 37.1 to 48.0%, p = 0.013, overall study period, 46.2 to 57.9%, p &lt; 0.001). We then analyzed compliance with S6 and hospital mortality in the before- and after-QIP periods, stratifying the two patients’ cohorts by admission characteristics. Adherence to the S6 bundle was increased in patients with severe sepsis in the absence of shock, in patients with serum lactate &lt;4.0 mmol/L, and in patients with hypotension at the time of enrollment, regardless of the type of admission (from EDs or MWs). Subsequently, in an observational analysis, we also investigated the relation between bundle compliance and hospital mortality by logistic regression. In the after-QIP cohort, we observed a lower in-hospital mortality than that observed in the before-QIP cohort. This finding was reported in subgroups where a higher adherence to the S6 bundle in the after-QIP period was found. After adjustment for confounders, the QIP appeared to be independently associated with a significant improvement in hospital mortality. Among the single S6 procedures applied within the first hour of sepsis diagnosis, compliance with blood culture and antibiotic therapy appeared significantly associated with reduced in-hospital mortality.ConclusionA multi-faceted QIP aimed at promoting an early simplified bundle of care for the management of septic patients out of the ICU was associated with improved compliance with sepsis bundles and lower in-hospital mortality

Virtual-bike emulation in a series-parallel human-powered electric bike

Combining the advantages of standard bicycles and electrified vehicles, electric bikes (e-Bikes) are promising vehicles to reduce emission and traffic. The current literature on e-Bikes ranges from works on the energy management to the vehicle control to properly govern the human-vehicle interaction. This last point is fundamental in chain-less series bikes, where the link between the human and the vehicle behavior is only given by a control law. In this work, we address this problem in a series-parallel bike. In particular, we provide an extension of the virtual-chain concept, born for series bikes, and then we improve it developing a virtual-bike framework. Experimental results are used to validate the effectiveness of the solutions, when the cyclist is actually riding the bike.Comment: Accepted for publication at the IFAC World Congress 202

Combined delivery of bone marrow-derived mononuclear cells in chronic ischemic heart disease: rationale and study design

BACKGROUND: Treatment with bone marrow-derived mononuclear cells (BM-MNC) may improve left ventricular (LV) function in patients with chronic ischemic heart disease (IHD). Delivery method of the cell product may be crucial for efficacy. HYPOTHESIS: We aimed to demonstrate that the combination of intramyocardial and intracoronary injection of BM-MNC is safe and improves LV function in patients with chronic IHD. METHODS: After a safety/feasibility phase of 10 patients, 54 patients will be randomly assigned in a 1:1:1 pattern to 1 control and 2 BM-MNC treatment groups. The control group will be treated with state-of-the-art medical management. The treatment groups will receive either exclusively intramyocardial injection or a combination of intramyocardial and intracoronary injection of autologous BM-MNC. Left ventricular function as well as scar size, transmural extension, and regional wall-motion score will be assessed by cardiac magnetic resonance imaging studies at baseline and after 6 months. The primary endpoint is the change in global LV ejection fraction by cardiac magnetic resonance from 6 months to baseline. RESULTS: The results, it is hoped, will have important clinical impact and provide essential information to improve the design of future regenerative-medicine protocols in cardiology. CONCLUSIONS: As cell delivery may play an important role in chronic IHD, we aim to demonstrate feasibility and efficacy of a combined cell-delivery approach in patients with decreased LV function