Carpal tunnel syndrome and the "double crush" hypothesis: a review and implications for chiropractic

Upton and McComas claimed that most patients with carpal tunnel syndrome not only have compressive lesions at the wrist, but also show evidence of damage to cervical nerve roots. This "double crush" hypothesis has gained some popularity among chiropractors because it seems to provide a rationale for adjusting the cervical spine in treating carpal tunnel syndrome. Here I examine use of the concept by chiropractors, summarize findings from the literature, and critique several studies aimed at supporting or refuting the hypothesis. Although the hypothesis also has been applied to nerve compressions other than those leading to carpal tunnel syndrome, this discussion mainly examines the original application – "double crush" involving both cervical spinal nerve roots and the carpal tunnel. I consider several categories: experiments to create double crush syndrome in animals, case reports, literature reviews, and alternatives to the original hypothesis. A significant percentage of patients with carpal tunnel syndrome also have neck pain or cervical nerve root compression, but the relationship has not been definitively explained. The original hypothesis remains controversial and is probably not valid, at least for sensory disturbances, in carpal tunnel syndrome. However, even if the original hypothesis is importantly flawed, evaluation of multiple sites still may be valuable. The chiropractic profession should develop theoretical models to relate cervical dysfunction to carpal tunnel syndrome, and might incorporate some alternatives to the original hypothesis. I intend this review as a starting point for practitioners, educators, and students wishing to advance chiropractic concepts in this area

In vivo study of angiotensin II tachyphylaxis in freely moving normo- and hypertensive rats

Pharmacology and Toxicology744-5223-227PHTO

Zero waste approach towards a sustainable waste management

On 30 June 2020, young scholars presented & discussed their work in a virtual forum, as a special session organized by The 15th International Conference on Waste Management and Technology (June 28–30), 2020 Beijing China. The forum convened researchers and attendees approaching innovative aspects of waste management from a variety of perspectives and disciplines. While their presentations spanned topics as broad as the stakeholder coordination and as specific technological approach for rapid carbonization of agricultural waste, several conceptual threads could be traced across them