Importance of Nanoparticles in Cancer Therapy and Drug Delivery: A Detailed Theory and Gaps

Nanoparticles are a game-changing innovation in cancer therapy and drug delivery. Their ability to enhance drug targeting, overcome biological barriers, and minimize side effects makes them a cornerstone of modern oncology. The challenge lies in effectively distinguishing cancer cells from their regular counterparts in cancer therapy. Nanotechnology has emerged as a transformative solution, addressing this challenge through precise treatment modalities. This chapter delves into the pivotal role of Nanoparticles (NPs) in cancer therapy, primarily focusing on their significance in the drug delivery process. Overcoming the hurdles posed by conventional treatments, the genomic instability of tumors contributes to the variability among cancers, resulting in chemoresistance that challenges therapeutic success. A pioneering deep learning approach coupled with NPs has been proposed to tackle these issues, outshining previous methodologies by delivering drugs with accurate precision to target cancer cells and tissues. Through this innovative deep-learning technique, the proposed model achieves exceptional outcomes. With a remarkable accuracy of 97.591%, sensitivity of 96.644%, and specificity of 96.415%, the deep learning-enabled NPs demonstrate efficiency compared to the modern methods. This proposed model ushers in a new era of hope for patients and clinicians in the fight against cancer

A scoping review in Indian post-stroke patients

Stroke is the second most common cause of death worldwide and the third most common cause of disability-adjusted life years (DALYs) worldwide. According to the available evidence, 85.5 % of total stroke fatalities are reported in lowand middle-income countries compared with high-income countries. In addition, the prevalence of DALYs in low-income countries is very high. The major challenge is the vastness of India and its humongous population size, which makes it nearly impossible to reach patients far away. The quality of life (QoL) of stroke survivors is an important factor in predicting the burden of the disease and determining the effectiveness of treatment. Many research studies provide an overview of the overall estimates of QoL and contribute to research on QoL after stroke in India. Owing to the bleak post-stroke rehabilitation facilities in India, stroke patients don't get the post-stroke care they ought to. The gap is not only in the patient care management system but also in the policies laid out by the government. The unmet gaps in post-stroke rehabilitation and patient care remain a major setback in patient care management, which impacts the clinical outcomes at large. These challenges are the reasons for the increasing disease burden on society and the hampering of the socio-economic status of the country at large. The government authorities should lay down the policy that will help the patient seek the correct in-time treatment for stroke and help the post-stroke patients to live a QoL

HEALTH CARE SEEKING INTERVAL AND FATALITY RATE IN SWINE FLU (H1N1) EPIDEMIC IN SURAT CITY

ABSTRACT Objectives: This study was conducted to assess influence of reporting time to health care setup on fatality rate in early 2015 swine flu epidemic. Method: All Swine flu positive cases reported to Surat Municipal Corporation (SMC) from Jan to March 2015 were included in the study. Hospital records were studied retrospectively to gather desired information. Results: Incidence rate and fatality rate of swine flu was 16.38 per lac and 5.91% respectively. Mean differences of interval between onsets of symptoms to reporting to hospital is not significant, however lesser interval between onset of symptoms to swab collection and diagnosis of swine flu were significantly associated with lesser fatality. Fatality Rate declines from January to March. Conclusion: After patient report to the health care setup, prompt sample collection and quick diagnosis help to reduce fatality rate

HEALTH CARE SEEKING INTERVAL AND FATALITY RATE IN SWINE FLU (H1N1) EPIDEMIC IN SURAT CITY

ABSTRACT Objectives: This study was conducted to assess influence of reporting time to health care setup on fatality rate in early 2015 swine flu epidemic. Method: All Swine flu positive cases reported to Surat Municipal Corporation (SMC) from Jan to March 2015 were included in the study. Hospital records were studied retrospectively to gather desired information. Results: Incidence rate and fatality rate of swine flu was 16.38 per lac and 5.91% respectively. Mean differences of interval between onsets of symptoms to reporting to hospital is not significant, however lesser interval between onset of symptoms to swab collection and diagnosis of swine flu were significantly associated with lesser fatality. Fatality Rate declines from January to March. Conclusion: After patient report to the health care setup, prompt sample collection and quick diagnosis help to reduce fatality rate

Early Life Exposure to Fructose and Offspring Phenotype: Implications for Long Term Metabolic Homeostasis

The consumption of artificially sweetened processed foods, particularly high in fructose or high fructose corn syrup, has increased significantly in the past few decades. As such, interest into the long term outcomes of consuming high levels of fructose has increased significantly, particularly when the exposure is early in life. Epidemiological and experimental evidence has linked fructose consumption to the metabolic syndrome and associated comorbidities—implicating fructose as a potential factor in the obesity epidemic. Yet, despite the widespread consumption of fructose-containing foods and beverages and the rising incidence of maternal obesity, little attention has been paid to the possible adverse effects of maternal fructose consumption on the developing fetus and long term effects on offspring. In this paper we review studies investigating the effects of fructose intake on metabolic outcomes in both mother and offspring using human and experimental studies