28 research outputs found
Managing dub with progesterone - locally or orally which is a better option?
Background: The levonorgestrel intrauterine system (LNG-IUS) is a safe and effective form of contraception used by millions of people worldwide. Other than this, it has many non-contraceptive benefits-treatments for dysfunctional uterine bleeding (DUB), fibroid uterus, endometriosis and endometrial hyperplasia.Methods: A prospective longitudinal comparative study was carried out at department of obstetrics and gynaecology S.N. Medical College, Agra, Uttar Pradesh, India including 100 women of 20-45 years of age group (comparable in all aspects), with DUB. All cases were subjected to detailed history, examination and baseline investigations- Hemoglobin (Hb), endometrial aspiration, histopathology and ultrasound pelvis (along with endometrial thickness) and PBAC scoring before starting the treatment. Then cases were randomly allocated in two equal groups. In group A LNG-IUS was inserted. In group B cases were prescribed oral medroxy progesterone acetate 10 mg bd from 5th and 25th day of menstrual cycle. Cases were followed at 1 month, 3 months and 6 months after starting treatment. At each follow-up visit primary outcome in terms of subjective assessment by patient, PBAC scores and secondary outcome as Hb levels and side-effects were recorded.Results: Reduction in PBAC Scores, improvement in Hb and reduction in endometrial thickness were seen with both treatment modalities but results were significantly (p <0.0001) better with LNG-IUS group as compared to MPA. LNG-IUS was found to be more effective in endometrial hyperplasia and proliferative type of endometrium.Conclusions: LNG-IUS is a good alternative to oral progesterone therapy for patients of DUB
Seeing sharper and deeper: JWST's first glimpse of the photometric and spectroscopic properties of galaxies in the epoch of reionisation
We analyse the photometric and spectroscopic properties of four galaxies in
the epoch of reionisation (EoR) within the SMACS 0723 JWST Early Release
Observations field. Given the known spectroscopic redshifts of these sources,
we investigated the accuracy with which photometric redshifts can be derived
using NIRCam photometry alone, finding that F115W imaging is essential to
distinguish between z~8 galaxies with high equivalent width (EW) [O III]
{\lambda}5007 emission and z~10 Balmer break galaxies. We find that all four
sources exhibit strong (> 0.6 mag) F356W-F444W colours, which sit at the
extreme end of theoretical predictions from numerical simulations. We find that
these galaxies deviate (by roughly 0.5 dex) from the local correlation between
[O III] {\lambda}5007/H\beta and [Ne III] {\lambda}3869/[O II], which is
consistent with the predictions from simulations of high-redshift galaxies. We
measure the [O III] {\lambda}5007 rest-frame equivalent widths both directly
from the spectroscopy, and indirectly as inferred from the strong F356W-F444W
colours, finding large [O III] {\lambda}5007 EWs of 400-1000 {\AA}. The [O III]
{\lambda}5007 and H\beta EWs are consistent with those seen in extreme,
intensely star-forming dwarf galaxies in the local Universe. Our structural
analysis indicates that these galaxies are resolved, exhibiting irregular
shapes with bright clumps and colour gradients. In line with the predictions
from the FLARES hydrodynamic simulations, such intense star formation and
extreme nebular conditions are likely the norm, rather than the exception, in
the EoR. Finally, although star-forming galaxies and AGN often occupy similar
regions within the [O III] {\lambda}5007/H\beta-[O II]/H{\delta} plane, we find
that AGN exhibit distinct, red colours in the F150W-F200W, F200W-F277W plane.Comment: 14 pages, 8 figure
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study
The drug-induced liver injury network (DILIN) is conducting a prospective study of patients with DILI in the United States. We present characteristics and subgroup analyses from the first 1257 patients enrolled in the study
Not Available
Not AvailableStudying plant response and adaptation under low nitrogen stress condition is pre-requisite to enhance nitrogen use efficiency in crops. The present study investigated the physiological and molecular responses of maize (Zea mays L.) to nitrogen stress during early vegetative stage. Maize seedlings were grown hydroponically under controlled environmental conditions in phytotron. One set of plants were nutritionally stressed by eliminating nitrogen source in hydroponic culture while the other set was provided with nitrogen (2 mM KNO3). Under nitrogen-starvation condition, plant growth and physiological parameters changed dramatically. Significant reduction in chlorophyll content, total soluble proteins and nitrate reductase activity was observed. Further, nitrogen-starvation resulted into differential expression of genes related to nitrogen-assimilation and metabolism. The present study might be useful to improve our understanding towards plants adaptive response under nitrogen-starvation conditions.Not Availabl
Managing dub with progesterone - locally or orally which is a better option?
Background: The levonorgestrel intrauterine system (LNG-IUS) is a safe and effective form of contraception used by millions of people worldwide. Other than this, it has many non-contraceptive benefits-treatments for dysfunctional uterine bleeding (DUB), fibroid uterus, endometriosis and endometrial hyperplasia.Methods: A prospective longitudinal comparative study was carried out at department of obstetrics and gynaecology S.N. Medical College, Agra, Uttar Pradesh, India including 100 women of 20-45 years of age group (comparable in all aspects), with DUB. All cases were subjected to detailed history, examination and baseline investigations- Hemoglobin (Hb), endometrial aspiration, histopathology and ultrasound pelvis (along with endometrial thickness) and PBAC scoring before starting the treatment. Then cases were randomly allocated in two equal groups. In group A LNG-IUS was inserted. In group B cases were prescribed oral medroxy progesterone acetate 10 mg bd from 5th and 25th day of menstrual cycle. Cases were followed at 1 month, 3 months and 6 months after starting treatment. At each follow-up visit primary outcome in terms of subjective assessment by patient, PBAC scores and secondary outcome as Hb levels and side-effects were recorded.Results: Reduction in PBAC Scores, improvement in Hb and reduction in endometrial thickness were seen with both treatment modalities but results were significantly (p <0.0001) better with LNG-IUS group as compared to MPA. LNG-IUS was found to be more effective in endometrial hyperplasia and proliferative type of endometrium.Conclusions: LNG-IUS is a good alternative to oral progesterone therapy for patients of DUB
Not Available
Not Availablepost green revolution agriculture is based on generous
application of fertilizers and high-yielding genotypes that
are suited for such high input regimes. Cereals, like maize
(Zea mays L.) are capable of utilizing less than 20% of
the applied inorganic phosphate (Pi) - a non-renewable fertilizer
resource. A greater understanding of the molecular
mechanisms underlying the acquisition, transportation and
utilization of Pi may lead to engineering genotypes with
high phosphorus use efficiency. In this study, we carried
out functional domain similarity analysis, promoter analysis
and comparative transcriptional expression profiling of
12 selected Pi responsive genes in the Pi stress tolerant
maize inbred line HKI-163 under sufficient and deficient
Pi conditions. Pi starvation led to significant increase in
root length; marked proliferation of root hairs and lesser
number of crown roots. Eleven genes were significantly
up or down regulated in Pi deficient condition. The putative
acid phosphatase, ZmACP5 expression was up regulated
by 162.81 and 74.40 fold in root and leaf tissues,
respectively. The RNase, ZmRNS1 showed 115 fold up
regulation in roots under Pi deprivation. Among the two
putative high affinity Pi transporters ZmPht1;4 was found
specific to root, whereas ZmPht2 was found to be up regulated
in both root and leaf tissues. The genes involved in Pi homeostasis pathway (ZmSIZ1, SPX1 and Pho2) were
up regulated in root and leaf. In light of the expression
profiling of selected regulatory genes, an updated model
of transcriptional regulation under Pi starvation in maize
has been presented.Not Availabl
Role of ecotourism in conserving forest biomass: A mathematical model
Ecotourism is a form of tourism involving responsible travel to natural areas, conserving the environment, and improving the well-being of the local people. Its purpose may be to educate the traveler, to provide funds for ecological censervation, to directly benifit the economic development, and political empowerment of local communities. Ecotourism has come up as an important conservation strategy in the tropical areas where diversity of species and habitats are threatened because of the traditional forms of development. This study deals with a non-linear mathematical model with a novel idea for sustainable development of biomass with ecotourism which is imperative in the present scenario. Stability and bifurcation analysis of the model is done and it is observed from our study that the system predicts unstability and exhibits bifurcation if ecotourism goes beyond a threshold value
Elevated <tex>CO_{2}$</tex> improves growth and phosphorus utilization efficiency in cereal species under sub- optimal phosphorus supply
Not Available
ICAR- IIWM News, Jan.- June 2017water, energy and food security, drip irrigation, water use, carp polyculture, concerns on drought-induced recent heat waves and warm spells in IndiaICAR-Indian Institute of Water Management, Bhubaneswa