Quality evaluation of compounded capsules

The aim of this study was to evaluate the quality of compounded capsules of different drugs for chronic diseases. It were assessed two samples, from two different pharmacies, for each of the following drugs: ranitidine 150 mg, methyldopa 250 mg, enalapril maleate 20 mg, fluoxetine hydrochloride 20 mg, propranolol hydrochloride 40 mg, and furosemide 40 mg. The assays of mean weight, content determination, content uniformity and dissolution were performed according to Brazilian Pharmacopoeia. All samples were approved in the assay of mean weight, and the samples M1 and Flu1 had failed in the assay of content determination. In the test of uniformity of dosage units the samples M1, Flu1, E1, E2 and Flu2 had failed. Only the samples M2, P1, P2, F1 and F2 were accepted in all pharmacopoeial tests, evidencing that the others did not achieve the minimum requirements to ensure safety, quality and efficacy of the drugs.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Development and Validation of a Method for Simultaneous Determination of Bioactive Compounds of Tanacetum parthenium

The sesquiterpene lactones (SL), guaianolide (11,13-dehydrocompressanolide) and parthenolide (4α,5β-epoxy-germacra-1-(10),11-(13)-dien-12,6α-olide), found in Tanacetum parthenium (L.) Schultz Bip, showed in vitro significant activity against Leishmania amazonensis. In this way, a new method for the simultaneous determination of SL was developed and validated. For separation, it was employed high performance liquid chromatography coupled to photodiode array detector (HPLC Alliance e2695-2998PDA, λ 210 nm) with linear gradient of phase (A) acidified water 0.1% H3PO4 (pH 2.8) and phase (B) acetonitrile, in different proportions, at a flow rate of 1.2 mL min-1 with XBridge C8 column (4.6 × 100 mm, 3.5 µm, 35 ºC). The method showed resolution (> 1.5); selectivity, linearity (coefficient of correlation > 0.99), precision (relative standard deviation of 2.2%) and accuracy (recovery > 98%); presenting 52.55 µg mg-1 of guaianolide and 566.05 µg mg-1 of parthenolide in the dichloromethane fraction of the hydroalcoholic extract of Tanacetum parthenium. The method presents potential use in quality control and development of new phytochemicals, a promising alternative in the treatment of leishmaniasis