Primera cita en Sudamérica de tres especies alóctonas de áfidos (Hemiptera, Aphididae) recogidos en la Argentina

Three species of aphids (Hemiptera, Aphididae) are recorded for the first time in South America from specimens collected in the Argentine provinces of Mendoza, Rio Negro and San Luis: Uroleucon taraxaci (Kaltenbach, 1843) related to the adventitious plant Taraxacum officinale, and Siphonatrophia cupressi Swain, 1918 and Liosomaphis berberidis (Kaltenbach, 1843) that can affect to garden plants. Morphological data that characterize each species and other data about their biology and distribution are provided, in order to facilitate the monitoring of the possible dispersion of these aphid-species in South America.Se citan por primera vez en Sudamérica tres especies de áfidos (Hemiptera, Aphididae) a partir de colectas realizadas en las provincias argentinas de Mendoza, Río Negro y San Luis: Uroleucon taraxaci (Kaltenbach, 1843) relacionada con la adventicia Taraxacum officinale, y Siphonatrophia cupressi Swain, 1918 y Liosomaphis berberidis (Kaltenbach, 1843) que pueden afectar a plantas de jardinería. Se aportan datos morfológicos que las caracterizan y otros sobre su biología y distribución, que facilitarán el seguimiento de su posible dispersión en América del Sur

MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia

Inositol polyphosphates are vital metabolic and secondary messengers, involved in diverse cellular functions. Therefore, tight regulation of inositol polyphosphate metabolism is essential for proper cell physiology. Here, we describe an early-onset neurodegenerative syndrome caused by loss-of-function mutations in the multiple inositol-polyphosphate phosphatase 1 gene (MINPP1). Patients are found to have a distinct type of Pontocerebellar Hypoplasia with typical basal ganglia involvement on neuroimaging. We find that patient-derived and genome edited MINPP1−/− induced stem cells exhibit an inefficient neuronal differentiation combined with an increased cell death. MINPP1 deficiency results in an intracellular imbalance of the inositol polyphosphate metabolism. This metabolic defect is characterized by an accumulation of highly phosphorylated inositols, mostly inositol hexakisphosphate (IP6), detected in HEK293 cells, fibroblasts, iPSCs and differentiating neurons lacking MINPP1. In mutant cells, higher IP6 level is expected to be associated with an increased chelation of intracellular cations, such as iron or calcium, resulting in decreased levels of available ions. These data suggest the involvement of IP6-mediated chelation on Pontocerebellar Hypoplasia disease pathology and thereby highlight the critical role of MINPP1 in the regulation of human brain development and homeostasis

Pest categorisation of the Gonipterus scutellatus species complex

The Panelon Plant health performed a pest categorisation of the Australian Eucalyptus snout-beetle Gonipterusscutellatus (Coleoptera: Curculionidae), for the EU. G.scutellatus should be referred as the G.scutellatus species complex because it includes several cryptic species. A complete nomenclature of the species present in the EU is still pending. It is a quarantine pest listed in Annex IIB of Council Directive 2000/29/EC. Protected zones are in place in Greece and Portugal (Azores). In the EU, it has been found in Italy, France, Spain and Portugal. It only consumes Eucalyptus species leaves. The main pathways of spread are the trade of Eucalyptus timber, hitchhiking in various commodities, trade of apple fruit as well as of plants for planting or plant parts. Spread by flight is also possible. The climate of the EU protected zones is similar to that of the Member States (MS) where the G.scutellatus complex is established, and the pest's main host plants are present. The damaged trees suffer die-back and the development of epicormics shoots. Severe attacks may provoke massive amounts of tree death. Biological control by using the egg parasitoid wasp Anaphesnitens is the most effective control measure. Some species within the G.scutellatus complex are not yet present in the EU (including G.scutellatus sensu stricto) and might therefore be considered as potential union quarantine pests for the EU territory. At least two species within the G.scutellatus complex (most likely G.platensis and Gonipterus species no. 2) meet the criteria assessed by EFSA for consideration as potential protected zone quarantine pests for the territory of the protected zones: Greece and Portugal (Azores). The criteria for considering the G.scutellatus complex as a potential regulated non-quarantine pest for the EU are not met since plants for planting are not the main pathway

Lutte biologique a l'aide d'arthropodes

National audienc

To compare the efficacy of blood pressure reduction with or without the biochemical profile

Background - Resistant hypertension (RH) is common among adults with hypertension affecting up to 30% of patients on treatment for blood pressure (BP) control. It is predictedto increase, as old age and obesity are considered major risk factors for RH. Effective treatment of RH still remains an unmet goal of antihypertensive treatment. This thesis compared two methods of treating RH in two hospital settings, with or without the use of a biochemical blood test.Methods and Results - This was a prospective, quantitative cohort study conducted over 20 months. A total of 213 patients were recruited; 109 (100%) from site 1 (SI) and 111 (100%) from site 2 (S2). The mean age was 53.6 for S 1 and 55.1 for S 2 and there were 58 male patients from both sites (SI, 53% v S2, 52%). There were 12.9% v 18.21% smokers, 6.8 % v 15.3% diabetics, 54.1% v 79.3% hypercholesterolaemia and a family history of coronary heartdisease 61.1% v 83.3% in SI and S2 respectively. The comparison of BP control between the two groups for the study period showed 30.5% from SI and 32.5% from S2 achieved BP control. A comparison at fixed time of three, six, and nine months SI v S2 (10.5% v 16.2%, 20.0% v 22.2%, 26.3% v 23.2%) showed no statistically significant difference in BP control.Among those aged 55yrs, 22.5% at SI v 34.5% at S2 achieved BP control, Conclusion - There was no statistically significant difference in BP control between those treated on the basis of a biochemical profile or on the nationally agreed algorithm. It can be proposed that health care professionals such as specialist nurses in cardiology could play a significant role in addressing this growing problem

El control integrado en los cultivos de hortelizas protegidos de las regiones del sud de Francia. Algunos problemas de actualidad

International audienc

Aphids and their parasitoids

International audienc

To compare the efficacy of blood pressure reduction with or without the biochemical profile

Background - Resistant hypertension (RH) is common among adults with hypertension affecting up to 30% of patients on treatment for blood pressure (BP) control. It is predicted to increase, as old age and obesity are considered major risk factors for RH. Effective treatment of RH still remains an unmet goal of antihypertensive treatment. This thesis compared two methods of treating RH in two hospital settings, with or without the use of a biochemical blood test. Methods and Results - This was a prospective, quantitative cohort study conducted over 20 months. A total of 213 patients were recruited; 109 (100%) from site 1 (SI) and 111 (100%) from site 2 (S2). The mean age was 53.6 for S 1 and 55.1 for S 2 and there were 58 male patients from both sites (SI, 53% v S2, 52%). There were 12.9% v 18.21% smokers, 6.8 % v 15.3% diabetics, 54.1% v 79.3% hypercholesterolaemia and a family history of coronary heart disease 61.1% v 83.3% in SI and S2 respectively. The comparison of BP control between the two groups for the study period showed 30.5% from SI and 32.5% from S2 achieved BP control. A comparison at fixed time of three, six, and nine months SI v S2 (10.5% v 16.2%, 20.0% v 22.2%, 26.3% v 23.2%) showed no statistically significant difference in BP control. Among those aged 55yrs, 22.5% at SI v 34.5% at S2 achieved BP control, Conclusion - There was no statistically significant difference in BP control between those treated on the basis of a biochemical profile or on the nationally agreed algorithm. It can be proposed that health care professionals such as specialist nurses in cardiology could play a significant role in addressing this growing problem.EThOS - Electronic Theses Online ServiceGBUnited Kingdo