Esophageal Motility Disorders Associated With Death or Allograft Dysfunction After Lung Transplantation? Results of a Retrospective Monocentric Study

International audienc

Impact of COVID-19 pandemic on antifungal consumption: a multicenter retrospective analysis

Abstract Background In the context of COVID-19 pandemic, antifungal overuse may have occurred in our hospitals as it has been previously reported for antibacterials. Methods To investigate the impact of COVID-19 on antifungal consumption, a multicenter retrospective study including four medical sites and 14 intensive care units (ICU) was performed. Antifungal consumption and incidences of invasive fungal diseases before and during COVID-19 pandemic, for non-COVID-19 patients and COVID-19 patients, were described. Results An increase in voriconazole consumption was observed in 2020 compared with 2019 for both the whole hospital and the ICU (+ 40.3% and + 63.7%, respectively), whereas the incidence of invasive aspergillosis significantly increased in slightly lower proportions in the ICU (+ 46%). Caspofungin consumption also increased in 2020 compared to 2019 for both the whole hospital and the ICU (+ 34.9% and + 17.0%, respectively) with an increased incidence of invasive candidiasis in the whole hospital and the ICU but in lower proportions (+ 20.0% and + 10.9%, respectively). Conclusions We observed an increased consumption of antifungals including voriconazole and caspofungin in our hospital during the COVID-19 pandemic and explained in part by an increased incidence of invasive fungal diseases in COVID-19 patients. These results are of utmost importance as it raises concern about the urgent need for appropriate antifungal stewardship activities to control antifungal consumption

Additional file 5 of Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation

Additional file 5. Answers to Case 3

Additional file 3 of Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation

Additional file 3. Answers to Case 1

Additional file 8 of Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation

Additional file 8 Answers according to large et small volume centers. The groups were defined on the median of lung transplants performed in 2017 (n = 28). LTx: lung transplantation

Additional file 2 of Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation

Additional file 2. Raw anonymized answers of the 99 participant

Additional file 6 of Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation

Additional file 6. Answers to Case 4

Additional file 7 of Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation

Additional file 7. Answers to Case 5

Additional file 4 of Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation

Additional file 4. Answers to Case 2