Strategies to Improve the Anti-Cancer Properties of Gold(III) Complexes

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The cytotoxic effects of lipidic formulated gold porphyrin nanoparticles for the treatment of neuroblastoma

Objective: Nanotechnology has been identified as a promising platform in the improvement of the design and development of drug delivery systems. In the present study we investigated the potential of lipidic nanoparticles consisting of gold porphyrin for the treatment of neuroblastoma. Materials and methods: To characterize the size of the lipidic gold porphyrin nanoparticles, we used transmission electron microscopy (TEM). The in vitro cytotoxic effect on neuroblastoma activity was examined using XTT cell proliferation assay, then IC50 values were calculated. In vivo safety and toxicity were studied using intraperitoneal injection of gold porphyrin nanoparticles into normal animals. Finally, tumor size measurement and animal survival were studied to investigate the therapeutic effect of lipidic gold porphyrin nanoparticles on neuroblastoma growth. Results: We found that incorporation of gold porphyrin into lipidic nanoparticles resulted in a 16-fold increase in size. Subsequent in vitro and in vivo cytotoxicity studies further showed that the lipidic gold porphyrin nanoparticles could decrease systemic toxicity, as well as inhibiting tumor growth following administration into the neuroblastoma bearing mice. Conclusion: The delivery of lipidic gold porphyrin nanoparticles by incorporation with lipidic formulation is feasible approach to treat neuroblastoma. We await further studies to evaluate tumor killing kinetics. © 2010 Lee et al, publisher and licensee Dove Medical Press Ltd.published_or_final_versio

Fabrication of Worm-Like Nanorods and Ultrafine Nanospheres of Silver Via Solid-State Photochemical Decomposition

Worm-like nanorods and nanospheres of silver have been synthesized by photochemical decomposition of silver oxalate in water by UV irradiation in the presence of CTAB and PVP, respectively. No external seeds have been employed for the synthesis of Ag nanorods. The synthesized Ag colloids have been characterized by UV-visible spectra, powder XRD, HRTEM, and selected area electron diffraction (SAED). Ag nanospheres of average size around 2 nm have been obtained in the presence of PVP. XRD and TEM analyses revealed that top and basal planes of nanorods are bound with {111} facets. Williamson–Hall plot has revealed the presence of defects in the Ag nanospheres and nanorods. Formation of defective Ag nanocrystals is attributed to the heating effect of UV-visible irradiation

Therapeutic applications of gold complexes: lipophilic gold(III) cations and gold(I) complexes for anti-cancer treatment

Gold and its complexes have long been known to display unique biological and medicinal properties. Extensive cell-based (in vitro) and animal (in vivo) studies have revealed the potent anti-cancer activities of diverse classes of gold(I) and gold(III) complexes. Most of the reported anti-cancer active gold complexes are highly cytotoxic and unstable under physiological conditions, which hamper their development to be launched clinically. Several clinical reports showed that lipophilic organic cations are promising anti-cancer drug candidates targeting to mitochondria. Through metal-ligand coordination, gold(I) and gold(III) ions can form stable lipophilic cations containing organic ligands having tunable lipophilicity and diverse functionalities. The present highlight summarizes the recent development of lipophilic gold(III) cations and gold(I) complexes with promising anti-cancer activities.link_to_subscribed_fulltex

The anti-cancer properties of gold(III) compounds with dianionic porphyrin and tetradentate ligands

Gold(III) compounds have long been investigated for anti-cancer treatment. However, clinical use has often been hampered by their poor stability in solution. A reduction of gold(III) to gold(I) is usually the case for most cytotoxic gold(III) compounds. Previously, we made use of planar tetradentate dianionic ligands, including porphyrin, Schiff base and bis(pyridyl)carboxamide ligands, to prepare a series of monocationic gold(III) compounds. These gold(III) compounds behave as organic lipophilic cations with a planar structure, are stable under physiological conditions, and possess certain promising anti-cancer activities. In this review, the synthesis, stability, and anti-cancer properties of these gold(III) compounds are presented. We shall detail the in vitro and in vivo anti-cancer efficacy, as well as the anti-cancer mechanisms of the most potent gold(III) porphyrin compound [AuIII(TPP)]Cl (1a). © 2009 Elsevier B.V. All rights reserved.link_to_subscribed_fulltex

Typgeprüfte mittelspannungs-vakuum-lasttrennschalter bis 12 kV

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A dual cytotoxic and anti-angiogenic water-soluble gold(iii) complex induces endoplasmic reticulum damage in HeLa cells

The water-soluble gold(iii) complex [Au III(butyl-CN)biguanide]Cl (butyl-HCN = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations. © 2012 The Royal Society of Chemistry.link_to_subscribed_fulltex

In vitro inhibition of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase by gold(III) porphyrins

A cationic gold(III) porphyrin, [AuIII(TM-PyP)]Cl5 (1 a), is a potent HIV-1 reverse transcriptase inhibitor in vitro with an IC 50 value = 0.31 μM. Effective inhibition (67%) can be produced by the "1 a + AZT-TP" protocol at nanomolar level. The gold(III) complex exhibits remarkable stability in physiological buffer without significant cytotoxicity to normal T cells.link_to_subscribed_fulltex