Vitamin E in Hemodialysis Patients

End-stage renal disease patients treated with hemodialysis are characterized by a special diet, increased oxidative stress, cardiovascular morbidity and mortality, as well as many other complications such as inflammation-malnutrition syndrome, muscle cramps, and anemia. Worldwide efforts are focused on reducing hemodialysis complications to increase survival in these patients. In vitro and in vivo studies proved that vitamin E has many beneficial effects such as: decreases reactive oxygen species synthesis, improves antioxidant defense system, inhibits lipids peroxidation and reduces atherosclerosis, and ameliorates anemia treatment. Mechanisms of action are complex and not fully understood. However, there are particularities in regards of vitamin E intake, metabolism, and clearance in patients treated with hemodialysis. Supplementation of vitamin E in these patients has been intensively studied, and it is still under debate. Oral administration and vitamin E-coated membranes for dialysis have been tried. Clinical practice guidelines tried to underline when and how much vitamin E to be given to be safe and cost-beneficial. The current chapter aims to synthesize all these issues

TRANSFER OF HEAVY METALS IN SOIL IN-PLUM CULTIVATION: A FIELD STUDY IN ADAMACHI IASI, ROMANIA

Currently, global environmental concerns about heavy metal pollution are driven by rapid urbanization and industrial development. Therefore, a field study was conducted to assess the concentration of heavy metals (Pb, Co, Zn, Ni and Cu) in orchard soils and its transfer to two plum varieties (Stanley and Anna Späth) at Adamachi Farm – Iasi University of Life Sciences (IULS). In addition, heavy metal transfer (MTF), daily metals intake (DIM) and the index of health risk (HRI) were evaluated. The concentration of Pb, Co, Zn, Ni and Cu in soil and plum leaves samples were analyzed using atomic absorption spectrometry after acid digestion with a mixture of HNO3 (65%), HCl (37%) and HClO4 (60%). Metal concentration patterns occurred as follows 130.65>76.6>30.36> 21.69>13.26 mg/kg for Cu, Zn, Ni, Pb and Co in soil samples and 20.16>10.00> 2.10>1.68 mg/kg for Zn, Cu, Ni and Pb in plum leaves, while Co residue was not detected. The maximum heavy metal concentrations were found at the soil surface (0 – 30 cm depth) due to soil organo-mineral content and antifungal treatments. The health risk index predicted (HRI) for adults as well as children was in the sequence Pb > Cu > Ni > Zn, suggesting no health risk with values that did not exceed the safe limit (1). Therefore, it is essential to manage the causes and sources of heavy metal transfer prudently and effectively in order to prevent environmental contamination

Transfer of heavy metals in soil in-plum cultivation: a field study in Adamachi Iasi, Romania

Currently, global environmental concerns about heavy metal pollution are driven by rapid urbanization and industrial development. Therefore, a field study was conducted to assess the concentration of heavy metals (Pb, Co, Zn, Ni and Cu) in orchard soils and its transfer to two plum varieties (Stanley and Anna Späth) at Adamachi Farm – Iasi University of Life Sciences (IULS). In addition, heavy metal transfer (MTF), daily metals intake (DIM) and the index of health risk (HRI) were evaluated. The concentration of Pb, Co, Zn, Ni and Cu in soil and plum leaves samples were analyzed using atomic absorption spectrometry after acid digestion with a mixture of HNO3 (65%), HCl (37%) and HClO4 (60%). Metal concentration patterns occurred as follows 130.65>76.6>30.36> 21.69>13.26 mg/kg for Cu, Zn, Ni, Pb and Co in soil samples and 20.16>10.00> 2.10>1.68 mg/kg for Zn, Cu, Ni and Pb in plum leaves, while Co residue was not detected. The maximum heavy metal concentrations were found at the soil surface (0 – 30 cm depth) due to soil organo-mineral content and antifungal treatments. The health risk index predicted (HRI) for adults as well as children was in the sequence Pb > Cu > Ni > Zn, suggesting no health risk with values that did not exceed the safe limit (1). Therefore, it is essential to manage the causes and sources of heavy metal transfer prudently and effectively in order to prevent environmental contamination

Correlations between the adaptive capacity in Bucovina of Limousine cows and the nutritional quality of the milk

The Limousine breed is spread on all continents in 64 countries, and Romania will be the 65th country in which it is trying to adapt this breed of cattle. Limousine is currently ranked No. 1 in England and is highly regarded in other countries, including France, No. 2, Canada, No. 2, Italy, and the United States. 3rd place. The main objective of this project is to observe the adaptability of the Limousine breed to the geo-meteorological conditions recorded in northern Romania, the Bukovina region. The aim of the paper is to evaluate from a nutritional qualitative point of view the raw milk obtained from this breed. The investigations were carried out to establish the degree of freshness, integrity and we monitored some physical-chemical and hygienic parameters of the raw material milk. Sampling was done directly from the collection vessels after milking and filtration mainly in the hot season, and their processing was done in the Food Control Laboratory of the Faculty of Veterinary Medicine Iasi, where a number of 38 milk samples were processed. Following the analysis of the samples, a number of 8 samples were inadequate in terms of organoleptic examination and integrity. Deviations from the organoleptic characteristics of the parameters of appearance, color, smell, and taste represented a percentage of 21.05%. The determinations of the Physico-chemical parameters were classified as inappropriate a number of 10 samples which represents a percentage of 26.31% of the total samples collected

Effect of silver nanoparticle and organic biostimulator nitrozime over micropores and germination, growth and development of seeds of Triticum aestivum to level of a bio accumulative horizon type cambic soil

The present paper monitors the effect of applying different doses of silver nanoparticles (10 ppm, 15 ppm, 20 ppm), and the effect of organic biostimulator Nitrozimes (2ml/l) on the germination, growing and development of the Triticum aestivum species. The changes suffered by the bioaccumulation horizon of the cambic chernozem at micro porous level is also investigated. The silver nanoparticle solution is obtained through electrolysis technique in miliQ water solvent using Nevoton IS-112 device with silver electrodes of 99.99% purity. The determination of the ppm quantity is realized by using TDS-1. The seed germination is tracked in a controlled environment (Petri dishes) in laboratory conditions for 10 days until germination. After, they are transferred in vegetation dishes in the grow house and tracked in a controlled environment of temperature, humidity and soil pH. Data on the micro porosity was taken and analyzed at I.C.A.M. Laboratories in the V. Adamachi resort using micro computed tomography (Brucker Skyscan 1172). The germination evolution, growth and development of the wheat plants was measured weekly throughout the growing season. The results show a reduction in the diameter of the micropores that is inversely proportional to the concentration of silver ions doses applied. From the germination phase until 2-3 leafs stage, the growth is approximately double than the development of the witness plants (untreated wheat grown in bioaccumulative horizon). Key words: silver nanoparticles, biostimulator, soil structure

Research and Science Today No.2

Research and Science Today Journal is a publication founded in 2011 and it is dedicated to the students of all levels (license, master and doctoral) of faculties in the country and abroad. We want to offer the participants the opportunity to present their scientific works in the following areas: Social Sciences, Economic Sciences, Legal Sciences, Humanities, Education Sciences, Engineering, Medicine and Sport. This journal provides students the opportunity to create and / or to improve their abilities to write scientific papers. So each appearance (two appearances per year at which we can add supplements) contains a number of papers written by students, masters and doctoral from the faculties from the country or / and abroad. The journal promotes original studies contributing to the progress of knowledge and it is motivated by the need to address issues of theory and practice in the areas mentioned above. The Journal is a training means of the factors involved in the conceptualization, development, implementation and evaluation , aiming the formation of creative personalities who could be able to adapt through the changing conditions of life. Journal wants to be a forum for debates disciplinaries and interdisciplinaries theoretical topics, to become a research support, to leverage this work at regional, national and international levels. We believe that this gathering will enjoy the support from both parts of the researchers and of the practitioners, and will provide appropriate training sources held professional through the current problems

Research and Science Today No.2

Research and Science Today Journal is a publication founded in 2011 and it is dedicated to the students of all levels (license, master and doctoral) of faculties in the country and abroad. We want to offer the participants the opportunity to present their scientific works in the following areas: Social Sciences, Economic Sciences, Legal Sciences, Humanities, Education Sciences, Engineering, Medicine and Sport. This journal provides students the opportunity to create and / or to improve their abilities to write scientific papers. So each appearance (two appearances per year at which we can add supplements) contains a number of papers written by students, masters and doctoral from the faculties from the country or / and abroad. The journal promotes original studies contributing to the progress of knowledge and it is motivated by the need to address issues of theory and practice in the areas mentioned above. The Journal is a training means of the factors involved in the conceptualization, development, implementation and evaluation , aiming the formation of creative personalities who could be able to adapt through the changing conditions of life. Journal wants to be a forum for debates disciplinaries and interdisciplinaries theoretical topics, to become a research support, to leverage this work at regional, national and international levels. We believe that this gathering will enjoy the support from both parts of the researchers and of the practitioners, and will provide appropriate training sources held professional through the current problems

Increased glycemic variability in type 2 diabetes patients treated with insulin - a real-life clinical practice, continuous glucose monitoring (CGM) study

Chronic hyperglycemia is an important cause for the development of chronic complications of diabetes, but glycemic variability has emerged in recent years as an independent contributor to diabetes-related complications. Our objective was to evaluate glycemic variability in patients with T2DM treated with insulin compared with other antidiabetic drugs. In this retrospective study, we collected 24-hour continuous glucose monitoring (CGM) recording data from 95 patients with T2DM, of which 27 treated with insulin and 68 with non-insulin treatment. We calculated and compared 16 glucose variability parameters in the insulin-treated and non-insulin treated groups. Insulin treated patients had significantly higher values of parameters describing the amplitude of glucose value fluctuations (standard deviation of glucose values, percentage coefficient of variation [%CV], and mean amplitude of glycemic excursion [MAGE], p <0.05) and time-dependent glucose variability (percentage of time with glycemic values below 70 mg/dl and continuous overall net glycemic action [CONGA] at 2, 4 and 6 hours, p <0.05). In conclusion, insulin therapy in T2DM is correlated with significantly higher glycemic variability

The correlation of dawn phenomenon with glycemic variability parameters in type 2 diabetes mellitus

Introduction. Dawn phenomenon could have deleterious effect on overall glycemic control. Glycemic variability may be an independent risk factor for the development of diabetes chronic complications. The study aimed to evaluate any correlations between the dawn phenomenon and parameters of glycemic variability in a cohort of type 2 diabetes patients (T2DM). Material and methods. This retrospective observational study included 131 T2DM patients. Continuous glucose monitoring (CGM) has been performed. Data from the first 24h of full recording were used for analysis of glycemic variability indices: mean level of 24h interstitial glucose value and standard deviation; % coefficient of variation; J index; mean amplitude of glycemic excursion - MAGE; continuous overall net glycemic action (CONGA) at 1, 2, 4 and 6 hours; mean of daily differences (MODD) index. Results. Mean age was 56.04 ± 9.91 years, 35.9% women, 17.6% on diet, 53.4% on oral therapy and 29% on insulin. Dawn phenomenon was more frequent in patients below 60 years (70%) and in oral therapy group (72.85%). Significant correlations between the dawn phenomenon and j-index, MAGE, CONGA-4 and CONGA-6 have been found in T2DM patients on diet therapy alone. The amplitude of dawn phenomenon was 46.10 ± 24.40 mg/dl and significantly correlated (p<0.05) after adjustment for age, gender and treatment with % CV, MAGE, CONGA-1, CONGA-2, CONGA-4, CONGA-6 and MODD. Conclusions. The dawn phenomenon significantly increases the glycemic variability parameters in drug-naive T2DM patients, with no impact in T2DM on oral or insulin therapy

Validation of the Romanian Version of a Self-Administered Food Frequency Questionnaire

Background and aims: The present study aimed to assess the relative validity of the Romanian version of a food frequency questionnaire (FFQ) in evaluating habitual dietary intake