The effects of equine-assisted activities on the social functioning in children and adolescents with autism spectrum disorder

Equine-assisted activities and therapies are increasing in popularity for treatment of ASD symptoms. This research evaluated effects of a 5-week programme of therapeutic riding on social functioning of children/adolescents (N = 15) with ASD. The effectiveness of the programme was evaluated using the autism spectrum quotient, the Vineland Adaptive Behaviour Scale and the empathising and systemising quotient. Results established that the TR intervention increased empathising and reduced maladaptive behaviours. The findings also indicated that specific adaptive behaviours like socialization and communication were not affected by the intervention. Thus, a complex picture of the effects of this intervention emerges: while TR does not change all of the child’s behaviour, it can improve specific aspects of social functioning and also reduce maladaptive ASD traits

The embedded tumor: host physiology is important for the interpretation of tumor growth.

The growth potential of a tumour can significantly depend on host features such as age, cell proliferation rates and caloric intake. Although this is widely known, existing mathematical models for tumour growth do not account for it. We therefore developed a new model for tumour growth, starting from a mathematical framework that describes the host's physiology. The resulting tumour-in-host model allowed us to study the implications of various specific interactions between the energetics of tumour and host. The model accounts for the influence of both age and feeding regimen of the host organism on the behaviour of a tumour. Concerning the effects of a tumour on its host, it explains why tumour-mediated body-weight loss is often more dramatic than expected from the energy demands of the tumour. We also show how the model can be applied to study enhanced body-weight loss in presence of cachectic factors. Our tumour-in-host model thus appears a proper tool to unite a wide range of phenomena in tumour-host interactions. © 2003 Cancer Research UK