180 research outputs found
Interpreting Helioseismic Structure Inversion Results of Solar Active Regions
Helioseismic techniques such as ring-diagram analysis have often been used to
determine the subsurface structural differences between solar active and quiet
regions. Results obtained by inverting the frequency differences between the
regions are usually interpreted as the sound-speed differences between them.
These in turn are used as a measure of temperature and magnetic-field strength
differences between the two regions. In this paper we first show that the
"sound-speed" difference obtained from inversions is actually a combination of
sound-speed difference and a magnetic component. Hence, the inversion result is
not directly related to the thermal structure. Next, using solar models that
include magnetic fields, we develop a formulation to use the inversion results
to infer the differences in the magnetic and thermal structures between active
and quiet regions. We then apply our technique to existing structure inversion
results for different pairs of active and quiet regions. We find that the
effect of magnetic fields is strongest in a shallow region above 0.985R_sun and
that the strengths of magnetic-field effects at the surface and in the deeper
(r < 0.98R_sun) layers are inversely related, i.e., the stronger the surface
magnetic field the smaller the magnetic effects in the deeper layers, and vice
versa. We also find that the magnetic effects in the deeper layers are the
strongest in the quiet regions, consistent with the fact that these are
basically regions with weakest magnetic fields at the surface. Because the
quiet regions were selected to precede or follow their companion active
regions, the results could have implications about the evolution of magnetic
fields under active regions.Comment: Accepted for publication in Solar Physic
YREC: The Yale Rotating Stellar Evolution Code
The stellar evolution code YREC is outlined with emphasis on its applications
to helio- and asteroseismology. The procedure for calculating calibrated solar
and stellar models is described. Other features of the code such as a non-local
treatment of convective core overshoot, and the implementation of a
parametrized description of turbulence in stellar models, are considered in
some detail. The code has been extensively used for other astrophysical
applications, some of which are briefly mentioned at the end of the paper.Comment: 10 pages, 2 figures, ApSS accepte
Presupernova Structure of Massive Stars
Issues concerning the structure and evolution of core collapse progenitor
stars are discussed with an emphasis on interior evolution. We describe a
program designed to investigate the transport and mixing processes associated
with stellar turbulence, arguably the greatest source of uncertainty in
progenitor structure, besides mass loss, at the time of core collapse. An
effort to use precision observations of stellar parameters to constrain
theoretical modeling is also described.Comment: Proceedings for invited talk at High Energy Density Laboratory
Astrophysics conference, Caltech, March 2010. Special issue of Astrophysics
and Space Science, submitted for peer review: 7 pages, 3 figure
Recent Advances in Modeling Stellar Interiors
Advances in stellar interior modeling are being driven by new data from
large-scale surveys and high-precision photometric and spectroscopic
observations. Here we focus on single stars in normal evolutionary phases; we
will not discuss the many advances in modeling star formation, interacting
binaries, supernovae, or neutron stars. We review briefly: 1) updates to input
physics of stellar models; 2) progress in two and three-dimensional evolution
and hydrodynamic models; 3) insights from oscillation data used to infer
stellar interior structure and validate model predictions (asteroseismology).
We close by highlighting a few outstanding problems, e.g., the driving
mechanisms for hybrid gamma Dor/delta Sct star pulsations, the cause of giant
eruptions seen in luminous blue variables such as eta Car and P Cyg, and the
solar abundance problem.Comment: Proceedings for invited talk at conference High Energy Density
Laboratory Astrophysics 2010, Caltech, March 2010, submitted for special
issue of Astrophysics and Space Science; 7 pages; 5 figure
Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy
Developmental epileptic encephalopathies are devastating disorders characterized by intractable epileptic seizures and developmental delay. Here, we report an allelic series of germline recessive mutations in UGDH in 36 cases from 25 families presenting with epileptic encephalopathy with developmental delay and hypotonia. UGDH encodes an oxidoreductase that converts UDP-glucose to UDP-glucuronic acid, a key component of specific proteoglycans and glycolipids. Consistent with being loss-of-function alleles, we show using patients’ primary fibroblasts and biochemical assays, that these mutations either impair UGDH stability, oligomerization, or enzymatic activity. In vitro, patient-derived cerebral organoids are smaller with a reduced number of proliferating neuronal progenitors while mutant ugdh zebrafish do not phenocopy the human disease. Our study defines UGDH as a key player for the production of extracellular matrix components that are essential for human brain development. Based on the incidence of variants observed, UGDH mutations are likely to be a frequent cause of recessive epileptic encephalopathy
Volume I. Introduction to DUNE
The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE\u27s physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology
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