Nonhalogenated organic molecules from Laurencia algae

The marine red algae of the genus Laurencia have produced more 700 secondary metabolites and exhibited high molecular diversity and intriguing bioactivity. Since the halogenated structures have been comprehensively reviewed previously, this review, covering up to the end of 2012, mainly focuses on the source, structure elucidation, and bioactivity of nonhalogenated organic molecules from Laurencia spp. as well as the relationship between nonhalogenated and halogenated products. Overall, 173 new or new naturally occurring compounds with 58 skeletons, mainly including sesquiterpenes, diterpenes, triterpenes, and C15-acetogenins, are described.The marine red algae of the genus Laurencia have produced more 700 secondary metabolites and exhibited high molecular diversity and intriguing bioactivity. Since the halogenated structures have been comprehensively reviewed previously, this review, covering up to the end of 2012, mainly focuses on the source, structure elucidation, and bioactivity of nonhalogenated organic molecules from Laurencia spp. as well as the relationship between nonhalogenated and halogenated products. Overall, 173 new or new naturally occurring compounds with 58 skeletons, mainly including sesquiterpenes, diterpenes, triterpenes, and C-15-acetogenins, are described

Effect of coculture with oviduct epithelial cells on viability after transfer of vitrified in vitro produced goat embryos

International audienc

Galactic conformity at few Mpc scales

The environment within dark matter haloes can quench the star formation of galaxies. However, environmental effects beyond the virial radius of haloes ($\gtrsim$ 1 Mpc) are less evident. An example is the debated correlation between colour or star formation in central galaxies and neighbour galaxies in adjacent haloes at large separations of several Mpc, referred to as two-halo galactic conformity. We use two galaxy catalogues generated from different versions of the semi-analytic model SAG applied to the MDPL2 cosmological simulation and the IllustrisTNG300 cosmological hydrodynamical simulation to study the two-halo conformity by measuring the quenched fraction of neighbouring galaxies as a function of the real-space distance from central galaxies. We find that low-mass central galaxies in the vicinity of massive systems ($M_{\rm 200c}$ $\geq$ 10$^{13}$ $h^{-1}~\rm M_{\odot}$) out to 5 $h^{-1}$ Mpc are preferentially quenched compared to other central galaxies at fixed stellar mass $M_{\star}$ or fixed host halo mass $M_{\rm 200c}$ at $z$ ~ 0. In all the galaxies catalogues is consistent that the low-mass ($M_{\star} < 10^{10}$ $h^{-1}~\rm M_{\odot}$ or $M_{\rm 200c} < 10^{11.8}$ $h^{-1}~\rm M_{\odot}$) central galaxies in the vicinity of groups and clusters of galaxies mostly produce the two-halo galactic conformity. On average, the quenched low-mass central galaxies are typically much closer to massive haloes than star-forming central galaxies of the same mass (by a factor of ~5). Our results support that the environmental influence of massive haloes can extend beyond the virial radius and affect nearby low-mass central galaxies.Comment: 17 pages, 12 Figures. Submitted to MNRA

Powering the planet: Chemical challenges in solar energy utilization

Global energy consumption is projected to increase, even in the face of substantial declines in energy intensity, at least 2-fold by midcentury relative to the present because of population and economic growth. This demand could be met, in principle, from fossil energy resources, particularly coal. However, the cumulative nature of CO(2) emissions in the atmosphere demands that holding atmospheric CO(2) levels to even twice their preanthropogenic values by midcentury will require invention, development, and deployment of schemes for carbon-neutral energy production on a scale commensurate with, or larger than, the entire present-day energy supply from all sources combined. Among renewable energy resources, solar energy is by far the largest exploitable resource, providing more energy in 1 hour to the earth than all of the energy consumed by humans in an entire year. In view of the intermittency of insolation, if solar energy is to be a major primary energy source, it must be stored and dispatched on demand to the end user. An especially attractive approach is to store solar-converted energy in the form of chemical bonds, i.e., in a photosynthetic process at a year-round average efficiency significantly higher than current plants or algae, to reduce land-area requirements. Scientific challenges involved with this process include schemes to capture and convert solar energy and then store the energy in the form of chemical bonds, producing oxygen from water and a reduced fuel such as hydrogen, methane, methanol, or other hydrocarbon species

Signal transduction induced in Trypanosoma cruzi metacyclic trypomastigotes during the invasion of mammalian cells

Penetration of Trypanosoma cruzi into mammalian cells depends on the activation of the parasite's protein tyrosine kinase and on the increase in cytosolic Ca2+ concentration. We used metacyclic trypomastigotes, the T. cruzi developmental forms that initiate infection in mammalian hosts, to investigate the association of these two events and to identify the various components of the parasite signal transduction pathway involved in host cell invasion. We have found that i) both the protein tyrosine kinase activation, as measured by phosphorylation of a 175-kDa protein (p175), and Ca2+ mobilization were induced in the metacyclic forms by the HeLa cell extract but not by the extract of T. cruzi-resistant K562 cells; ii) treatment of parasites with the tyrosine kinase inhibitor genistein blocked both p175 phosphorylation and the increase in cytosolic Ca2+ concentration; iii) the recombinant protein J18, which contains the full-length sequence of gp82, a metacyclic stage surface glycoprotein involved in target cell invasion, interfered with tyrosine kinase and Ca2+ responses, whereas the monoclonal antibody 3F6 directed at gp82 induced parasite p175 phosphorylation and Ca2+ mobilization; iv) treatment of metacyclic forms with phospholipase C inhibitor U73122 blocked Ca2+ signaling and impaired the ability of the parasites to enter HeLa cells, and v) drugs such as heparin, a competitive IP3-receptor blocker, caffeine, which affects Ca2+ release from IP3-sensitive stores, in addition to thapsigargin, which depletes intracellular Ca2+ compartments and lithium ion, reduced the parasite infectivity. Taken together, these data suggest that protein tyrosine kinase, phospholipase C and IP3 are involved in the signaling cascade that is initiated on the parasite cell surface by gp82 and leads to Ca2+ mobilization required for target cell invasion