Endovascular Management Of Extremity Arterial Trauma

Treatment of arterial traumatic injuries is usually performed with conventional revascularization techniques. However, vascular injuries can increasingly be repaired efficiently through minimally invasive procedures. We report four cases of extremity arterial trauma treated by endovascular techniques in a reference center. All patients showed satisfactory development over a 15-month follow-up. We suggest that endovascular therapy is a promising alternative to surgery for selected patients with extremity arterial trauma.715661Deguara, J., Ali, T., Modarai, B., Burnand, K.G., Upper limb ischemia: 20 years experience from a single center (2005) Vascular, 13, pp. 84-91Huynh, T.T., Pham, M., Griffin, L.W., Management of distal femoral and popliteal arterial injuries: An update (2006) Am J Surg, 192, pp. 773-778Peck, M.A., Rasmussen, T.E., Management of blunt peripheral arterial injury (2006) Perspect Vasc Surg Endovasc Ther, 18, pp. 159-173Vasdekis, S.N., Kakisis, J.D., Lazaris, A.M., Panayiotides, J.G., Angeli, A.A., Karkaletsis, K.G., Common femoral artery injury secondary to tennis ball strike (2006) J Vasc Surg, 44, pp. 1350-1352Starnes, B.W., Arthurs, Z.M., Endovascular management of vascular trauma (2006) Perspect Vasc Surg Endovasc Ther, 18, pp. 114-129Criado, E., Marston, W.A., Ligush, J., Mauro, M.A., Keagy, B.A., Endovascular repair of peripheral aneurysms, pseudoaneurysms and arteriovenous fistulas (1997) Ann Vasc Surg, 11, pp. 253-263du Toit, D.F., Strauss, D.C., Blaszczyk, M., de Villiers, R., Warren, B.L., Endovascular treatment of penetrating thoracic outlet arterial injuries (2000) Eur J Vasc Endovasc Surg, 19, pp. 489-495du Toit, D.F., Leith, J.G., Strauss, D.C., Blaszczyk, M., Odendaal, J.V., Warren, B.L., Endovascular management of traumatic cervicothoracic arteriovenous fistula (2003) Br J Surg, 90, pp. 1516-1521Kember, P.G., Wood, R.F., Gaines, P.A., Endovascular management of a non-penetrating traumatic axillary artery occlusion (1997) Eur J Vasc Endovasc Surg, 14, pp. 227-228Mattox KL, Hirshberg A. Traumatismo vascular. In: Haimovici H, editor. Cirurgia vascular. Rio de Janeiro: Di-Livros2000. p. 480-96Strauss, D.C., du Toit, D.F., Warren, B.L., Endovascular repair of occluded subclavian arteries following penetrating trauma (2001) J Endovasc Ther, 8, pp. 529-533Kuzniec, S., Traumatismos vasculares (2002) Cirurgia vascular, pp. 706-720. , Brito CJ, editor, Rio de Janeiro: Revinter;Aun, R., Leão, P.P., Tratamento dos ferimentos vasculares por métodos endovasculares (2002) Cirurgia vascular, pp. 721-727. , Brito CJ, editor, Rio de Janeiro: Revinter;Lönn, L., Delle, M., Karlström, L., Risberg, B., Should blunt arterial trauma to the extremities be treated with endovascular techniques? (2005) J Trauma, 59, pp. 1224-1227Alvarez-Tostado, J., Tulsyan, N., Butler, B., Rizzo, A., Endovascular management of acute critical ischemia secondary to blunt tibial artery injury (2006) J Vasc Surg, 44, pp. 1101-1103Johnson SF, Johnson SB, Strodel WE, Barker DE, Kearney PA. Brachial plexus injury: association with subclavian and axillary vascular trauma. J Trauma. 1991;31:1546-50. J Vasc Bras. 2008;7(1):62-

The Chemical Evolution of the Milky Way

The field of chemical evolution modeling of the Galaxy is experiencing in the last years a phase of high activity and important achievements. There are, however, several open questions which still need to be answered. In this review I summarize what have been the most important achievements and what are some of the most urgent questions to be answered.Comment: 10 pages including 3 figs, to appear in "The Chemical Evolution of the Milky Way. Stars vs Clusters", Proceedings of the Sept.1999 Vulcano Workshop, F.Giovannelli and F.Matteucci eds (Kluwer, Dordrecht) in pres

Protective effect of Melissa officinalis aqueous extract against Mn-induced oxidative stress in chronically exposed mice

AbstractManganese (Mn) is an essential element for biological systems; however occupational exposure to high levels of this metal may lead to neurodegenerative disorders, resembling Parkinson's disease (PD). While its mechanisms of neurotoxicity have yet to be fully understood, oxidative stress plays a critical role. Thus, the main goal of this study was to investigate the efficacy of aqueous extract of Melissa officinalis in attenuating Mn-induced brain oxidative stress in mice. Sixteen male mice were randomly divided into two groups and treated for 3 months: the first group consumed tap water (control group) and the second group was treated with Mn (50mg/kg/day for habituation during the first 15 days followed by 100mg/kg/day for additional 75 days) in the drinking water. After 3 months both groups were sub divided (n=4 per group) and treated for additional 3 months with Mn and/or M. officinalis in the drinking water. The first group (control) was treated with water and served as control; the second group (M. officinalis) was treated with M. officinalis (100mg/kg/day); the third group was treated with Mn (100mg/kg/day); the fourth group (Mn+M. officinalis) was treated with both Mn and M. officinalis (100mg/kg/day each). Mn-treated mice showed a significant increase in thiobarbituric acid reactive species (TBARS) levels (a marker of oxidative stress) in both the hippocampus and striatum. These changes were accompanied by a decrease in total thiol content in the hippocampus and a significant increase in antioxidant enzyme activity (superoxide dismutase and catalase) in the hippocampus, striatum, cortex and cerebellum. Co-treatment with M. officinalis aqueous extract in Mn-treated mice significantly inhibited the antioxidant enzyme activities and attenuated the oxidative damage (TBARS and decreased total thiol levels). These results establish that M. officinalis aqueous extract possesses potent antioxidative properties, validating its efficacy in attenuating Mn-induced oxidative stress in the mouse brain

Some aspects of the venom proteome of the Colubridae snake Philodryas olfersii revealed from a Duvernoy’s (venom) gland transcriptome

AbstractWe investigated the putative toxins of Philodryas olfersii (Colubridae), a representative of a family of snakes neglected in venom studies despite their growing medical importance. Transcriptomic data of the venom gland complemented by proteomic analysis of the gland secretion revealed the presence of major toxin classes from the Viperidae family, including serine proteases, metalloproteases, C-type lectins, Crisps, and a C-type natriuretic peptide (CNP). Interestingly, the phylogenetic analysis of the CNP precursor showed it as a linker between two related precursors found in Viperidae and Elapidae snakes. We suggest that these precursors constitute a monophyletic group derived from the vertebrate CNPs

Quality control in blood irradiation

Irradiation is a technique used in hemotherapy to functionally inactivateviable lymphocytes, in cellular blood components, to reduce the risk of Transfusion-associated Graft-versus-Host Disease (AT-GVHD), is rare but letal. One way to avoid it is to irradiate blood componentes in situations such as: intrauterine transfusion, newborns, patients receiving immunosuppressive therapy in bone marrow transplantation. Thus, it is extremely important that blood component is irradiated and, above all, ensure that the minimum dose is 25 Gy.The blood policy in Brazil is implemented through laws and normative decrees, giving rise to a legal system that underpins the actions of hemotherapy services. In order to correct verify absorbed doses and the quality assurance process as well as the safety for the irradiator operators we describe in this paper a several of physical measurements that is mandatory to support a physicist to evaluate the quality assurance during and after the irradiation process. The results obtained from this physical measurements  provided a guarantee of proper radiation dose used in hemotherapy as well as methods and procedures applied to protect the patient, employees and general public due to procedure of blood irradiation accordling the Technical Regulation of Hemotherapy Procedures of the National Health Surveillance Agency (ANVISA) and safety regulations by National Nuclear Energy Commission (CNEN)