Semiclassical Trace Formulas for Noninteracting Identical Particles

We extend the Gutzwiller trace formula to systems of noninteracting identical particles. The standard relation for isolated orbits does not apply since the energy of each particle is separately conserved causing the periodic orbits to occur in continuous families. The identical nature of the particles also introduces discrete permutational symmetries. We exploit the formalism of Creagh and Littlejohn [Phys. Rev. A 44, 836 (1991)], who have studied semiclassical dynamics in the presence of continuous symmetries, to derive many-body trace formulas for the full and symmetry-reduced densities of states. Numerical studies of the three-particle cardioid billiard are used to explicitly illustrate and test the results of the theory.Comment: 29 pages, 11 figures, submitted to PR

Universal DNA methylation age across mammalian tissues

DATA AVAILABILITY STATEMENT : The individual-level data from the Mammalian Methylation Consortium can be accessed from several online locations. All data from the Mammalian Methylation Consortium are posted on Gene Expression Omnibus (complete dataset, GSE223748). Subsets of the datasets can also be downloaded from accession numbers GSE174758, GSE184211, GSE184213, GSE184215, GSE184216, GSE184218, GSE184220, GSE184221, GSE184224, GSE190660, GSE190661, GSE190662, GSE190663, GSE190664, GSE174544, GSE190665, GSE174767, GSE184222, GSE184223, GSE174777, GSE174778, GSE173330, GSE164127, GSE147002, GSE147003, GSE147004, GSE223943 and GSE223944. Additional details can be found in Supplementary Note 2. The mammalian data can also be downloaded from the Clock Foundation webpage: https://clockfoundation.org/MammalianMethylationConsortium. The mammalian methylation array is available through the non-profit Epigenetic Clock Development Foundation (https://clockfoundation.org/). The manifest file of the mammalian array and genome annotations of CpG sites can be found on Zenodo (10.5281/zenodo.7574747). All other data supporting the findings of this study are available from the corresponding author upon reasonable request. The chip manifest files, genome annotations of CpG sites and the software code for universal pan-mammalian clocks can be found on GitHub95 at https://github.com/shorvath/MammalianMethylationConsortium/tree/v2.0.0. The individual R code for the universal pan-mammalian clocks, EWAS analysis and functional enrichment studies can be also found in the Supplementary Code.SUPPLEMENTARY MATERIAL 1 : Supplementary Tables 1–3 and Notes 1–6.SUPPLEMENTARY MATERIAL 2 : Reporting SummarySUPPLEMENTARY MATERIAL 3 : Supplementary Data 1–14.SUPPLEMENTARY MATERIAL 4 : Supplementary Code.Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.https://www.nature.com/nataginghj2024Zoology and EntomologySDG-15:Life on lan

Nomenclatural Changes in the Neotropical Eumaeini (Lepidoptera, Lycaenidae, Theclinae)

Nomenclatural actions are taken in the Neotropical Eumaeini in advance of publication of the Atlas of Neotropical Lepidoptera Checklist. Lectotypes are designated for eleven species group names: Lycaena astiocha Prittwitz, 1865; Thecla azia Hewitson, 1873; Thecla beroea Hewitson, 1868; Thecla cupa Druce, 1907; Thecla daraba Hewitson, 1867; Thecla duma Hewitson, 1878; Thecla erenea Hewitson, 1867; Thecla galliena Hewitson, 1867; Thecla guacanagari Wallengren, 1860; Thecla stagira Hewitson, 1867; and Thecla thoria Hewitson, 1867. Thecla duma Hewitson, 1878 and Thecla columbinia Strand, 1916 are transferred from Eumaeini to Deudorigini (Theclinae). Lycaena vanessoides Prittwitz, 1865 is transferred from Polyommatinae to Theclinae (Eumaeini). Six type localities are changed: Colombia to Africa for Thecla columbinia Strand, 1916; Amazon to Guayaquil for Thecla daraba Hewitson, 1867; Colombia to Southeast Asia for Thecla duma Hewitson, 1878; Bolivia to Westem North America for Ignata illepida K. Johnson, 1992; Argentina to the United States for Strymon nivnix K. Johnson, Eisele & MacPherson, 1990; and Dominican Republic to mainland Central and South America for Tmolus victoria K. Johnson & Matusik, 1989. Seven new synonyms are: Lycaena vanessoides Prittwitz, 1865 = Thecla hygela Hewitson, 1868 syn. nov.; Thecla saepium Boisduval, 1852 = Ignata illepida K. Johnson, 1992 syn. nov.; Thecla tyriam H.H. Druce, 1907 = Zigirina minutia K. Johnson & Adams, 1997 syn. nov.; Thecla halciones Butler & H. Druce, 1872 = Decussata colombiana K. Johnson, Austin, Le Crom & Sal azar, 1997 syn. nov.; Papilio celmus Cramer, 1775 = Tmolus victoria K. Johnson & Matusik, 1989 syn. nov.; Thecla daraba Hewitson, 1867 = Thecla tyleri Dyar, 1913 syn. nov.; and Thecla galliena Hewitson, 1877 = Thecla iopas Godman & Salvin, 1887 syn. nov. The generic name Decussata K. Johnson, Austin, Le Crom & Salazar, 1997 is a new junior synonym of Ostrinotes K. Johnson, Austin, Le Crom & Salazar, 1997. The unavailable infra-subspecific name Thecla orobiana forma ♀ cosmophila Tessmann, 1928 is available as Thecla cosmophila Bridges, 1988. Seven new combinations are: Hypokopelates columbinia (Strand, 1916) comb. nov.; Mithras cosmophila Bridges, 1988 comb. nov.; Nicolaea cupa (Druce, 1907) comb. nov.; Salazaria elizabetha (Salazar, Vélez & K. Johnson, 1997) comb. nov.; Ostrinotes halciones (Butler & H. Druce, 1872) comb. nov.; Strephonota tyriam (H.H. Druce, 1907) comb. nov.; and Aubergina vanessoides (Prittwitz, 1865) comb. nov. The holotypes of seven eumaeines are composed of parts belonging to different species: Strymon andrewi K. Johnson & Matusik, 1988; Decussata colombiana K. Johnson, Austin, Le Crom & Salazar, 1997; Trochusinus elizabetha Salazar, Vélez & K. Johnson, 1997; lgnata illepida K. Johnson, 1992; Zigirina minutia K. Johnson & Adams, 1997; Strymon nivnix K. Johnson, Eisele & MacPherson, 1990; and Tmolus victoria K. Johnson & Matusik, 1989. Some parts of these holotypes are excluded to clarify the identity of these names. Three chronic misspellings are corrected: Papilio ganimedes Crarner, 1775, for Papilio ganymedes [sic] Fabricius, 1776;Thecla atnius Herrich-Schäffer, [1853], for Thecla atrius [sic] Herrich-Schäffer, [1858]; and Rusticus minyas Hübner, [1809], for Rusticus minijas [sic] Poey, 1832. The name Electrostrymon minikyanos K. Johnson & Matusik, 1988, is treated as a nomen dubium. The subjective synonymy of Thecla guacanagari Wallengren, 1860, and Thecla azia Hewitson, 1873, is referred to the International Commission on Zoological Nomenclature for conditional suppression of the first name. Precedence for the names Papilio dion Schaller, 1788, and Hesperia columella Fabricius, 1793, is reversed under Article 23.9.1 of the International Code of Zoological Nomenclature