6 research outputs found
Multi-Modal Proteomic Analysis of Retinal Protein Expression Alterations in a Rat Model of Diabetic Retinopathy
- Author
- AC MacKinnon
- AF Amos
- AJ Barber
- AM Joussen
- AM Joussen
- AW Stitt
- AW Stitt
- B Brachvogel
- BB Gao
- BB Gao
- BB Gao
- C Gerhardinger
- CF Taylor
- CW Denko
- D Sinha
- DA Vignali
- DB Allison
- E Costa
- E Fernandez
- EF Barber
- G Pugliese
- Georgina V. Bixler
- GG Quin
- H Vlassara
- HD VanGuilder
- HD VanGuilder
- Heather D. VanGuilder
- HO Hansen
- HW Kim
- J Bormann
- J Cunningham
- J Knudsen
- J Knudsen
- JH Shin
- K Frost-Larsen
- K Masuzawa
- K Tajima
- Karl-Wilhelm Koch
- L Choe
- L Hyvarinen
- LM Aiello
- LP Yang
- Lydia Kutzler
- M Bartoli
- M Daimon
- M Garcia-Ramirez
- M Garcia-Ramirez
- M Unlu
- M Zaunreiter
- MA Di Leo
- MD Davis
- N Cheung
- NC Henderson
- NH Barmack
- NH White
- NL Anderson
- P Canning
- PA Campochiaro
- PA Kumar
- PE Fort
- PS Chan
- R Klein
- R Lazzarini
- R Simo
- RA Kowluru
- RF Spaide
- RM Brucklacher
- RN Frank
- Robert M. Brucklacher
- S Liu
- S Oikari
- S Sokol
- Sarah K. Bronson
- Scot R. Kimball
- SJ Kirwin
- T Barrett
- T Gotow
- T Kim
- TJ Chu
- TM Umstead
- UP Andley
- UP Andley
- V Compere
- VK Deshmukh
- WH Tang
- Willard M. Freeman
- WL Lowe Jr
- WM Freeman
- WM Freeman
- WM Freeman
- WW Wu
- X Ying
- Y Munemasa
- Z Qian
- Publication venue
- Public Library of Science
- Publication date
- 13/01/2011
- Field of study
As a leading cause of adult blindness, diabetic retinopathy is a prevalent and profound complication of diabetes. We have previously reported duration-dependent changes in retinal vascular permeability, apoptosis, and mRNA expression with diabetes in a rat model system. The aim of this study was to identify retinal proteomic alterations associated with functional dysregulation of the diabetic retina to better understand diabetic retinopathy pathogenesis and that could be used as surrogate endpoints in preclinical drug testing studies.A multi-modal proteomic approach of antibody (Luminex)-, electrophoresis (DIGE)-, and LC-MS (iTRAQ)-based quantitation methods was used to maximize coverage of the retinal proteome. Transcriptomic profiling through microarray analysis was included to identify additional targets and assess potential regulation of protein expression changes at the mRNA level. The proteomic approaches proved complementary, with limited overlap in proteomic coverage. Alterations in pro-inflammatory, signaling and crystallin family proteins were confirmed by orthogonal methods in multiple independent animal cohorts. In an independent experiment, insulin replacement therapy normalized the expression of some proteins (Dbi, Anxa5) while other proteins (Cp, Cryba3, Lgals3, Stat3) were only partially normalized and Fgf2 and Crybb2 expression remained elevated.These results expand the understanding of the changes in retinal protein expression occurring with diabetes and their responsiveness to normalization of blood glucose through insulin therapy. These proteins, especially those not normalized by insulin therapy, may also be useful in preclinical drug development studies
Hospitalist-led medicine emergency department team: Associations with throughput, timeliness of patient care, and satisfaction
- Author
- Publication venue
- Publication date
- 01/01/2012
- Field of study
BACKGROUND: Admitted patients boarding in the emergency department (ED) leads to hospital diversion. Active bed management and care for boarded patients can improve throughput. We developed a hospital medicine ED (HMED) team to participate in active bed management, and to care for boarded patients, to decrease diversion and improve throughput
Heart Disease and Stroke Statistics—2012 Update
- Author
- Adán V
- Agency for Healthcare Research and Quality
- Ali T
- Ali T
- Anderson R
- Anderson RN
- Ayala C
- Barnes PM
- Barnes PM
- Barnes PM
- Barnes PM
- Barnes PM
- Blanck HM
- Borrell LN
- Budoff MJ
- Casper M
- Casper ML
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention (CDC).
- Centers for Medicare & Medicaid Services
- Centers for Medicare & Medicaid Services
- Committee on Quality of Health Care in America Institute of Medicine
- Crescioni M
- Davis C
- Drozda J
- Eaton DK
- Eaton DK
- Eaton DK
- Elixhauser A
- Elixhauser A
- Elixhauser A
- Elixhauser A
- Ervin RB
- Ervin RB
- Federal Interagency Forum on Aging-Related Statistics
- Food and Nutrition Board Institute of Medicine
- Ford ES
- Fowler V
- Fryar CD
- Fryar CD
- Fryar CD
- Gahche J
- Gold MR
- Goldenberg I
- Heron M
- International Society for the Study of Fatty Acids and Lipids
- Issa Z
- Kapen S
- Leibson CL
- McGruder H
- Moller J
- Murman DH
- National Association for Sport and Physical Education.
- National Center for Health Statistics
- National Center for Health Statistics
- National Center for Health Statistics Centers for Medicare and Medicaid Services
- Ogden CL
- Ostchega Y
- Quin E
- Rodriguez RD
- Ruilope LM
- Russo CA
- Russo CA
- Russo CA
- Sanchez RJ
- Schiller J
- Schiller J
- Schiller J
- Schiller J
- Schiller J
- Schiller J
- Schiller J
- Schober SE
- Shaw K
- Soni A
- Substance Abuse and Mental Health Services Administration.
- Thom T
- Thom TJ
- Tisdale J
- US Department of Health and Human Services.
- Wolbrette D
- World Health Organization
- World Health Organization/Food and Agriculture Organization of the United Nations
- Wright JD
- Xu J
- Xu J
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
Heart Disease and Stroke Statistics—2016 Update
- Author
- Adán V
- Almeida AL
- Alwan A.
- American Cancer Society
- American Heart Association
- Anderson RN
- Auerbach D
- Bach DS.
- Barnes PM
- Barnes PM
- Blanck HM
- Bloom DE
- Brett KM
- Caffrey C
- Carnethon MR
- Carroll MD
- Casper M
- Casper ML
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Medicare & Medicaid Services
- Chan PS
- Chiuve SE
- Cho I
- Committee on Quality of Health Care in America Institute of Medicine
- Courcoulas AP
- Crescioni M
- Davis C
- Department of Health and Human Services Centers for Disease Control and Prevention.
- Deshmukh-Taskar P
- Diercks DB
- Dunn WF
- D’Agostino RB
- Elixhauser A
- Ervin RB
- Ervin RB.
- Federal Interagency Forum on Aging-Related Statistics
- Filardo G
- Food and Nutrition Board Institute of Medicine
- Ford ES
- Fox CK
- Fryar CD
- Gahche J
- GISSI-Prevenzione Investigators (Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardico).
- Gold MR
- Goldenberg I
- Gu Q
- Guirguis-Blake J
- Hernesniemi JA
- Holman RC
- Homa DM
- Institute of Medicine (IOM)
- International Society for the Study of Fatty Acids and Lipids
- IOM (Institute of Medicine)
- Issa Z
- Jamal A
- Johnson NB
- Kann L
- Kann L
- Leonard CE
- Li C
- Marynak K
- Moller J
- Moran PS
- Mozaffarian RS
- Murman DH
- National Association for Sport and Physical Education.
- National Center for Health Statistics
- National Center for Health Statistics
- National Center for Health Statistics
- National Center for Health Statistics
- National Center for Health Statistics
- National Center for Health Statistics
- National Center for Health Statistics
- National Center for Health Statistics
- Nwankwo T
- Ogden CL
- Quilliam BJ
- Quin E
- Rodriguez RD
- Ruilope LM
- Russo C
- Schoenborn CA
- Shaw K
- Shaya GE
- Soni A.
- Sorice GP
- Stroke Unit Trialists Collaboration
- Substance Abuse and Mental Health Services Administration.
- Thom TJ
- Tisdale J
- Trimarchi S
- United States Renal Data System
- US Department of Agriculture and US Department of Health and Human Services
- US Department of Health and Human Services
- US Department of Health and Human Services
- US Department of Health and Human Services
- US Department of Health and Human Services
- US Department of Health and Human Services
- US Department of Health and Human Services Agency for Healthcare Research and Quality
- US Department of Health and Human Services Secretary’s Advisory Committee on Heritable Disorders in Newborns and Children
- van Wijk JP
- Wolbrette D
- World Health Organization
- World Health Organization
- World Health Organization Food and Agriculture Organization of the United Nations.
- Wright JD
- Yutaka Aoki
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
Heart Disease and Stroke Statistics—2015 Update
- Author
- Adán V
- Agency for Healthcare Research and Quality
- Ali T
- Alwan A
- Anderson RN
- Aoki Y
- Auerbach DI
- Bach DS
- Barnes PM
- Barnes PM
- Barnes PM
- Blanck HM
- Bloom DE
- Brett KM
- Buntin MB
- Caffrey C
- Carnethon MR
- Carroll MD
- Casper ML
- Casper ML
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC).
- Centers for Disease Control and Prevention National Center for Health Statistics
- Centers for Disease Control and Prevention National Center for Injury Prevention and Control
- Centers for Disease Control and Prevention.
- Centers for Medicare & Medicaid Services
- Chan PS
- Chiuve SE
- Committee on Quality of Health Care in America Institute of Medicine.
- Crescioni M
- Davis C
- Deshmukh-Taskar P
- Diercks DB
- Eaton DK
- Eaton DK
- Elixhauser A
- Ervin RB
- Ervin RB
- Fakhouri TH
- Federal Interagency Forum on Aging-Related Statistics
- Food and Nutrition Board Institute of Medicine.
- Ford ES
- Fowler V
- Fox CK
- Fryar CD
- Gage B
- Gahche J
- Goff DC
- Gold MR
- Goldenberg I
- Hernesniemi JA
- Holman RC
- International Society for the Study of Fatty Acids and Lipids.
- Issa Z
- Joint FAO/WHO Expert Consultation on Fats and Fatty Acids in Human Nutrition
- Kann L
- Kann L
- Kann L
- Kramer A
- Lackland DT
- Lane DA
- Leonard CE
- Li C
- Moller J
- Moran PS
- Murman DH
- Murphy SL
- National Association for Sport and Physical Education.
- National Center for Health Statistics
- National Center for Health Statistics
- National Center for Health Statistics.
- Nehler MR
- Nwankwo T
- Pfuntner A
- Quilliam BJ
- Quin E
- Rodriguez RD
- Ruilope LM
- Russo CA
- Sanchez RJ
- Shaw K
- Slipczuk L
- Soni A
- Sorice GP
- Stone NJ
- Stroke Unit Trialists’ Collaboration
- The Writing Group for the SEARCH for Diabetes in Youth Study Group.
- Thom TJ
- Tisdale J
- Trimarchi S
- US Department of Agriculture and US Department of Health and Human Services.
- US Department of Health and Human Services
- US Department of Health and Human Services
- US Department of Health and Human Services
- US Department of Health and Human Services
- US Department of Health and Human Services and US Department of Agriculture
- US Department of Health and Human Services Agency for Healthcare Research and Quality
- US Department of Health and Human Services Centers for Disease Control and Prevention, National Center for Health Statistics
- US Department of Health and Human Services.
- US Renal Data System
- US Renal Data System
- van Wijk JP
- Waitzfelder B
- Wolbrette D
- World Health Organization
- World Health Organization Food and Agriculture Organization of the United Nations.
- Wright JD
- Wright JD
- Yoon SS
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
Heart Disease and Stroke Statistics—2014 Update
- Author
- Adán V
- Agency for Healthcare Research and Quality
- Alan S. Go
- Ali T
- Ali T
- Amytis Towfighi
- Anderson RN
- Ariane Marelli
- Auerbach DI
- Bach DS
- Barnes PM
- Barnes PM
- Barnes PM
- Barnes PM
- Blackwell D
- Blackwell D
- Blackwell D
- Blackwell D
- Blackwell D
- Blackwell D
- Blackwell D
- Blanck HM
- Borrell LN
- Brett KM
- Brett M. Kissela
- Caffrey C
- Carnethon MR
- Caroline S. Fox
- Casper ML
- Casper ML
- Cathleen Gillespie
- Centers for Disease C Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention (CDC)
- Centers for Disease Control and Prevention National Center for Health Statistics
- Centers for Disease Control and Prevention National Center for Health Statistics
- Centers for Medicare & Medicaid Services
- Chan PS
- Chiuve SE
- Claudia S. Moy
- Committee on Quality of Health Care in America Institute of Medicine.
- Crescioni M
- Daniel T. Lackland
- Daniel Woo
- Dariush Mozaffarian
- Darren K. McGuire
- David B. Matchar
- David J. Magid
- Davis C
- Diercks DB
- Dilip K. Pandey
- Drozda J
- Earl S. Ford
- Eaton DK
- Eaton DK
- Eaton DK
- Elbers J
- Elixhauser A
- Elixhauser A
- Elixhauser A
- Elixhauser A
- Emelia J. Benjamin
- Emile R. Mohler
- Eraso LH
- Ervin RB
- Ervin RB
- Fakhouri TH
- Federal Interagency Forum on Aging-Related Statistics
- Food and Nutrition Board Institute of Medicine.
- Ford ES
- Fowler V
- Fryar CD
- Gold MR
- Goldenberg I
- Graham Nichol
- Gregory M. Marcus
- Heather J. Fullerton
- Hernesniemi JA
- Holman RC
- Holman RC
- Howlader N
- International Society for the Study of Fatty Acids and Lipids
- Issa Z
- Jarett D. Berry
- Joel Stein
- John A. Heit
- Jones AL
- Judith H. Lichtman
- Lackland DT
- Lackland DT
- Leibson CL
- Li C
- Lynda D. Lisabeth
- Mark D. Huffman
- Matthew J. Reeves
- Melanie B. Turner
- Michael E. Mussolino
- Michael J. Blaha
- Moller JH
- Murman DH
- Murphy SL
- Murphy SL
- Murphy SL
- Murphy SL
- Murphy SL
- Murphy SL
- Murphy SL
- Murphy SL
- Nathan D. Wong
- National Association for Sport and Physical Education
- National Center for Health Statistics
- National Center for Health Statistics
- National Center for Health Statistics
- National Center for Health Statistics
- National Cholesterol Education Program (NCEP) Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
- Nina P. Paynter
- Paul D. Sorlie
- Quilliam BJ
- Quin EM
- Rachel H. Mackey
- Robert W. Neumar
- Rodriguez RD
- Ruilope LM
- Russo CA
- Russo CA
- Russo CA
- Salim S. Virani
- Sanchez RJ
- Schiller J
- Schober S
- Shaw K
- Sheila Franco
- Shifan Dai
- Soni A
- Sorice GP
- Steven J. Kittner
- Susan M. Hailpern
- Suzanne E. Judd
- Tanya N. Turan
- Thom TJ
- Tisdale JE
- Trimarchi S
- United States Renal Data System
- US Burden of Disease Collaborators
- US Department of Agriculture and US Department of Health and Human Services
- US Department of Health and Human Services
- US Department of Health and Human Services
- US Department of Health and Human Services Agency for Healthcare Research and Quality.
- US Department of Health and Human Services National Center for Health Statistics.
- van Wijk JP
- Virginia J. Howard
- VĂ©ronique L. Roger
- Waitzfelder B
- Wang BC
- Wolbrette DL
- World Health Organization
- Wright JD
- Wright JD
- Yoon SS
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study