8 research outputs found
Osteopontin facilitates tumor metastasis by regulating epithelial–mesenchymal plasticity
No full textPreparation and characterization of β-sitosterol/β-cyclodextrin crystalline inclusion complexes
No full textEpigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinoma
No full textA tunable azine covalent organic framework platform for visible light-induced hydrogen generation
No full textBi-directional exosome-driven intercommunication between the hepatic niche and cancer cells
No full textIn vivo animal models for studying brain metastasis: value and limitations
No full textpeer reviewedBrain metastasis is associated with a particular poor prognosis. Novel insight into the brain metastatic process is therefore warranted. Several preclinical models of brain tumor metastasis have been developed during the last 60 years, and they have in part revealed some of the mechanisms underlying the metastatic process. This review discusses mechanisms of brain metastasis with a key focus of the development of animal model systems. This includes the use of rodent, syngeneic brain metastasis models (spontaneous, chemically induced and genetically engineered models) and human xenotransplantation models (ectopic inoculation and orthotopic models). Current information indicates that none of these fully reflect tumor development seen in patients with metastatic disease. The various model systems used, however, have provided important insight into specific mechanisms of the metastatic process related to the brain. By combining the knowledge obtained from animal models, new important information on the molecular mechanisms behind metastasis will be obtained, leading to the future development of new therapeutic strategies
